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STREPTOMYCIN IN TREATMENT OF WHOOPING COUGH

STREPTOMYCIN IN TREATMENT OF WHOOPING COUGH THE ESSENTIAL procedures in the treatment of whooping cough, which included the use of human hyperimmune serums, were discussed in previous papers.1 It has been shown that Hemophilus pertussis, the etiologic agent of whooping cough, is sensitive to streptomycin in concentrations of from 1 to 3 micrograms in a cubic centimeter of medium and, therefore, the antibiotic substance might have some therapeutic value. Bradford and Day2 showed that streptomycin favorably altered the course of murine pertussis. The present report deals with the observations on the effect of streptomycin in children ill with whooping cough treated at the Willard Parker Hospital. MATERIAL AND PROCEDURES Streptomycin was administered to 129 patients over a six month period, from April 1 through Sept. 30, 1947. One hundred of these were under 1 year of age. There were an additional 21 children under 1 year who received no streptomycin (table 1). The patients http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1949.02030050212004
Publisher site
See Article on Publisher Site

Abstract

THE ESSENTIAL procedures in the treatment of whooping cough, which included the use of human hyperimmune serums, were discussed in previous papers.1 It has been shown that Hemophilus pertussis, the etiologic agent of whooping cough, is sensitive to streptomycin in concentrations of from 1 to 3 micrograms in a cubic centimeter of medium and, therefore, the antibiotic substance might have some therapeutic value. Bradford and Day2 showed that streptomycin favorably altered the course of murine pertussis. The present report deals with the observations on the effect of streptomycin in children ill with whooping cough treated at the Willard Parker Hospital. MATERIAL AND PROCEDURES Streptomycin was administered to 129 patients over a six month period, from April 1 through Sept. 30, 1947. One hundred of these were under 1 year of age. There were an additional 21 children under 1 year who received no streptomycin (table 1). The patients

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Aug 1, 1949

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