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Infants of Gestational Diabetic Mothers

Infants of Gestational Diabetic Mothers Abstract THE DIABETIC pregnancy and its effect on the fetus and newborn infant has been the subject of considerable interest.1-7 Diabetic mothers have a high incidence of abortions and stillbirths,4,5 and their infants have an increased incidence of neonatal problems such as idiopathic respiratory distress syndrome,6,7 hypoglycemia,8,9 and hyperbilirubinemia.10,11 An increased incidence of hypocalcemia,12,13 congenital malformations,14 and renal vein thrombosis15,16 has also been reported. In an attempt to determine which of these abnormalities are related to the abnormality in carbohydrate metabolism alone and which are related to the other complications of prolonged diabetes mellitus, the incidence of these problems in infants of gestational diabetic mothers17-19 has been studied. The purpose of this paper is to describe the clinical course and laboratory findings in infants of gestational diabetic mothers (IGDM) who have been cared for in the neonatal unit of the University of References 1. Dekaban, A., and Baird, R.: The Outcome of Pregnancy in Diabetic Women: I. Fetal Wastage, Mortality, and Morbidity in the Offspring of Diabetic and Normal Control Mothers , J Pediat 55:563-576 ( (Nov) ) 1959.Crossref 2. Miller, H.C.: The Effect of Diabetic and Prediabetic Pregnancies on the Fetus and Newborn Infant , J Pediat 29:455-461 ( (Oct) ) 1946.Crossref 3. Dolger, H.; Bookman, J.J.; and Nechemias, C.: The Management of Diabetes in Pregnancy , J Mount Sinai Hosp NY 30:479-490 ( (Nov) -Dec) 1963. 4. Gellis, S.S., and Hsia, D.Y.Y.: The Infant of the Diabetic Mother , Amer J Dis Child 97:1-41 ( (Jan) ) 1959. 5. Brandstrup, E.; Osler, M.; and Pedersen, J.: Perinatal Mortality in Diabetic Pregnancy , Acta Endocr 37:434-440 ( (July) ) 1961. 6. Driscoll, S.G.; Benirschke, K.; and Curtis, G.W.: Neonatal Death Among Infants of Diabetic Mothers , Amer J Dis Child 100:818-835 ( (Dec) ) 1960.Crossref 7. Hubbell, J.P., Jr., and Drorbaugh, J.E.: Infants of Diabetic Mothers: Neonatal Problems and Their Management , Diabetes 14:157-161 ( (March) ) 1965. 8. Pennoyer, M.M., and Hartmann, A.F., Sr.: Management of Infants Born of Diabetic Mothers , Postgrad Med 18:199-206 ( (Sept) ) 1955. 9. Cornblath, M., et al: Studies of Carbohydrate Metabolism in the Newborn Infant: IV. The Effect of Glucagon on the Capillary Blood Sugar in Infants of Diabetic Mothers , Pediatrics 28:592-601 ( (Oct) ) 1961. 10. Olsen, B.R.; Osler, M.; and Pedersen, J.: Neonatal Jaundice in Infants Born to Diabetic Mothers , Danish Med Bull 10:18-20 ( (Jan) ) 1963. 11. Zetterström, R.; Strindberg, B.; and Arnhold, R.G.: Hyperbilirubinemia and ABO Hemolytic Disease in Newborn Infants of Diabetic Mothers , Acta Paediat 47:238-250 ( (May) ) 1958.Crossref 12. Zetterström, R., and Arnhold, R.G.: Impaired Calcium-Phosphate Homeostasis in Newborn Infants of Diabetic Mothers , Acta Paediat 47:107-112 ( (March) ) 1958.Crossref 13. Gittleman, I.F., et al: Diabetes Mellitus or the Prediabetic State in the Mother and the Neonate , Amer J Dis Child 98:342-349 ( (Sept) ) 1959.Crossref 14. Pedersen, L.M.; Tygstrup, I.; and Pedersen, J.: Congenital Malformations in Newborn Infants of Diabetic Women: Correlation With Maternal Diabetic Vascular Complications , Lancet 1:1124-1130 ( (May 23) ) 1964.Crossref 15. Avery, M.E.; Oppenheimer, E.H.; and Gordon, H.H.: Renal-Vein Thrombosis in Newborn Infants of Diabetic Mothers , New Eng J Med 256:1134-1138 ( (June 13) ) 1957.Crossref 16. Takeuchi, A., and Benirschke, K.: Renal Venous Thrombosis of the Newborn and Its Relation to Maternal Diabetes , Biol Neonat 3:237-256, 1961.Crossref 17. O'Sullivan, J.B.; Gellis, S.S.; and Tenney, B.O.: Gestational Blood Glucose Levels in Normal and Potentially Diabetic Women Related to the Birth Weight of their Infants , Diabetes 15:466-470 ( (July) ) 1966. 