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Carbonic Anhydrase Inhibitors in Chronic Infantile Hydrocephalus

Carbonic Anhydrase Inhibitors in Chronic Infantile Hydrocephalus Abstract The CHILD with slowly progressive hydrocephalus who is judged not to be suitable for neurosurgical treatment is still a common neuropediatric problem. The decision to withhold surgery may be based upon advanced hydrocephalus present at birth, the presence of associated somatic defects, or the lack of neurosurgical facilities. These children, in spite of advanced hydrocephalus, may demonstrate only minimal neurological abnormalities during the first years of life. The major disability of the infant is often only the mechanical problem of supporting the enlarged head. Ultimately a variety of disabilities become evident including visual defects, cerebellar ataxia, spastic diplegia, and mental retardation.1-3 An interesting special personality type characterized by excessive verbosity and inappropriate sociability (the cocktail party syndrome) has been considered as typical of hydrocephalic children during later development.4 The many difficulties associated with the surgical approaches available for the treatment of hydrocephalus have stimulated efforts for medical therapy References 1. Laurence, K.M., and Coates, S.: The Natural History of Hydrocephalus , Arch Dis Child 37: 345-362 ( (Aug) ) 1962.Crossref 2. Ingram, T.T.S., and Naughton, J.A.: Paediatric and Psychological Aspects of Cerebral Palsy Associated With Hydrocephalus , Develop Med Child Neurol 4:287-291 ( (June) ) 1962.Crossref 3. Hagberg, B., and Sjörgen, I.: The Chronic Brain Syndrome of Infantile Hydrocephalus , Amer J Dis Child 112:189-196 ( (Sept) ) 1966.Crossref 4. Hagberg, B.: The Sequelae of Spontaneously Arrested Infant Hydrocephalus , Develop Med Child Neurol 4:583-587 ( (Dec) ) 1962.Crossref 5. Tschirgi, R.D.; Frost, R.W.; and Taylor, J.L.: Inhibition of Cerebrospinal Fluid Formation by a Carbonic Anhydrase Inhibitor, 2; acetylamino-1, 3, 4; thiadiazole, 5; sulfonamide (Diamox) , Proc Soc Exp Biol Med 87:373-376 ( (Nov) ) 1954.Crossref 6. Pollay, M., and Davson, H.: The Passage of Certain Substances Out of the Cerebrospinal Fluid , Brain 86:137-150 ( (pt 1) ) 1963.Crossref 7. Oppelt, W.W.; Patlak, C.S.; and Rall, D.P.: Effect of Certain Drugs on Cerebrospinal Fluid Production in the Dog , Amer J Physiol 206:247-250 ( (Feb) ) 1964. 8. Elvridge, A.R.; Branch, C.L.; and Thompson, G.B.: Observation in a Case of Hydrocephalus Treated With Diamox , J Neurosurg 14:628-639 ( (June) ) 1957.Crossref 9. Birzis, L.; Carter, C.H.; and Maren, T.H.: Effect of Acetazolamide on CSF Pressure and Electrolytes in Hydrocephalus , Neurology 8:522-528 ( (July) ) 1958.Crossref 10. Maren, T.H., and Robinson, B.: The Pharmacology of Acetazolamide as Related to Cerebro spinal Fluid and the Treatment of Hydrocephalus , Johns Hopkins Med J 106:1-24 ( (Jan) ) 1960. 11. Huttenlocher, P.R.: Treatment of Hydrocephalus With Acetazolamide , J Pediat 66:1023-1030 ( (June) ) 1965.Crossref 12. Mealey, J., Jr., and Barker, D.T.: Failure of Oral Acetazolamide to Avert Hydrocephalus in Infants With Myelomeningocele , J Pediat 72:257-259 ( (Feb) ) 1968.Crossref 13. Bering, E.A., Jr., and Sato, O.: Hydrocephalus: Changes in Formation and Absorption of Cerebrospinal Fluid Within Cerebral Ventricles , J Neurosurg 20:1050-1063 ( (Dec) ) 1963.Crossref 14. Gray, W.D., et al: Carbonic Anhydrase Inhibition: VII. Carbonic Anhydrase Inhibition and Anticonvulsant Effect , J Pharmacol Exp Ther 121: 160-170 ( (Oct) ) 1957. 15. Travis, D.M., et al: Selective Renal Carbonic Anhydrase Inhibition Without Respiratory Effect: Pharmacology of 2-benzenesulfonamide-1, 3, 4, -thiadiazole-5-sulfonamide (CL 11, 366) , J Pharmacol Exp Ther 143:383-394 ( (March) ) 1964. 16. Schonenberg, H.: Der Liquor Cerebrospinalis im Kindesalter , Stuttgart, Germany, Georg Thieme, 1960, p 27. 17. Stevenson, L.; Christensen, B.E.; and Wortis, S.B.: Some Experiments on Intracranial Pressure in Man During Sleep and Under Certain Other Conditions , Assoc Res Nerv Ment Dis 8:130-159, 1929. 18. Hayden, P.W.; Foltz, E.L.; and Shurtleff, D.B.: Effect of an Oral Osmotic Agent on Ventricular Fluid Pressure of Hydrocephalic Children , Pediatrics 41:955-967 ( (May) ) 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Carbonic Anhydrase Inhibitors in Chronic Infantile Hydrocephalus

