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Salt Taste Thresholds and Cystic Fibrosis

Salt Taste Thresholds and Cystic Fibrosis Abstract A great deal of interest has been shown in the sodium chloride taste threshold in humans and its significance, particularly in regard to various disease states, such as cystic fibrosis of the pancreas,6 adrenal cortical insufficiency,7 etc. Many methods have been employed for determining the human salt taste threshold, but the lack of a uniform or standardized approach has resulted in considerable confusion in interpreting the results of such studies. Henkin6,7 reported a significant difference in the salt taste thresholds of patients with cystic fibrosis of the pancreas when compared to those of normals and has suggested that this might be the basis of a diagnostic test for cystic fibrosis of the pancreas. Since the potential value of such a diagnostic procedure was considered to be of great importance, it was deemed advisable to pursue these studies further. For such purposes, it was decided to use as References 1. Burgen, A. S. V., and Emmelin, M. G.: Physiology of Salivary Glands , Baltimore: The Williams & Wilkins Company, 1961, pp 152, 153. 2. Chauncey, H. H., et al: Composition of Human Saliva: Parotid Gland Secretory Rate and Electrolyte Concentration in Children With Cystic Fibrosis , Arch Oral Biol 7:707, 1963.Crossref 3. Fallis, N.; Lasagna, L.; and Tetreault, L.: Gustatory Threshold in Patients With Hypertension , Nature (London) 196:74, 1962.Crossref 4. Harris, H., and Kalmus, H.: Measurement of Taste Sensitivity to Phenylthiourea (PTC) , Ann Eugen (London) 16:226, 1951.Crossref 5. Harris, H.: Introduction to Human Biochemical Genetics , New York: Cambridge Univ. Press, 1953, p 70. 6. Henkin, R. I.: Increased Sensitivity of Taste and Smell in Cystic Fibrosis , Science 138:1107, 1962.Crossref 7. Henkin, R. I.; Gill, J. R.; and Bartter, F. C.: Studies on Taste Thresholds in Normal Man and in Patients With Adrenal Cortical Insufficiency: Role of Adrenal Cortical Steroids and Serum Sodium Concentration , J Clin Invest 42:727, 1963.Crossref 8. Pfaffmann, C., and McBurney, D. H.: Gustatory Adaptation of Salts and Sodium Chloride , J Exp Psych 65:523, 1963.Crossref 9. Pfaffmann, C.: McBurney, D. H.; and Bartosuk, L. M.: Taste of Sodium Chloride Solutions After Adaptation to Sodium Chloride: Implications for "Water Taste," Science 143:967, 1964.Crossref 10. Richter, C. P., and MacLean, A.: Salt Taste Threshold of Humans , Amer J Physiol 126:1, 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1964.02090010374007
Publisher site
See Article on Publisher Site

Abstract

Abstract A great deal of interest has been shown in the sodium chloride taste threshold in humans and its significance, particularly in regard to various disease states, such as cystic fibrosis of the pancreas,6 adrenal cortical insufficiency,7 etc. Many methods have been employed for determining the human salt taste threshold, but the lack of a uniform or standardized approach has resulted in considerable confusion in interpreting the results of such studies. Henkin6,7 reported a significant difference in the salt taste thresholds of patients with cystic fibrosis of the pancreas when compared to those of normals and has suggested that this might be the basis of a diagnostic test for cystic fibrosis of the pancreas. Since the potential value of such a diagnostic procedure was considered to be of great importance, it was deemed advisable to pursue these studies further. For such purposes, it was decided to use as References 1. Burgen, A. S. V., and Emmelin, M. G.: Physiology of Salivary Glands , Baltimore: The Williams & Wilkins Company, 1961, pp 152, 153. 2. Chauncey, H. H., et al: Composition of Human Saliva: Parotid Gland Secretory Rate and Electrolyte Concentration in Children With Cystic Fibrosis , Arch Oral Biol 7:707, 1963.Crossref 3. Fallis, N.; Lasagna, L.; and Tetreault, L.: Gustatory Threshold in Patients With Hypertension , Nature (London) 196:74, 1962.Crossref 4. Harris, H., and Kalmus, H.: Measurement of Taste Sensitivity to Phenylthiourea (PTC) , Ann Eugen (London) 16:226, 1951.Crossref 5. Harris, H.: Introduction to Human Biochemical Genetics , New York: Cambridge Univ. Press, 1953, p 70. 6. Henkin, R. I.: Increased Sensitivity of Taste and Smell in Cystic Fibrosis , Science 138:1107, 1962.Crossref 7. Henkin, R. I.; Gill, J. R.; and Bartter, F. C.: Studies on Taste Thresholds in Normal Man and in Patients With Adrenal Cortical Insufficiency: Role of Adrenal Cortical Steroids and Serum Sodium Concentration , J Clin Invest 42:727, 1963.Crossref 8. Pfaffmann, C., and McBurney, D. H.: Gustatory Adaptation of Salts and Sodium Chloride , J Exp Psych 65:523, 1963.Crossref 9. Pfaffmann, C.: McBurney, D. H.; and Bartosuk, L. M.: Taste of Sodium Chloride Solutions After Adaptation to Sodium Chloride: Implications for "Water Taste," Science 143:967, 1964.Crossref 10. Richter, C. P., and MacLean, A.: Salt Taste Threshold of Humans , Amer J Physiol 126:1, 1939.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1964

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