18. O'Sullivan, J.B.: Oral Glucose Tolerance Tests; Diabetes Mellitus: Diagnosis and Treatment , New York: American Diabetes Association, Inc., 1967, vol 2, p 47. 19. O'Sullivan, J.B.: Gestational Diabetes: Unsuspected, Asymptomatic Diabetes in Pregnancy , New Eng J Med 264:1082-1085 ( (May) ) 1961.Crossref 20. White, P.: Symposium on Diabetes Mellitus: Pregnancy Complicating Diabetes , Amer J Med 7: 609-616 ( (Nov) ) 1949.Crossref 21. Marks, V.: An Improved Glucose Oxidase Method for Determining Blood, C.S.F. and Urine Glucose Levels , Clin Chim Acta 4:395-400 ( (Oct) ) 1959.Crossref 22. Swiatek, K.R., and Cornblath, M.: A Screening Method for Determining Glucose in Blood and Cerebrospinal Fluid, Amer J Dis Child, to be published. 23. Lubchenco, L.O., et al: Intrauterine Growth as Estimated From Live-Born Birth Weight Data at 24 to 42 Weeks of Gestation , Pediatrics 32: 793-800 ( (Nov) ) 1963. 24. Cornblath, M., and Schwartz, R.: Disorders of Carbohydrate Metabolism in Infancy, monograph in Major Problems in Clinical Pediatrics , vol 3, Philadelphia: W. B. Saunders Co., 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Infants of Gestational Diabetic Mothers

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References (30)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100030680010
Publisher site
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Abstract

Abstract THE DIABETIC pregnancy and its effect on the fetus and newborn infant has been the subject of considerable interest.1-7 Diabetic mothers have a high incidence of abortions and stillbirths,4,5 and their infants have an increased incidence of neonatal problems such as idiopathic respiratory distress syndrome,6,7 hypoglycemia,8,9 and hyperbilirubinemia.10,11 An increased incidence of hypocalcemia,12,13 congenital malformations,14 and renal vein thrombosis15,16 has also been reported. In an attempt to determine which of these abnormalities are related to the abnormality in carbohydrate metabolism alone and which are related to the other complications of prolonged diabetes mellitus, the incidence of these problems in infants of gestational diabetic mothers17-19 has been studied. The purpose of this paper is to describe the clinical course and laboratory findings in infants of gestational diabetic mothers (IGDM) who have been cared for in the neonatal unit of the University of References 1. Dekaban, A., and Baird, R.: The Outcome of Pregnancy in Diabetic Women: I. Fetal Wastage, Mortality, and Morbidity in the Offspring of Diabetic and Normal Control Mothers , J Pediat 55:563-576 ( (Nov) ) 1959.Crossref 2. Miller, H.C.: The Effect of Diabetic and Prediabetic Pregnancies on the Fetus and Newborn Infant , J Pediat 29:455-461 ( (Oct) ) 1946.Crossref 3. Dolger, H.; Bookman, J.J.; and Nechemias, C.: The Management of Diabetes in Pregnancy , J Mount Sinai Hosp NY 30:479-490 ( (Nov) -Dec) 1963. 