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R. Quan-Ma, W. Wells (1965)
The distribution of galactitol in tissues of rats fed galactose.Biochemical and biophysical research communications, 20 4
J. Folch, M. Lees, G. Stanley (1957)
A simple method for the isolation and purification of total lipides from animal tissues.The Journal of biological chemistry, 226 1
W. Wells, T. Chin, B. Weber (1964)
QUANTITATIVE ANALYSIS OF SERUM AND URINE SUGARS BY GAS CHROMATOGRAPHY.Clinica chimica acta; international journal of clinical chemistry, 10
W. Wells, T. Pittman, H. Wells (1965)
Quantitative analysis of myoinositol in rat tissue by gas-liquid chromatographyAnalytical Biochemistry, 10
T. Egan, W. Wells (1966)
Alternate metabolic pathway in galactosemia. Observations in patient with galactosemia.American journal of diseases of children, 111 4
W. Wells, T. Pittman, H. Wells, T. Egan (1965)
THE ISOLATION AND IDENTIFICATION OF GALACTITOL FROM THE BRAINS OF GALACTOSEMIA PATIENTS.The Journal of biological chemistry, 240
W. Wells, T. Pittman, T. Egan (1964)
THE ISOLATION AND IDENTIFICATION OF GALACTITOL FROM THE URINE OF PATIENTS WITH GALACTOSEMIA.The Journal of biological chemistry, 239
Abstract GALACTITOL has recently been isolated from the urine1 and brain2 of galactosemia patients. Subsequently the conversion of orally administered galactose- 1-C14 into galactitol-1-C14 by a 17-year-old male galactosemia patient was demonstrated.3 In order to account for the relatively slow excretion of administered radioactivity as galactitol-C14 it was suggested that there had either been deposition of galactitol in tissues of the body, or that the administered galactose-C14 had been incorporated into galactose-containing compounds. This hypothesis was further supported by the finding of galactitol in a variety of tissues in a rat fed large amounts of galactose.4 We now wish to report the galactitol, glucose, free, and phosphatide-bound myo-inositol content of body tissue from 17 areas of an infant presumed to be galactosemic. Material and Methods The patient studied was a 23-day-old male infant who was jaundiced on the third day of life. References 1. Wells, W.W.; Pittman, T.A.; and Egan, T.J.: The Isolation and Identification of Galactitol From the Urine of Patients With Galactosemia , J Biol Chem 239:3192, 1964. 2. Wells, W.W., et al: The Isolation and Identification of Galactitol From the Brains of Galactosemia Patients , J Biol Chem 240:1002, 1965. 3. Egan, T.J., and Wells, W.W.: Alternate Metabolic Pathway in Galactosemia: Observations in a Patient With Galactosemia , Amer J Dis Child 111: 400, 1966.Crossref 4. Quan-Ma, R., and Wells, W.W.: The Distribution of Galactitol in Tissues of Rats Fed Galactose , Biochem Biophys Res Commun 20:486, 1965.Crossref 5. Folch, J.; Lees, M.; and Sloane-Stanley, G.H.: A Simple Method for the Isolation and Purification of Total Lipides From Animal Tissues , J Biol Chem 226:497, 1957. 6. Wells, W.W.; Chin, T.; and Weber, B.: Quantitative Analysis of Serum and Urine Sugars by Gas Chromatography , Clin Chim Acta 10:352, 1964.Crossref 7. Wells, W.W.; Pittman, T.A.; and Wells, H.J.: Quantitative Analysis of Myoinositol in Rat Tissue by Gas-Liquid Chromatography , Anal Biochem 10: 450, 1965.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Nov 1, 1966
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