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Studies on Copper Metabolism: XXIV. Hypocupremia in Infancy

Studies on Copper Metabolism: XXIV. Hypocupremia in Infancy Abstract Hypocupremia has been observed occasionally in patients with severe microcytic hypochromic anemia due to iron deficiency,1-5 but as a rule the serum copper is increased in iron deficiency.1,6 It was, therefore, of interest when Sturgeon and Brubaker7; Ulstrom, Smith and Heimlich,8 and Lahey9 described a syndrome characterized by hypocupremia, hypoferremia, hypoproteinemia, edema, and hypochromic microcytic anemia in a total of 19 infants and children. Sturgeon and Brubaker7 treated one of their patients with copper and noted a prompt increase in serum copper but no increase in hemoglobin, reticulocytes, or serum proteins. Lahey9 made a similar observation in two of his patients. In addition, Lahey observed that the administration of iron alone was followed by a prompt reticulocystosis, alleviation of anemia, and an increase in serum proteins but no increase in serum copper. The diets of the patients studied by Sturgeon and Brubaker and References 1. Axtrup, S.: The Blood Copper in Anaemias of Children with Special Reference to Premature Cases , Lund, Sweden, P. H. Lindstedt Universitets Bokhandel, 1946. 2. Stransky, E.; Dauis-Lawas, D. T., and Lawas, I. L.: On Serum Copper Level and Its Importance in Childhood , Ann. paediat. 179:1, 1952. 3. De Vries, S. I.: De betekenis van koper bij de behandeling van tegen ijzer refractaire hypochrome anaemie , Nederl. tijdschr. geneesk. 96: 611, 1952. 4. Zurukzoglu-Sklavounou, S.: Hypochrome Anämie im Kindesalter: Studie auf Grund von 373 Fällen , Helvet. paediat. acta 8:251, 1953. 5. Hasegawa, M., and Ito, S.: The Importance of Copper in the Treatment of Anemia , Keio J. Med. 3:25, 1954.Crossref 6. Lahey, M. E.; Gubler, C. J.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: VII. Blood Copper in Pregnancy and Various Pathologic States , J. Clin. Invest. 32:329, 1953.Crossref 7. Sturgeon, P., and Brubaker, C.: Copper Deficiency in Infants: A Syndrome Characterized by Hypocupremia, Iron Deficiency Anemia, and Hypoproteinemia , A. M. A. J. Dis. Child. 92:254, 1956.Crossref 8. Ulstrom, R. A.; Smith, N. J., and Heimlich, E. M.: Transient Dysproteinemia in Infants, a New Syndrome: I. Clinical Studies , A. M. A. J. Dis. Child. 92:219, 1956.Crossref 9. Lahey, M. E.: Iron and Copper in Infant Nutrition , Am. J. Clin. Nutrition 5:516, 1957. 10. Lahey, M. E., and Schubert, W. K.: New Deficiency Syndrome Occurring in Infancy , A. M. A. J. Dis. Child. 93:31, 1957. 11. Gubler, C. J.; Lahey, M. E.; Ashenbrucker, H.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: I. A Method for the Determination of Copper in Whole Blood, Red Blood Cells and Plasma , J. Biol. Chem. 196:209, 1952. 12. Markowitz, H.; Gubler, C. J.; Mahoney, J. P.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: XIV. Copper, Ceruloplasmin and Oxidase Activity in Sera of Normal Human Subjects, Pregnant Women, and Patients with Infection, Hepatolenticular Degeneration, and the Nephrotic Syndrome , J. Clin. Invest. 34:1498, 1955.Crossref 13. Hamilton, L. D.; Gubler, C. J.; Cartwright, G. E., and Wintrobe, M. M.: Diurnal Variation in Plasma Iron Level in Man , Proc. Soc. Exper. Biol. & Med. 75:65, 1950. 