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W. Zinkham, W. Zinkham (1962)
Metabolism of glucose by erythrocytes from patients with congenital hemolytic disordersThe Journal of Pediatrics, 60
R. Gross, R. Hurwitz, P. Marks (1958)
An hereditary enzymatic defect in erythrocyte metabolism: glucose-6-phosphage dehydrogenase deficiency.The Journal of clinical investigation, 37 8
P. Marks, R. Gross (1959)
Erythrocyte glucose-6-phosphate dehydrogenase deficiency: evidence of differences between Negroes and Caucasians with respect to this genetically determined trait.The Journal of clinical investigation, 38
A.R. Tarlov (1962)
Primaquine Sensitivity: Glucose-6-Phosphate Dehydrogenase DeficiencyArch Intern Med, 109
D. Mohler, W. Williams (1961)
The effect of phenylhydrazine on the adenosine triphosphate content of normal and glucose-6-phosphate dehydrogenase-deficient human blood.The Journal of clinical investigation, 40
Kirkman Hn, Hendrickson Em (1963)
Sex-linked electrophoretic difference in glucose-6-phosphate dehydrogenase.American Journal of Human Genetics, 15
J. Jandl (1963)
The Heinz body hemolytic anemias.Annals of internal medicine, 58
E. Beutler (1957)
The glutathione instability of drug-sensitive red cells; a new method for the in vitro detection of drug sensitivity.The Journal of laboratory and clinical medicine, 49 1
J. Naylor, I. Rosenthal, A. Grossman, I. Schulman, D. Hsia (1960)
Activity of glucose-6-phosphate dehydrogenase in erythrocyes of patients with various abnormal hemoglobins.Pediatrics, 26
H.N.: " Kirkman (1961)
Molecular Genetics and Human Disease
H.N. Kirkman , F. Schettini, B.M. and Pickard (1964)
Mediterranean Variant of Glucose-6-Phosphate DehydrogenaseJ Lab Clin Med, 63
G. Brewer, A. Tarlov, A. Alving (1962)
The Methemoglobin Reduction Test for Primaquine-Type Sensitivity of Erythrocytes: A Simplified Procedure for Detecting a Specific Hypersusceptibility to Drug HemolysisJAMA, 180
E.: " Beutler (1960)
The Metabolic Basis of Inherited Diseases
Kellermeyer Rw, A. Tarlov, G. Brewer, Paul Carson, A. Alving (1962)
Hemolytic effect of therapeutic drugs. Clinical considerations of the primaquine-type hemolysis.JAMA, 180
Abstract SEVERAL HEMOLYTIC anemias are characterized by deficiency of the enzyme glucose-6-phosphate dehydrogenase (G-6-PD) in the erythrocyte. Among these are the primaquinesensitive anemias found in Negroes, a group of nonspherocytic anemias found in Caucasians, and the anemia secondary to the ingestion of fava beans in sensitive individuals. Although they share a similar defect in erythrocyte metabolism, these anemias are otherwise different.1-5 When primaquine-sensitive individuals have a severe infection or are exposed to various chemicals and drugs, a hemolytic process may ensue. The mechanism of erythrocyte destruction has not been completely established but a demonstrable and major factor is the deficiency of G-6-PD in the erythrocyte which becomes critical as the cell ages.5 The purpose of this report is to emphasize the variability of clinical manifestations and the diagnostic problems encountered in 14 Negro children and their families with primaquinesensitive anemia. Some clinical patterns of expression are delineated under the References 1. Beutler, E.: " Drug-Induced Hemolytic Anemia (Primaquine Sensitivity) ," in Stanbury, J.B.; Wyngaarden, J.B.; and Fredrickson, D.S. (eds.): The Metabolic Basis of Inherited Diseases , New York: McGraw-Hill Book Co., Inc., 1960, chap 32, pp 1031-1067. 2. Kirkman, H.N.: " Primaquine Sensitivity ," in Gardner, L.E. (ed.): Molecular Genetics and Human Disease , Springfield, Ill: Charles C Thomas, Publisher, 1961, chap 7, pp 106-133. 3. Marks, P.A., and Gross, R.T.: Erythrocyte Glucose-6-Phosphate Dehydrogenase Deficiency: Evidence of Differences Between Negroes and Caucasians With Respect to This Genetically Determined Trait , J Clin Invest 38:2253-2262 ( (December) ) 1959.Crossref 4. Zinkham, W.H.: Metabolism of Glucose by Erythrocytes From Patients With Congenital Hemolytic Disorders , J Pediat 60:614-622 ( (April) ) 1962.Crossref 5. Tarlov, A.R., et al: Primaquine Sensitivity: Glucose-6-Phosphate Dehydrogenase Deficiency; An Inborn Error of Metabolism of Medical and Biological Significance , Arch Intern Med 109:209-234 ( (February) ) 1962.Crossref 6. Brewer, G.J.; Tarlov, A.R.; and Alving, A.S.: The Methemoglobin Reduction Test for Primaquine-Type Sensitivity of Erythrocytes: A Simplified Procedure for Detecting a Specific Hypersusceptibility to Drug Hemolysis , JAMA 180:386-388 ( (May 5) ) 1962.Crossref 7. Beutler, E.: The Glutathione Instability of Drug-Sensitive Red Cells: A New Method for the in Vitro Detection of Drug Sensitivity , J Lab Clin Med 49:84-95 ( (January) ) 1957. 8. Mohler, D.N., and Williams, W.J.: The Effect of Pheylhydrazine on the Adenosine Triphosphate Content of Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Human Blood , J Clin Invest 40:1735-1742 ( (September) ) 1961.Crossref 9. Naylor, J., et al: Activity of Glucose-6-Phosphate Dehydrogenase in Erythrocytes of Patients With Various Abnormal Hemoglobins , Pediatrics 26:285-292 ( (August) ) 1960. 10. Kirkman, H.N.; Schettini, F.; and Pickard, B.M.: Mediterranean Variant of Glucose-6-Phosphate Dehydrogenase , J Lab Clin Med 63:726-735 ( (May) ) 1964. 11. Kirkman, H.N., and Hendrickson, E.M.: Sex-Linked Electrophoretic Difference in Glucose-6-Phosphate Dehydrogenase , Amer J Hum Genet 15:241-258 ( (September) ) 1963. 12. Gross, R.T.; Hurwitz, R.E.; and Marks, P.A.: An Hereditary Enzymatic Defect in Erythrocyte Metabolism: Glucose-6-Phosphate Dehydrogenase Deficiency , J Clin Invest 37: 1176-1184 ( (August) ) 1958.Crossref 13. Jandl, J.H.: The Heinz Body Hemolytic Anemias , Ann Intern Med 58:702-709 ( (April) ) 1963.Crossref 14. Kellermeyer, R.W., et al: Hemolytic Effect of Therapeutic Drugs: Clinical Considerations of the Primaquine-Type Hemolysis , JAMA 180:388-394 ( (May 5) ) 1962.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Aug 1, 1965
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