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W. Bradford, Elizabeth Day (1945)
Therapeutic Effect of Streptomycin in Experimental Murine Pertussis.∗Proceedings of the Society for Experimental Biology and Medicine, 60
J. Kohn, G. Rudel (1947)
Hyperimmune serums in treatment of whooping cough; clinical results, with notes on bacteriologic studies and cutaneous tests.American journal of diseases of children, 74 3
V. Bryson, E. Grace (1947)
Aerosol therapy of respiratory disease; a report of fifty cases.The New England journal of medicine, 237 19
Abramson Ha (1946)
Principles and, practice of aerosol therapy of the lungs and bronchi.Annals of allergy, 4
J. Kohn, A. Fischer (1947)
Management of whooping cough with special reference to infants.American journal of diseases of children, 73 6
THE ESSENTIAL procedures in the treatment of whooping cough, which included the use of human hyperimmune serums, were discussed in previous papers.1 It has been shown that Hemophilus pertussis, the etiologic agent of whooping cough, is sensitive to streptomycin in concentrations of from 1 to 3 micrograms in a cubic centimeter of medium and, therefore, the antibiotic substance might have some therapeutic value. Bradford and Day2 showed that streptomycin favorably altered the course of murine pertussis. The present report deals with the observations on the effect of streptomycin in children ill with whooping cough treated at the Willard Parker Hospital. MATERIAL AND PROCEDURES Streptomycin was administered to 129 patients over a six month period, from April 1 through Sept. 30, 1947. One hundred of these were under 1 year of age. There were an additional 21 children under 1 year who received no streptomycin (table 1). The patients
American journal of diseases of children – American Medical Association
Published: Aug 1, 1949
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