14. Cartwright, G. E., and Wintrobe, M. M.: Chemical, Clinical, and Immunological Studies on the Products of Plasma Fractionation: XXXIX. The Anemia of Infection; Studies on the Iron Binding Capacity of the Serum , J. Clin. Invest. 28:86, 1949. 15. Gubler, C. J.; Brown, H.; Markowitz, H.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: XXIII. Portal (Laennec's) Cirrhosis of the Liver , J. Clin. Invest. 36: 1208, 1957. 16. Gornall, A.; Bardawill, C., and David, M.: Determination of Serum Proteins By Means of the Biuret Reaction , J. Biol. Chem. 177:751, 1949. 17. Weichselbaum, T. E.: An Accurate and Rapid Method for the Determination of Proteins in Small Amounts of Blood Serum and Plasma , Am. J. Clin. Path., Tech. Sec. 16:40, 1946. 18. Gould, B. S., and Shwachman, H.: Studies in Cystic Fibrosis: Determination of Plasma Proteins Following Protein Feeding as a Diagnostic Test for Pancreatic Insufficiency , A. M. A. J. Dis. Child. 91:584, 1956. 19. Oberman, J. W.; Gregory, K. O.; Burke, F. G.; Ross, S., and Rice, E. C.: Electrophoretic Analysis of Serum Proteins in Infants and Children: I. Normal Values From Birth to Adolescence , New England J. Med. 255:743, 1956. 20. Sturgeon, P.: Studies on Iron Requirements in Infants and Children: I. Normal Values for Serum Iron, Copper and Free Erythrocyte Protoporphyrin , Pediatrics 13:107, 1954. 21. Gubler, C. J.; Lahey, M. E.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: IX. The Transportation of Copper in Blood , J. Clin. Invest. 32:405, 1953. 22. Lahey, M. E.; Gubler, C. J.; Chase, M. S.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: II. Hematological Manifestations of Copper Deficiency in Swine , Blood 7:1053, 1952. 23. Gubler, C. J.; Lahey, M. E.; Chase, M. S.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: III. The Metabolism of Iron in Copper Deficient Swine , Blood 7:1075, 1952. 24. Gubler, C. J.; Lahey, M. E.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: X. Factors Influencing the Plasma Copper Level of the Albino Rat , Am. J. Physiol. 171:652, 1952. 25. Cartwright, G. E., and Wintrobe, M. M.: Studies on Free Erythrocyte Protoporphyrin, Plasma Copper, and Plasma Iron in Protein-Deficient and Iron-Deficient Swine , J. Biol. Chem. 176:571, 1948. 26. Ulstrom, R. A.; Smith, N. J.; Nakamura, K., and Heimlich, E.: Transient Dysproteinemia in Infants: II. Studies on Protein Metabolism Using Amino Acid Isotopes , A. M. A. J. Dis. Child. 93: 536, 1957.Crossref 27. Cartwright, G. E.: Copper Metabolism in Human Subjects , in Copper Metabolism: A Symposium on Animal, Plant, and Soil Relationships , edited by W. D. McElroy and B. Glass, Baltimore, The Johns Hopkins Press, 1950, p. 274. 28. Scheinberg, I. H.; Cook, C. D., and Murphy, J. A.: The Concentration of Copper and Ceruloplasmin in Maternal and Infant Plasma at Delivery , J. Clin. Invest. 33:963, 1954. 29. Bearn, A. G.: Wilson's Disease: An Inborn Error of Metabolism with Multiple Manifestations , Am. J. Med. 22:747, 1957.Crossref 30. Butterworth, C. E.; Cartwright, G. E.; Gubler, C. J., and Wintrobe, M. M.: Unpublished data. 31. Cartwright, G. E.: The Relationship of Copper, Cobalt, and Other Trace Elements to Hemopoiesis , Am. J. Clin. Nutrition 3:11, 1955. 32. Cartwright, G. E.; Gubler, C. J., and Wintrobe, M. M.: Studies on Copper Metabolism: XI. Copper and Iron Metabolism in the Nephrotic Syndrome , J. Clin. Invest. 33:685, 1954.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Studies on Copper Metabolism: XXIV. Hypocupremia in Infancy

