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The Nonspecific Inflammatory Cycle in the Neonatal Infant

The Nonspecific Inflammatory Cycle in the Neonatal Infant Abstract The failure of the newborn animal and human infant to exhibit the usual signs of inflammation in response to foreign substances is documented in the experimental and clinical literature. For example, Adelsberger,1 Rachmilewitsch,2 and Friedberger and Heim3 showed that such exotic irritants as croton oil, mustard oil, or eel serum failed to elicit the usual violent inflammatory reaction when applied to the skin of the neonatal infant. Von Groër and Kassowitz4 and Cooke5 found that the Schick and Dick toxin reactions are suppressed in the young infant independent of the presence or absence of specific antitoxin in the serum. Similar observations in newborn animals have indicated not only that there is a failure of response to nonspecific irritants, but that bacterial or viral skin infections often fail to elicit the usual mature local response6 leading to systemic dissemination of the agent. Evidence is also References 1. Adelsberger, L.: Das Verhalten der kindlichen Haut gegenüber verschiedenen Reizen , Ztschr. Kinderh. 43:373-390, 1927.Crossref 2. Rachmilewitsch, E.: Hautreaktionen von Kindern mit exudativer Diathese , Jahrb. Kinderh. 77:176-180, 1913. 3. Friedberger, E., and Heim, F.: Zur Deutung der negativen Schickschen Reaktion, insbesondere bei Saüglingen , Deutsche med. Wchnschr. 55:132-133, 1929.Crossref 4. von Groër and Kassowitz: Studien über die normale Diphtherieimmunität des Menschen: II. Über das verhalten des normalen Diphtherie-antitoxins bei Mutter und Neugeborenem , Ztschr. Immunitätsforsch. 23:108-126, 1914. 5. Cooke, J. V.: Scarlet Fever: I. The Relation Between Antitoxin in the Blood and Skin Sensitivity to Toxin in New-Born Infants and in their Mothers , Am. J. Dis. Child. 34:969-978, 1927.Crossref 6. Freund, J.: Reaction of Young and Adult Rabbits to Pneumococci Injected into the Skin , J. Exper. Med. 54:171-180, 1931.Crossref 7. Smith, R. T.; Platou, E. S., and Good, R. A.: Septicemia of the Newborn: Current Status of the Problem , Pediatrics 17:549-575, 1956. 8. Rebuck, J., and Crowley, J.: A Method of Studying Leukocytic Functions in Vivo , Ann. New York Acad. Sc. 59:757-805, 1955.Crossref 9. Menkin, V.: Biochemical Mechanisms in Inflammation , Publication No. 288, American Lecture Series, edited by E. Ryan, Springfield, Ill., Charles C Thomas, Publisher, 1956. 10. Gluck, L., and Silverman, W.: Phagocytosis in Premature Infants , Pediatrics 20:951-957, 1957. 11. Polak, H., and Polakova, K.: Indirect Evidence of a Factor Increasing the Motility of Leucocytes , Acta haemat . 16:385-395, 1956.Crossref 12. Harris, J., and Schick, B.: Erythema Neonatorum , A. M. A. J. Dis. Child. 92:27-33, 1956. 13. Mayerhofer, E., and Lypolt-Krajnović, M.: Das Erythema neonatorum toxicum-Leiner ("Erythema Papulatum" der alten Aerzte) als Teilerscheinung einer allgemeinen Allergie des Neugeborenen , Ztschr. Kinderh. 43:630-657, 1927.Crossref 14. Matheson, A.; Rosenblum, A.; Glazer, R., and Ducanay, E.: Local Tissue and Blood Eosinophils in Newborn Infants , J. Pediat. 51:502-509, 1957.Crossref 15. Medoff, H., and Barberq, G.: Total Blood Eosinophil Counts in the Newborn Period , Pediatrics 6:737-742, 1950. 16. Lippman, H.: A Morphologic and Quantitative Study of the Blood Corpuscles in the New-Born Period , Am. J. Dis. Child. 27:473-526, 1924. 17. Campbell, D.: Relationships of the Eosinophil Response to Factors Involved in Anaphylaxia , J. Infect. Dis. 72:42-48, 1943.Crossref 18. Speirs, R. S.: Physiological Approaches to an Understanding of the Function of Eosinophils and Basophils , Ann. New York Acad. Sc. 59:705-731, 1955.Crossref 19. Venning, E.; Randall, J., and Gyorgy, P.: Excretion of Glucorticoids in the Newborn , Endocrinology 45:430-434, 1949.Crossref 20. Gardner, L.: Adrenal Function in the Premature and Newborn , Pediatrics 17:414-417, 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

