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Simultaneous Occurrence of Mongolism and Leukemia: Report of a Nationwide Survey

Simultaneous Occurrence of Mongolism and Leukemia: Report of a Nationwide Survey Abstract The reports of the simultaneous occurrence of leukemia and Mongolism by Schunk (two cases),1 Bernhard (three cases),2 Krivit and Good (five cases),3 and Merrit and Harris (four cases) 4 and the personal communications of Dr. Sydney Farber (eight cases) and Dr. James Wolff (four cases) prompted a nationwide survey to determine the incidence of this entity. The observation of a surprisingly large number of patients with concomitant leukemia and Mongolism was indeed intriguing and provoked an effort to determine whether or not the joint occurrence of these two diseases was fortuitous or biologically significant. It was reasoned that if this surprising combination of unusual diseases were found to occur more frequently than could be explained by chance, a common denominator for the two disorders might be sought. For example, among the etiologic possibilities one might consider teratogenic forces (i. e., virus infection, nutritional factors, toxicity, or stress) References 1. Schunk, G. J., and Lehman, W. L.: Mongolism and Congenital Leukemia , J. A. M. A. 155: 250-251, 1954.Crossref 2. Bernhard, W. G.; Gore, I., and Kilby, R. A.: Congenital Leukemia , Blood 6:990-1001, 1951. 3. Krivit, W., and Good, R. A.: The Simultaneous Occurrence of Leukemia and Mongolism: Report of 4 cases , A. M. A. J. Dis. Child. 91:218-222, 1956.Crossref 4. Merrit, D. H., and Harris, J. S.: Mongolism and Acute Leukemia: A Report of 4 Cases , A. M.A.J. Dis. Child. 92:41-44, 1956.Crossref 5. Beidelman, B.: Mongolism: A Selective Review , Am. J. Ment. Deficiency 50:35, 1945-1946. 6. Carter, C., and MacCarthy, D.: Incidence of Mongolism and Its Diagnosis in the Newborn , Brit. J. Soc. Med. 5:83-90, 1951. 7. Population by Age Group , in Vital Statistics of the United States , United States Department of Health, Education, and Welfare, 1952, 1953, and 1954, Vol. 1. 8. Death by Specific Disease According to Age , in Vital Statistics of the United States , United States Department of Health, Education, and Welfare, 1952, 1953, and 1954, Vol. 2, p. 64. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Simultaneous Occurrence of Mongolism and Leukemia: Report of a Nationwide Survey

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1957.04030040075012
Publisher site
See Article on Publisher Site

Abstract

Abstract The reports of the simultaneous occurrence of leukemia and Mongolism by Schunk (two cases),1 Bernhard (three cases),2 Krivit and Good (five cases),3 and Merrit and Harris (four cases) 4 and the personal communications of Dr. Sydney Farber (eight cases) and Dr. James Wolff (four cases) prompted a nationwide survey to determine the incidence of this entity. The observation of a surprisingly large number of patients with concomitant leukemia and Mongolism was indeed intriguing and provoked an effort to determine whether or not the joint occurrence of these two diseases was fortuitous or biologically significant. It was reasoned that if this surprising combination of unusual diseases were found to occur more frequently than could be explained by chance, a common denominator for the two disorders might be sought. For example, among the etiologic possibilities one might consider teratogenic forces (i. e., virus infection, nutritional factors, toxicity, or stress) References 1. Schunk, G. J., and Lehman, W. L.: Mongolism and Congenital Leukemia , J. A. M. A. 155: 250-251, 1954.Crossref 2. Bernhard, W. G.; Gore, I., and Kilby, R. A.: Congenital Leukemia , Blood 6:990-1001, 1951. 3. Krivit, W., and Good, R. A.: The Simultaneous Occurrence of Leukemia and Mongolism: Report of 4 cases , A. M. A. J. Dis. Child. 91:218-222, 1956.Crossref 4. Merrit, D. H., and Harris, J. S.: Mongolism and Acute Leukemia: A Report of 4 Cases , A. M.A.J. Dis. Child. 92:41-44, 1956.Crossref 5. Beidelman, B.: Mongolism: A Selective Review , Am. J. Ment. Deficiency 50:35, 1945-1946. 6. Carter, C., and MacCarthy, D.: Incidence of Mongolism and Its Diagnosis in the Newborn , Brit. J. Soc. Med. 5:83-90, 1951. 7. Population by Age Group , in Vital Statistics of the United States , United States Department of Health, Education, and Welfare, 1952, 1953, and 1954, Vol. 1. 8. Death by Specific Disease According to Age , in Vital Statistics of the United States , United States Department of Health, Education, and Welfare, 1952, 1953, and 1954, Vol. 2, p. 64.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1957

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