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References (38)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1958.02060060150004
Publisher site
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Abstract

Abstract Hypocupremia has been observed occasionally in patients with severe microcytic hypochromic anemia due to iron deficiency,1-5 but as a rule the serum copper is increased in iron deficiency.1,6 It was, therefore, of interest when Sturgeon and Brubaker7; Ulstrom, Smith and Heimlich,8 and Lahey9 described a syndrome characterized by hypocupremia, hypoferremia, hypoproteinemia, edema, and hypochromic microcytic anemia in a total of 19 infants and children. Sturgeon and Brubaker7 treated one of their patients with copper and noted a prompt increase in serum copper but no increase in hemoglobin, reticulocytes, or serum proteins. Lahey9 made a similar observation in two of his patients. In addition, Lahey observed that the administration of iron alone was followed by a prompt reticulocystosis, alleviation of anemia, and an increase in serum proteins but no increase in serum copper. The diets of the patients studied by Sturgeon and Brubaker and References 1. Axtrup, S.: The Blood Copper in Anaemias of Children with Special Reference to Premature Cases , Lund, Sweden, P. H. Lindstedt Universitets Bokhandel, 1946. 2. Stransky, E.; Dauis-Lawas, D. T., and Lawas, I. L.: On Serum Copper Level and Its Importance in Childhood , Ann. paediat. 179:1, 1952. 3. De Vries, S. I.: De betekenis van koper bij de behandeling van tegen ijzer refractaire hypochrome anaemie , Nederl. tijdschr. geneesk. 96: 611, 1952. 4. Zurukzoglu-Sklavounou, S.: Hypochrome Anämie im Kindesalter: Studie auf Grund von 373 Fällen , Helvet. paediat. acta 8:251, 1953. 5. Hasegawa, M., and Ito, S.: The Importance of Copper in the Treatment of Anemia , Keio J. Med. 3:25, 1954.Crossref 6. Lahey, M. E.; Gubler, C. J.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: VII. Blood Copper in Pregnancy and Various Pathologic States , J. Clin. Invest. 32:329, 1953.Crossref 7. Sturgeon, P., and Brubaker, C.: Copper Deficiency in Infants: A Syndrome Characterized by Hypocupremia, Iron Deficiency Anemia, and Hypoproteinemia , A. M. A. J. Dis. Child. 92:254, 1956.Crossref 8. Ulstrom, R. A.; Smith, N. J., and Heimlich, E. M.: Transient Dysproteinemia in Infants, a New Syndrome: I. Clinical Studies , A. M. A. J. Dis. Child. 92:219, 1956.Crossref 9. Lahey, M. E.: Iron and Copper in Infant Nutrition , Am. J. Clin. Nutrition 5:516, 1957. 10. Lahey, M. E., and Schubert, W. K.: New Deficiency Syndrome Occurring in Infancy , A. M. A. J. Dis. Child. 93:31, 1957. 11. Gubler, C. J.; Lahey, M. E.; Ashenbrucker, H.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: I. A Method for the Determination of Copper in Whole Blood, Red Blood Cells and Plasma , J. Biol. Chem. 196:209, 1952. 12. Markowitz, H.; Gubler, C. J.; Mahoney, J. P.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: XIV. Copper, Ceruloplasmin and Oxidase Activity in Sera of Normal Human Subjects, Pregnant Women, and Patients with Infection, Hepatolenticular Degeneration, and the Nephrotic Syndrome , J. Clin. Invest. 34:1498, 1955.Crossref 13. Hamilton, L. D.; Gubler, C. J.; Cartwright, G. E., and Wintrobe, M. M.: Diurnal Variation in Plasma Iron Level in Man , Proc. Soc. Exper. Biol. & Med. 75:65, 1950. 