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Immunization with Live Attenuated Poliovirus Vaccine

Immunization with Live Attenuated Poliovirus Vaccine Abstract Live attenuated poliovirus vaccine was administered to 400 newborn infants during a three-month period (October, 1959, to January, 1960). This study was designed to obtain information which might provide answers to the following questions. Would the ingestion of larger doses permit enough of the vaccine viruses regularly to pass the "acid barrier" of the stomach of newborn infants and result in regular multiplication in the intestinal tract? (Poliovirus may be destroyed below a pH of 2.5 and the gastric contents of newborns often have a pH of about 1.5.)1-3 Would it be possible to by-pass the potential handicap of high gastric acidity by swabbing the vaccine directly on the posterior pharyngeal wall? Would all three types multiply following administration of a mixture of large doses of Types 1, 2, and 3 poliovirus either by mouth or by throat as determined by virus excretion and antibody formation? Materials References 1. Tangle, F.: Untersuchunger über die Hydrogenienen Conzentration im Inhalte des nuchternen menschlichen Magens , Arch. ges. Physiol. 115:64, 1906.Crossref 2. Griswold, C., and Shohl, A. T. C.: Gastric Digestion in New-Born Infants , A.J. Dis. Child. 30:541, 1925. 3. Ebers, D. W.; Smith, D. I., and Gibbs, G. E.: Gastric Acidity on the First Day of Life , Pediatrics 18:800, 1956. 4. Sabin, A. B.: Status of Field Trials with an Orally Administered Live Attenuated Poliovirus Vaccine , J.A.M.A. 171:863, ( (Oct. 17) ) 1959.Crossref 5. Sabin, A. B.; Krumbiegel, E. R., and Wigand, R.: ECHO Type 9 Virus Disease , A.M.A. J. Dis. Child. 96:197, 1958.Crossref 6. Sabin, A. B.: Unpublished data. 7. Gelfand, H.: Personal communication (unpublished studies). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Immunization with Live Attenuated Poliovirus Vaccine

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1961.04020020025005
Publisher site
See Article on Publisher Site

Abstract

Abstract Live attenuated poliovirus vaccine was administered to 400 newborn infants during a three-month period (October, 1959, to January, 1960). This study was designed to obtain information which might provide answers to the following questions. Would the ingestion of larger doses permit enough of the vaccine viruses regularly to pass the "acid barrier" of the stomach of newborn infants and result in regular multiplication in the intestinal tract? (Poliovirus may be destroyed below a pH of 2.5 and the gastric contents of newborns often have a pH of about 1.5.)1-3 Would it be possible to by-pass the potential handicap of high gastric acidity by swabbing the vaccine directly on the posterior pharyngeal wall? Would all three types multiply following administration of a mixture of large doses of Types 1, 2, and 3 poliovirus either by mouth or by throat as determined by virus excretion and antibody formation? Materials References 1. Tangle, F.: Untersuchunger über die Hydrogenienen Conzentration im Inhalte des nuchternen menschlichen Magens , Arch. ges. Physiol. 115:64, 1906.Crossref 2. Griswold, C., and Shohl, A. T. C.: Gastric Digestion in New-Born Infants , A.J. Dis. Child. 30:541, 1925. 3. Ebers, D. W.; Smith, D. I., and Gibbs, G. E.: Gastric Acidity on the First Day of Life , Pediatrics 18:800, 1956. 4. Sabin, A. B.: Status of Field Trials with an Orally Administered Live Attenuated Poliovirus Vaccine , J.A.M.A. 171:863, ( (Oct. 17) ) 1959.Crossref 5. Sabin, A. B.; Krumbiegel, E. R., and Wigand, R.: ECHO Type 9 Virus Disease , A.M.A. J. Dis. Child. 96:197, 1958.Crossref 6. Sabin, A. B.: Unpublished data. 7. Gelfand, H.: Personal communication (unpublished studies).

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jan 1, 1961

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