The Nonspecific Inflammatory Cycle in the Neonatal Infant

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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1959.02070010328011
Publisher site
See Article on Publisher Site

Abstract

Abstract The failure of the newborn animal and human infant to exhibit the usual signs of inflammation in response to foreign substances is documented in the experimental and clinical literature. For example, Adelsberger,1 Rachmilewitsch,2 and Friedberger and Heim3 showed that such exotic irritants as croton oil, mustard oil, or eel serum failed to elicit the usual violent inflammatory reaction when applied to the skin of the neonatal infant. Von Groër and Kassowitz4 and Cooke5 found that the Schick and Dick toxin reactions are suppressed in the young infant independent of the presence or absence of specific antitoxin in the serum. Similar observations in newborn animals have indicated not only that there is a failure of response to nonspecific irritants, but that bacterial or viral skin infections often fail to elicit the usual mature local response6 leading to systemic dissemination of the agent. Evidence is also References 1. Adelsberger, L.: Das Verhalten der kindlichen Haut gegenüber verschiedenen Reizen , Ztschr. Kinderh. 43:373-390, 1927.Crossref 2. Rachmilewitsch, E.: Hautreaktionen von Kindern mit exudativer Diathese , Jahrb. Kinderh. 77:176-180, 1913. 3. Friedberger, E., and Heim, F.: Zur Deutung der negativen Schickschen Reaktion, insbesondere bei Saüglingen , Deutsche med. Wchnschr. 55:132-133, 1929.Crossref 4. von Groër and Kassowitz: Studien über die normale Diphtherieimmunität des Menschen: II. Über das verhalten des normalen Diphtherie-antitoxins bei Mutter und Neugeborenem , Ztschr. Immunitätsforsch. 23:108-126, 1914. 5. Cooke, J. V.: Scarlet Fever: I. The Relation Between Antitoxin in the Blood and Skin Sensitivity to Toxin in New-Born Infants and in their Mothers , Am. J. Dis. Child. 34:969-978, 1927.Crossref 6. Freund, J.: Reaction of Young and Adult Rabbits to Pneumococci Injected into the Skin , J. Exper. Med. 54:171-180, 1931.Crossref 7. Smith, R. T.; Platou, E. S., and Good, R. A.: Septicemia of the Newborn: Current Status of the Problem , Pediatrics 17:549-575, 1956. 8. Rebuck, J., and Crowley, J.: A Method of Studying Leukocytic Functions in Vivo , Ann. New York Acad. Sc. 59:757-805, 1955.Crossref 9. Menkin, V.: Biochemical Mechanisms in Inflammation , Publication No. 288, American Lecture Series, edited by E. Ryan, Springfield, Ill., Charles C Thomas, Publisher, 1956. 10. Gluck, L., and Silverman, W.: Phagocytosis in Premature Infants , Pediatrics 20:951-957, 1957. 11. Polak, H., and Polakova, K.: Indirect Evidence of a Factor Increasing the Motility of Leucocytes , Acta haemat . 16:385-395, 1956.Crossref 12. Harris, J., and Schick, B.: Erythema Neonatorum , A. M. A. J. Dis. Child. 92:27-33, 1956. 13. Mayerhofer, E., and Lypolt-Krajnović, M.: Das Erythema neonatorum toxicum-Leiner ("Erythema Papulatum" der alten Aerzte) als Teilerscheinung einer allgemeinen Allergie des Neugeborenen , Ztschr. Kinderh. 43:630-657, 1927.Crossref 14. Matheson, A.; Rosenblum, A.; Glazer, R., and Ducanay, E.: Local Tissue and Blood Eosinophils in Newborn Infants , J. Pediat. 51:502-509, 1957.Crossref 15. Medoff, H., and Barberq, G.: Total Blood Eosinophil Counts in the Newborn Period , Pediatrics 6:737-742, 1950. 16. Lippman, H.: A Morphologic and Quantitative Study of the Blood Corpuscles in the New-Born Period , Am. J. Dis. Child. 27:473-526, 1924. 17. Campbell, D.: Relationships of the Eosinophil Response to Factors Involved in Anaphylaxia , J. Infect. Dis. 72:42-48, 1943.Crossref 18. Speirs, R. S.: Physiological Approaches to an Understanding of the Function of Eosinophils and Basophils , Ann. New York Acad. Sc. 59:705-731, 1955.Crossref 19. Venning, E.; Randall, J., and Gyorgy, P.: Excretion of Glucorticoids in the Newborn , Endocrinology 45:430-434, 1949.Crossref 20. Gardner, L.: Adrenal Function in the Premature and Newborn , Pediatrics 17:414-417, 1956.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1959

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