14. Cartwright, G. E., and Wintrobe, M. M.: Chemical, Clinical, and Immunological Studies on the Products of Plasma Fractionation: XXXIX. The Anemia of Infection; Studies on the Iron Binding Capacity of the Serum , J. Clin. Invest. 28:86, 1949. 15. Gubler, C. J.; Brown, H.; Markowitz, H.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: XXIII. Portal (Laennec's) Cirrhosis of the Liver , J. Clin. Invest. 36: 1208, 1957. 16. Gornall, A.; Bardawill, C., and David, M.: Determination of Serum Proteins By Means of the Biuret Reaction , J. Biol. Chem. 177:751, 1949. 17. Weichselbaum, T. E.: An Accurate and Rapid Method for the Determination of Proteins in Small Amounts of Blood Serum and Plasma , Am. J. Clin. Path., Tech. Sec. 16:40, 1946. 18. Gould, B. S., and Shwachman, H.: Studies in Cystic Fibrosis: Determination of Plasma Proteins Following Protein Feeding as a Diagnostic Test for Pancreatic Insufficiency , A. M. A. J. Dis. Child. 91:584, 1956. 19. Oberman, J. W.; Gregory, K. O.; Burke, F. G.; Ross, S., and Rice, E. C.: Electrophoretic Analysis of Serum Proteins in Infants and Children: I. Normal Values From Birth to Adolescence , New England J. Med. 255:743, 1956. 20. Sturgeon, P.: Studies on Iron Requirements in Infants and Children: I. Normal Values for Serum Iron, Copper and Free Erythrocyte Protoporphyrin , Pediatrics 13:107, 1954. 21. Gubler, C. J.; Lahey, M. E.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: IX. The Transportation of Copper in Blood , J. Clin. Invest. 32:405, 1953. 22. Lahey, M. E.; Gubler, C. J.; Chase, M. S.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: II. Hematological Manifestations of Copper Deficiency in Swine , Blood 7:1053, 1952. 23. Gubler, C. J.; Lahey, M. E.; Chase, M. S.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: III. The Metabolism of Iron in Copper Deficient Swine , Blood 7:1075, 1952. 24. Gubler, C. J.; Lahey, M. E.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: X. Factors Influencing the Plasma Copper Level of the Albino Rat , Am. J. Physiol. 171:652, 1952. 25. Cartwright, G. E., and Wintrobe, M. M.: Studies on Free Erythrocyte Protoporphyrin, Plasma Copper, and Plasma Iron in Protein-Deficient and Iron-Deficient Swine , J. Biol. Chem. 176:571, 1948. 26. Ulstrom, R. A.; Smith, N. J.; Nakamura, K., and Heimlich, E.: Transient Dysproteinemia in Infants: II. Studies on Protein Metabolism Using Amino Acid Isotopes , A. M. A. J. Dis. Child. 93: 536, 1957.Crossref 27. Cartwright, G. E.: Copper Metabolism in Human Subjects , in Copper Metabolism: A Symposium on Animal, Plant, and Soil Relationships , edited by W. D. McElroy and B. Glass, Baltimore, The Johns Hopkins Press, 1950, p. 274. 28. Scheinberg, I. H.; Cook, C. D., and Murphy, J. A.: The Concentration of Copper and Ceruloplasmin in Maternal and Infant Plasma at Delivery , J. Clin. Invest. 33:963, 1954. 29. Bearn, A. G.: Wilson's Disease: An Inborn Error of Metabolism with Multiple Manifestations , Am. J. Med. 22:747, 1957.Crossref 30. Butterworth, C. E.; Cartwright, G. E.; Gubler, C. J., and Wintrobe, M. M.: Unpublished data. 31. Cartwright, G. E.: The Relationship of Copper, Cobalt, and Other Trace Elements to Hemopoiesis , Am. J. Clin. Nutrition 3:11, 1955. 32. Cartwright, G. E.; Gubler, C. J., and Wintrobe, M. M.: Studies on Copper Metabolism: XI. Copper and Iron Metabolism in the Nephrotic Syndrome , J. Clin. Invest. 33:685, 1954.Crossref

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Aug 1, 1958

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