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100030623002
Publisher site
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Abstract

Abstract The CHILD with slowly progressive hydrocephalus who is judged not to be suitable for neurosurgical treatment is still a common neuropediatric problem. The decision to withhold surgery may be based upon advanced hydrocephalus present at birth, the presence of associated somatic defects, or the lack of neurosurgical facilities. These children, in spite of advanced hydrocephalus, may demonstrate only minimal neurological abnormalities during the first years of life. The major disability of the infant is often only the mechanical problem of supporting the enlarged head. Ultimately a variety of disabilities become evident including visual defects, cerebellar ataxia, spastic diplegia, and mental retardation.1-3 An interesting special personality type characterized by excessive verbosity and inappropriate sociability (the cocktail party syndrome) has been considered as typical of hydrocephalic children during later development.4 The many difficulties associated with the surgical approaches available for the treatment of hydrocephalus have stimulated efforts for medical therapy References 1. Laurence, K.M., and Coates, S.: The Natural History of Hydrocephalus , Arch Dis Child 37: 345-362 ( (Aug) ) 1962.Crossref 2. Ingram, T.T.S., and Naughton, J.A.: Paediatric and Psychological Aspects of Cerebral Palsy Associated With Hydrocephalus , Develop Med Child Neurol 4:287-291 ( (June) ) 1962.Crossref 3. Hagberg, B., and Sjörgen, I.: The Chronic Brain Syndrome of Infantile Hydrocephalus , Amer J Dis Child 112:189-196 ( (Sept) ) 1966.Crossref 4. Hagberg, B.: The Sequelae of Spontaneously Arrested Infant Hydrocephalus , Develop Med Child Neurol 4:583-587 ( (Dec) ) 1962.Crossref 5. Tschirgi, R.D.; Frost, R.W.; and Taylor, J.L.: Inhibition of Cerebrospinal Fluid Formation by a Carbonic Anhydrase Inhibitor, 2; acetylamino-1, 3, 4; thiadiazole, 5; sulfonamide (Diamox) , Proc Soc Exp Biol Med 87:373-376 ( (Nov) ) 1954.Crossref 6. Pollay, M., and Davson, H.: The Passage of Certain Substances Out of the Cerebrospinal Fluid , Brain 86:137-150 ( (pt 1) ) 1963.Crossref 7. Oppelt, W.W.; Patlak, C.S.; and Rall, D.P.: Effect of Certain Drugs on Cerebrospinal Fluid Production in the Dog , Amer J Physiol 206:247-250 ( (Feb) ) 1964. 8. Elvridge, A.R.; Branch, C.L.; and Thompson, G.B.: Observation in a Case of Hydrocephalus Treated With Diamox , J Neurosurg 14:628-639 ( (June) ) 1957.Crossref 9. Birzis, L.; Carter, C.H.; and Maren, T.H.: Effect of Acetazolamide on CSF Pressure and Electrolytes in Hydrocephalus , Neurology 8:522-528 ( (July) ) 1958.Crossref 10. Maren, T.H., and Robinson, B.: The Pharmacology of Acetazolamide as Related to Cerebro spinal Fluid and the Treatment of Hydrocephalus , Johns Hopkins Med J 106:1-24 ( (Jan) ) 1960. 11. Huttenlocher, P.R.: Treatment of Hydrocephalus With Acetazolamide , J Pediat 66:1023-1030 ( (June) ) 1965.Crossref 12. Mealey, J., Jr., and Barker, D.T.: Failure of Oral Acetazolamide to Avert Hydrocephalus in Infants With Myelomeningocele , J Pediat 72:257-259 ( (Feb) ) 1968.Crossref 13. Bering, E.A., Jr., and Sato, O.: Hydrocephalus: Changes in Formation and Absorption of Cerebrospinal Fluid Within Cerebral Ventricles , J Neurosurg 20:1050-1063 ( (Dec) ) 1963.Crossref 14. Gray, W.D., et al: Carbonic Anhydrase Inhibition: VII. Carbonic Anhydrase Inhibition and Anticonvulsant Effect , J Pharmacol Exp Ther 121: 160-170 ( (Oct) ) 1957. 15. Travis, D.M., et al: Selective Renal Carbonic Anhydrase Inhibition Without Respiratory Effect: Pharmacology of 2-benzenesulfonamide-1, 3, 4, -thiadiazole-5-sulfonamide (CL 11, 366) , J Pharmacol Exp Ther 143:383-394 ( (March) ) 1964. 16. Schonenberg, H.: Der Liquor Cerebrospinalis im Kindesalter , Stuttgart, Germany, Georg Thieme, 1960, p 27. 17. Stevenson, L.; Christensen, B.E.; and Wortis, S.B.: Some Experiments on Intracranial Pressure in Man During Sleep and Under Certain Other Conditions , Assoc Res Nerv Ment Dis 8:130-159, 1929. 18. Hayden, P.W.; Foltz, E.L.; and Shurtleff, D.B.: Effect of an Oral Osmotic Agent on Ventricular Fluid Pressure of Hydrocephalic Children , Pediatrics 41:955-967 ( (May) ) 1968.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1969

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