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R. Biggs (1953)
Thromboplastin Generation TestJ Clin Path, 6
L. Page (1961)
SYLLABUS OF LABORATORY EXAMINATIONS IN CLINICAL DIAGNOSISThe American Journal of the Medical Sciences, 242
Martin Hynes (1958)
Human Blood Coagulation and its DisordersJournal of Clinical Pathology, 11
K. Taylor (1957)
Mildly Affected Female HemophiliacBrit Med J, 1
S. Witte (1965)
[PHYSIOLOGY AND PATHOLOGY OF HEMOSTASIS].Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 20
I. M. Nilsson (1959)
Haemophilia A in "Girl" With Male Sex Chromatin PatternLancet, 2
Mcgovern Jj, Steinberg Ag (1958)
Antihemophilic factor deficiency in the female.Journal of Laboratory and Clinical Medicine, 51
J. Haldane (1947)
The mutation rate of the gene for haemophilia, and its segregation ratios in males and females.Annals of eugenics, 13 4
W. Mellman, I. Wolman, I. Wolman, H. Wurzel, P. Moorhead, Donald Qualls, Donald Qualls (1961)
A chromosomal female with hemophilia A.Blood, 17
Inga Nilsson, Margareta Blombäck, Birger Blombäck (2009)
v. Willebrand's disease in Sweden; its pathogenesis and treatment.Acta medica Scandinavica, 164
Abstract Abnormal bleeding tendency associated with pure antihemophilic globulin (AHG) deficiency is rare in females. To review this subject, one is limited to the past ten years—since the advent of the thromboplastin generation test by Biggs and Douglas.1 If one attempts to evaluate reports of "hemophilia" in females prior to 1953 one can only conclude that there was a first-stage clotting defect which might have been due to a deficiency of any of the first-stage factors. Since 1953, however, there have been a few case reports of excessive bleeding associated with low AHG levels in females from hemophilic families. Nilsson described the interesting case of a white child with classic hemophilia A and family history of AHG deficiency in the maternal line. Although the child was thought to be a female from all external appearances, tissue cultures of skin specimens and cytological studies showed 46 chromosomes with an References 1. Biggs, R., and Douglas, A. S.: Thromboplastin Generation Test , J Clin Path 6:23, 1953.Crossref 2. Nilsson, I. M., et al: Haemophilia A in "Girl" With Male Sex Chromatin Pattern , Lancet 2:264, 1959.Crossref 3. Mellman, W. J., et al: Chromosomal Female With Hemophilia A , Blood 17:719, 1961. 4. McGovern, J. J., and Steinberg, A. G.: Antihemophilic Factor Deficiency in Female , J Lab Clin Med 51:386, 1958. 5. Taylor, K., and Biggs, R.: Mildly Affected Female Hemophiliac , Brit Med J 1:1494, 1957.Crossref 6. Haldane, J. B. S.: Mutation Rate of Gene for Haemophilia and Its Segregation Ratios in Males and Females , Ann Eugen 13:262, 1947.Crossref 7. Choremis, K. B., et al: Helv Paedist Acta 11:305, 1956. 8. Quick, A. J., and Hussey, C. V.: Hemophilic Condition in Girl , Lancet 1:294, 1958. 9. Braun, E. H., and Stollar, D. B.: Spontaneous Haemophilia in Female , Thromb Diath Haemorrh 4:369, 1960. 10. Quick, A. J.: Physiology and Pathology of Hemostasis , Philadelphia: Lea & Febiger, 1951. 11. Ham, T., ed.: Syllabus of Laboratory Examinations in Clinical Diagnosis , Cambridge, Mass: Harvard University Press, 1953. 12. Biggs, R., and Macfarlane, R. G.: Human Blood Coagulation and Its Disorders , ed 2, Springfield, Ill: Charles C Thomas Publisher, 1957, 421-423. 13. Egeberg, O.: Conditions Associated With Increased Blood Antihemophilic Factor (F. VIII) Activity, read before the International Conference on Hemophilia at Washington DC, Dec 1963. 14. Jones, J. H., et al: Combined Deficiency of Factor V and Factor VIII , Brit J Haemat 8:120, 1962.Crossref 15. Nilsson, I. M.; Blombach, M.; and Blombach, B.: von Willebrand's Disease in Sweden: Its Pathogenesis and Treatment , Acta Med Scand 164:263, 1959.Crossref 16. Cornu, P., et al: Transfusion Studies in von Willebrand's Diseases: Effect on Bleeding Time and Factor VIII , Brit J Haemat 9:189, 1963.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Sep 1, 1964
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