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S. Barker, M. Humphrey, M. Soley (1951)
The clinical determination of protein-bound iodine.The Journal of clinical investigation, 30 1
R. Mccarrison (1933)
The goitrogenic action of soya-bean and ground-nut.Indian Journal of Medical Research, 21
T. Shepard, G. Pyne, J. Kirschvink, M. McLean (1960)
Soybean goiter: report of three cases.The New England Journal of Medicine, 262
A. Halverson, M. Zepplin, E. Hart (1949)
Relation of iodine to the goitrogenic properties of soybeans.The Journal of nutrition, 38 2
G. Sharpless, J. Pearsons, Geneva Prato (1939)
Production of Goiter in Rats with Raw and with Treated Soy Bean FlourJournal of Nutrition, 17
G. Sharpless (1938)
A New Goiter-Producing Diet for the RatProceedings of the Society for Experimental Biology and Medicine, 38
T. H. Shepard , G. E. Pyne, J. F. Kirkschvink (1960)
Soybean Goiter: Report of 3 CasesNew England J. Med., 262
H. Wilgus, F. Gassner, A. Patton, R. Gustavson (1941)
The goitrogenicity of soybeans.Journal of Nutrition, 22
J. Hydovitz (1960)
Occurrence of goiter in an infant on a soy diet.The New England journal of medicine, 262
J. Wyk, M. Arnold, J. Wynn, F. Pepper (1959)
The effects of a soybean product on thyroid function in humans.Pediatrics, 24
Abstract The goitrogenic effect of soybean diets in animals has been recognized for some 25 years.1 The fact that these effects can be modified by heat, organic solvent extraction, or the addition of iodine4,5 suggested that a specific goitrogenic substance was present in soybeans. Until recently, only one case of goiter in an infant had been reported.6 In a recent comprehensive article, Van Wyck et al.7 described a 10-month-old female infant who was observed and studied after having developed a goiter and mild hypothyroidism while on a soybean milk product. Their studies suggested that a goitrogenic agent which interfered with hormonal synthesis in certain susceptible individuals was present in soybeans. Hydovitz8 discussed the appearance of thyroid enlargement in a 4½-month-old male infant maintained on a soybean extract and the subsequent disappearance of the enlargement after the elimination of this nutrient. Shepard et al.9 reported 3 References 1. McCarrison, R.: The Goitrogenic Action of Soya-Bean and Ground-Nut , Indian J.M. Res. 21: 179, 1933. 2. Sharpless, G. R.: A New Goiter Producing Diet for the Rat , Proc. Soc. Exper. Biol. & Med. 38:166, 1938. 3. Wilgus, H. S.; Gassner, F. X.; Patton, A. R., and Gustavson, R. C.: The Goitrogenicity of Soybeans , J. Nutrition 22:43, 1941. 4. Halverson, A. W.; Zepplin, M., and Hart, E. B.: Relation of Iodine to the Goitrogenic Properties of Soybeans , J. Nutrition 38:115, 1949. 5. Sharpless, G. R.; Pearsons, J., and Prato, G. S.: Production of Goiter in Rats with Raw and with Treated Soybean Flour , J. Nutrition 17: 545, 1939. 6. Rawson, R.: In Recent Progr. Hormone Res. 11:273, 1955. 7. Van Wyck, J. J.; Arnold, M. B.; Wynn, J., and Pepper, F.: The Effects of a Soybean Product on Thyroid Function in Humans , Pediatrics 24: 752, 1959. 8. Hydovitz, J. D.: Occurrence of Goiter in an Infant on a Soy Diet , New England J. Med. 262:351-352, 1960. 9. Shepard, T. H.; Pyne, G. E.; Kirkschvink, J. F., and McLean, M.: Soybean Goiter: Report of 3 Cases , New England J. Med. 262:1099, 1960. 10. Barker, S. B.; Humphrey, M. J., and Soley, M. H.: The Clinical Determination of Protein-Bound Iodine , J. Clin. Invest. 30:55-62, 1951.
American Journal of Diseases of Children – American Medical Association
Published: Jul 1, 1961
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