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Capillary Microscopy: Abnormalities in Cystic Fibrosis, Congenital Heart Disease, and Mongolism

Capillary Microscopy: Abnormalities in Cystic Fibrosis, Congenital Heart Disease, and Mongolism Abstract ATTENTION has recently been directed toward the anatomy and physiology of the microvasculature. In humans, the direct observation of capillaries has been limited to but a few areas, namely, the conjunctivae, ocular fundi, and the skin. Because of its unique anatomic structure, the nailbed affords a readily accessible area for microscopic visualization of the capillaries. Capillary microscopy was originally described in 1912 by Lombard1 and subsequently reviewed in the pediatric literature by Leader.2 Recently Kontras and Bodenbender3 described abnormal capillary morphology in congenital heart disease and noted its association with blood coagulation defects. Similar studies have also been reported in mongoloid children.2 The present investigation was undertaken to extend these observations and to study the morphology of the nailbed capillaries in children with cystic fibrosis. Materials and Methods One hundred and ten children and adolescents were examined. Twenty (age 4 to 16 years) were normal, 23 References 1. Lombard, W.P.: The Blood Pressure in the Arterioles, Capillaries, and Small Veins of the Human Skin , Amer J Physiol 29:335, 1912. 2. Leader, S.D.: Capillary Microscopy in Children , Amer J Dis Child 44:403, 1932. 3. Kontras, S.B., and Bodenbender, J.G.: Abnormal Capillary Morphology in Congenital Heart Disease , Pediat 37:316, 1966. 4. Doust, J.W.: The Capillary System in Patients With Psychiatric Disorders: The Ontogenetic Structural Determination of the Nailfold Capillaries as Observed by Photomicroscopy , J Nerv Ment Dis 121:516, 1955.Crossref 5. Shwachman, H., and Kulczycki, L.L.: Longterm Study of One-Hundred Five Patients With Cystic Fibrosis: Studies Made Over a Five to Fourteen-Year Period , Amer J Dis Child 96:6, 1958.Crossref 6. Walls, E.W., and Buchanan, T.G.: Observations on the Capillary Blood Vessels of the Human Nailfold , J Anat 90:329, 1956. 7. Powdermaker, F.: Capillary Forms in Relation to Certain Problems in Development , Arch Neurol Psychiat 22:1207, 1929.Crossref 8. Bashour, F.A.: Clubbing of the Digits: Physiological Considerations , J Lab Clin Med 58:613, 1961. 9. DePasquale, N.P., and Burch, G.E.: Digital Vascular Responses to Intra-arterial Injections of Bradykinin, Kallidin, and Eledoisin in Man , Circulation 34:211, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Capillary Microscopy: Abnormalities in Cystic Fibrosis, Congenital Heart Disease, and Mongolism

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1967.02090190085006
Publisher site
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Abstract

Abstract ATTENTION has recently been directed toward the anatomy and physiology of the microvasculature. In humans, the direct observation of capillaries has been limited to but a few areas, namely, the conjunctivae, ocular fundi, and the skin. Because of its unique anatomic structure, the nailbed affords a readily accessible area for microscopic visualization of the capillaries. Capillary microscopy was originally described in 1912 by Lombard1 and subsequently reviewed in the pediatric literature by Leader.2 Recently Kontras and Bodenbender3 described abnormal capillary morphology in congenital heart disease and noted its association with blood coagulation defects. Similar studies have also been reported in mongoloid children.2 The present investigation was undertaken to extend these observations and to study the morphology of the nailbed capillaries in children with cystic fibrosis. Materials and Methods One hundred and ten children and adolescents were examined. Twenty (age 4 to 16 years) were normal, 23 References 1. Lombard, W.P.: The Blood Pressure in the Arterioles, Capillaries, and Small Veins of the Human Skin , Amer J Physiol 29:335, 1912. 2. Leader, S.D.: Capillary Microscopy in Children , Amer J Dis Child 44:403, 1932. 3. Kontras, S.B., and Bodenbender, J.G.: Abnormal Capillary Morphology in Congenital Heart Disease , Pediat 37:316, 1966. 4. Doust, J.W.: The Capillary System in Patients With Psychiatric Disorders: The Ontogenetic Structural Determination of the Nailfold Capillaries as Observed by Photomicroscopy , J Nerv Ment Dis 121:516, 1955.Crossref 5. Shwachman, H., and Kulczycki, L.L.: Longterm Study of One-Hundred Five Patients With Cystic Fibrosis: Studies Made Over a Five to Fourteen-Year Period , Amer J Dis Child 96:6, 1958.Crossref 6. Walls, E.W., and Buchanan, T.G.: Observations on the Capillary Blood Vessels of the Human Nailfold , J Anat 90:329, 1956. 7. Powdermaker, F.: Capillary Forms in Relation to Certain Problems in Development , Arch Neurol Psychiat 22:1207, 1929.Crossref 8. Bashour, F.A.: Clubbing of the Digits: Physiological Considerations , J Lab Clin Med 58:613, 1961. 9. DePasquale, N.P., and Burch, G.E.: Digital Vascular Responses to Intra-arterial Injections of Bradykinin, Kallidin, and Eledoisin in Man , Circulation 34:211, 1966.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Apr 1, 1967

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