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N. Danbolt (1942)
Akrodermatitis EnteropathicaActa Dermatovener, 23
A.M. Margileth (1963)
Acrodermatitis Enteropathica: Case Report and Review of LiteratureAmer J Dis Child, 105
L. Wirsching (1962)
Eye Symptoms in Acrodermatitis EnteropathicanActa Ophthal, 40
J.E. Etheridge (1966)
Treating Acrodermatitis EnteropathicaLancet, 1
Abstract Denouement and Discussion Acrodermatitis Enteropathica (Danbolt-Closs Syndrome) Manifestations Acrodermatitis enteropathica usually manifests itself in infancy, shortly after the child has been weaned or has been started on supplementary formula. It is characterized by a symmetrical, erythematous, and vesiculopustular dermatitis localized to the extremities and areas around the body orifices, diarrhea, and alopecia. Additional manifestations include blepharitis, conjunctivitis, corneal opacities, photophobia, stomatitis, glossitis, hoarsness, paronychiae with dystrophy of the nails, failure to thrive, apathy, irritability, and emotional disturbances.Without treatment the disease may be progressive. Short remissions are followed by relapses which are increasingly severe and end fatally. Spontaneous healing has been reported in relation to onset of puberty. Genetics Acrodermatitis enteropathica appears to be inherited as an autosomal recessive trait. Treatment Derivatives of halogen-substituted 8-hydroxy-quinolines (Diodoquin, Entero-Vioform, or Sterosan) are the drugs of choice. Initially a high dosage is often needed for effective treatment, but it is important to determine References 1. Danbolt, N., and Closs, K.: Akrodermatitis Enteropathica , Acta Dermatovener 23:127-169, 1942. 2. Wirsching, L.: Eye Symptoms in Acrodermatitis Enteropathican , Acta Ophthal 40: 567-574, 1962.Crossref 3. Margileth, A.M.: Acrodermatitis Enteropathica: Case Report and Review of Literature , Amer J Dis Child 105:285-291 ( (March) ) 1963.Crossref 4. Etheridge, J.E., and Stewart, G.E.: Treating Acrodermatitis Enteropathica , Lancet 1: 261 ( (Jan 29) ) 1966.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Feb 1, 1969
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