4. Gellis, S.S., and Hsia, D.Y.Y.: The Infant of the Diabetic Mother , Amer J Dis Child 97:1-41 ( (Jan) ) 1959. 5. Brandstrup, E.; Osler, M.; and Pedersen, J.: Perinatal Mortality in Diabetic Pregnancy , Acta Endocr 37:434-440 ( (July) ) 1961. 6. Driscoll, S.G.; Benirschke, K.; and Curtis, G.W.: Neonatal Death Among Infants of Diabetic Mothers , Amer J Dis Child 100:818-835 ( (Dec) ) 1960.Crossref 7. Hubbell, J.P., Jr., and Drorbaugh, J.E.: Infants of Diabetic Mothers: Neonatal Problems and Their Management , Diabetes 14:157-161 ( (March) ) 1965. 8. Pennoyer, M.M., and Hartmann, A.F., Sr.: Management of Infants Born of Diabetic Mothers , Postgrad Med 18:199-206 ( (Sept) ) 1955. 9. Cornblath, M., et al: Studies of Carbohydrate Metabolism in the Newborn Infant: IV. The Effect of Glucagon on the Capillary Blood Sugar in Infants of Diabetic Mothers , Pediatrics 28:592-601 ( (Oct) ) 1961. 10. Olsen, B.R.; Osler, M.; and Pedersen, J.: Neonatal Jaundice in Infants Born to Diabetic Mothers , Danish Med Bull 10:18-20 ( (Jan) ) 1963. 11. Zetterström, R.; Strindberg, B.; and Arnhold, R.G.: Hyperbilirubinemia and ABO Hemolytic Disease in Newborn Infants of Diabetic Mothers , Acta Paediat 47:238-250 ( (May) ) 1958.Crossref 12. Zetterström, R., and Arnhold, R.G.: Impaired Calcium-Phosphate Homeostasis in Newborn Infants of Diabetic Mothers , Acta Paediat 47:107-112 ( (March) ) 1958.Crossref 13. Gittleman, I.F., et al: Diabetes Mellitus or the Prediabetic State in the Mother and the Neonate , Amer J Dis Child 98:342-349 ( (Sept) ) 1959.Crossref 14. Pedersen, L.M.; Tygstrup, I.; and Pedersen, J.: Congenital Malformations in Newborn Infants of Diabetic Women: Correlation With Maternal Diabetic Vascular Complications , Lancet 1:1124-1130 ( (May 23) ) 1964.Crossref 15. Avery, M.E.; Oppenheimer, E.H.; and Gordon, H.H.: Renal-Vein Thrombosis in Newborn Infants of Diabetic Mothers , New Eng J Med 256:1134-1138 ( (June 13) ) 1957.Crossref 16. Takeuchi, A., and Benirschke, K.: Renal Venous Thrombosis of the Newborn and Its Relation to Maternal Diabetes , Biol Neonat 3:237-256, 1961.Crossref 17. O'Sullivan, J.B.; Gellis, S.S.; and Tenney, B.O.: Gestational Blood Glucose Levels in Normal and Potentially Diabetic Women Related to the Birth Weight of their Infants , Diabetes 15:466-470 ( (July) ) 1966. 18. O'Sullivan, J.B.: Oral Glucose Tolerance Tests; Diabetes Mellitus: Diagnosis and Treatment , New York: American Diabetes Association, Inc., 1967, vol 2, p 47. 19. O'Sullivan, J.B.: Gestational Diabetes: Unsuspected, Asymptomatic Diabetes in Pregnancy , New Eng J Med 264:1082-1085 ( (May) ) 1961.Crossref 20. White, P.: Symposium on Diabetes Mellitus: Pregnancy Complicating Diabetes , Amer J Med 7: 609-616 ( (Nov) ) 1949.Crossref 21. Marks, V.: An Improved Glucose Oxidase Method for Determining Blood, C.S.F. and Urine Glucose Levels , Clin Chim Acta 4:395-400 ( (Oct) ) 1959.Crossref 22. Swiatek, K.R., and Cornblath, M.: A Screening Method for Determining Glucose in Blood and Cerebrospinal Fluid, Amer J Dis Child, to be published. 23. Lubchenco, L.O., et al: Intrauterine Growth as Estimated From Live-Born Birth Weight Data at 24 to 42 Weeks of Gestation , Pediatrics 32: 793-800 ( (Nov) ) 1963. 24. Cornblath, M., and Schwartz, R.: Disorders of Carbohydrate Metabolism in Infancy, monograph in Major Problems in Clinical Pediatrics , vol 3, Philadelphia: W. B. Saunders Co., 1966.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1969

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