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Adrenocortical Carcinoma With Virilism in an Infant Under 1 Year of Age

Adrenocortical Carcinoma With Virilism in an Infant Under 1 Year of Age Abstract ADRENAL HORMONE producing neoplasms in infancy are rare; however, the limited literature reflects a poor, but by no means hopeless, prognosis.1,2 Only one case of virilism due to adrenocortical carcinoma, with surgical cure, has been reported in an infant under 1 year of age.3 This paper describes a virilized infant with adrenal cortical carcinoma who is presumptively cured after surgical excision of the tumor. Report of a Case A 10½-month-old white female was admitted to William Beaumont General Hospital on April 14, 1964, because of pubic hair growth of one month's duration. She was born at this hospital after an uncomplicated pregnancy. The birth weight was 2.9 kg (6 lb 4 oz) and she was judged to be a normal infant. Routine examinations at 6 weeks and 3 months revealed normal growth and development. At 9½ months of age, growth of pubic hair began, and medical advice was References 1. Sobel, E.H., et al: Functioning Adrenal Tumors in Childhood , Amer J Dis Child 86:733, 1953. 2. Goldstein, H.M.: Cushing's Syndrome Due to Tumor of the Adrenal Cortex: Report of a Case of an 11-Month-Old Infant With Apparent Operative Cure , Amer J Dis Child 78:260, 1949.Crossref 3. Goldstein, A.E.; Rubin, S.E.; and Askin, J.A.: Carcinoma of Adrenal Cortex With Adrenogenital Syndrome in Children: Complete Review of the Literature and Report of a Case With Recovery in a Child Eight Months of Age , Amer J Dis Child 72:564, 1946.Crossref 4. Cavell, B.: Primary Aldosteronism Due to an Adrenal Adenoma in a Three Year Old Child , Acta Med Scand 174:1, 1963. 5. Crane, M.G., and Harris, J.J.: Desoxycorticosterone Secretion Rates in Hyperadrenocorticism , J. Clin Endocr 26:135, 1966. 6. Bongiovanni, A.M., and Root, A.W.: The Adrenogenital Syndrome , New Eng J Med 268:1283, 1963.Crossref 7. Wilkins, L.: The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence , ed 3, Springfield, Ill: Charles C Thomas, Publishers, 1965. 8. Dahl, A.J., and Bastrup-Madsen, P.: Adrenogenital syndrom forarsaget af binyrebarkkarcinom hos et spaedbarn , Ugeskr Laeg 125:326, 1963. 9. Hinman, F., Jr.: Adrenal Disorders of Childhood in Symposium of Pediatric Urology , Pediat Clin N Amer 2:889, 1955. 10. Sherman, F.E.; Bass, L.W.; and Fetterman, G.H.: Congenital Metastasizing Adrenal Cortical Carcinoma Associated With Cytomegaly of the Fetal Adrenal Cortex , Amer J Clin Path 30:439, 1958. 11. Gelli, G., and Della Santa, L.: Cushing's Syndrome in Early Infancy , Minerva Pediat 11:1389, 1959. 12. Davies, D.M.: Cushing's Syndrome in a Child 2½ Years , Proc Royal Soc Med 46:307, 1953. 13. Puzynsky, D.L., and Biehusen, F.C.: Adrenocortical Adenoma With Cushing's Syndrome and Virilism in a 5-Year-Old Child , J Pediat 60:836, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Adrenocortical Carcinoma With Virilism in an Infant Under 1 Year of Age

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1967.02090210144019
Publisher site
See Article on Publisher Site

Abstract

Abstract ADRENAL HORMONE producing neoplasms in infancy are rare; however, the limited literature reflects a poor, but by no means hopeless, prognosis.1,2 Only one case of virilism due to adrenocortical carcinoma, with surgical cure, has been reported in an infant under 1 year of age.3 This paper describes a virilized infant with adrenal cortical carcinoma who is presumptively cured after surgical excision of the tumor. Report of a Case A 10½-month-old white female was admitted to William Beaumont General Hospital on April 14, 1964, because of pubic hair growth of one month's duration. She was born at this hospital after an uncomplicated pregnancy. The birth weight was 2.9 kg (6 lb 4 oz) and she was judged to be a normal infant. Routine examinations at 6 weeks and 3 months revealed normal growth and development. At 9½ months of age, growth of pubic hair began, and medical advice was References 1. Sobel, E.H., et al: Functioning Adrenal Tumors in Childhood , Amer J Dis Child 86:733, 1953. 2. Goldstein, H.M.: Cushing's Syndrome Due to Tumor of the Adrenal Cortex: Report of a Case of an 11-Month-Old Infant With Apparent Operative Cure , Amer J Dis Child 78:260, 1949.Crossref 3. Goldstein, A.E.; Rubin, S.E.; and Askin, J.A.: Carcinoma of Adrenal Cortex With Adrenogenital Syndrome in Children: Complete Review of the Literature and Report of a Case With Recovery in a Child Eight Months of Age , Amer J Dis Child 72:564, 1946.Crossref 4. Cavell, B.: Primary Aldosteronism Due to an Adrenal Adenoma in a Three Year Old Child , Acta Med Scand 174:1, 1963. 5. Crane, M.G., and Harris, J.J.: Desoxycorticosterone Secretion Rates in Hyperadrenocorticism , J. Clin Endocr 26:135, 1966. 6. Bongiovanni, A.M., and Root, A.W.: The Adrenogenital Syndrome , New Eng J Med 268:1283, 1963.Crossref 7. Wilkins, L.: The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence , ed 3, Springfield, Ill: Charles C Thomas, Publishers, 1965. 8. Dahl, A.J., and Bastrup-Madsen, P.: Adrenogenital syndrom forarsaget af binyrebarkkarcinom hos et spaedbarn , Ugeskr Laeg 125:326, 1963. 9. Hinman, F., Jr.: Adrenal Disorders of Childhood in Symposium of Pediatric Urology , Pediat Clin N Amer 2:889, 1955. 10. Sherman, F.E.; Bass, L.W.; and Fetterman, G.H.: Congenital Metastasizing Adrenal Cortical Carcinoma Associated With Cytomegaly of the Fetal Adrenal Cortex , Amer J Clin Path 30:439, 1958. 11. Gelli, G., and Della Santa, L.: Cushing's Syndrome in Early Infancy , Minerva Pediat 11:1389, 1959. 12. Davies, D.M.: Cushing's Syndrome in a Child 2½ Years , Proc Royal Soc Med 46:307, 1953. 13. Puzynsky, D.L., and Biehusen, F.C.: Adrenocortical Adenoma With Cushing's Syndrome and Virilism in a 5-Year-Old Child , J Pediat 60:836, 1962.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1967

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