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DIABETES MELLITUS ASSOCIATED WITH MONGOLISM

DIABETES MELLITUS ASSOCIATED WITH MONGOLISM THE COMBINATION of mongolism and diabetes poses an interesting and unusual problem. According to the available reported observations with respect to carbohydrate metabolism in mongolism,1 there occurs a definitely delayed glycemic response in this condition. Such a delayed glycemic response has been repeatedly demonstrated by means of dextrose tolerance tests. These were invariably characterized by low, absent or delayed peaks in the concentration of the blood sugar following the ingestion of the dextrose. With advancing age, these mongolian idiots showed this tendency in increasingly more pronounced form. The onset of diabetes at the age of 2 years being in itself quite uncommon, the combination of this condition with mongolism is a most unusual occurrence and probably acounts for the rarity of reports of such cases in the literature. Lawrence,2 who reported on the only 3 patients we could find on record, was of the opinion that his were the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

DIABETES MELLITUS ASSOCIATED WITH MONGOLISM

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1949.02030040673009
Publisher site
See Article on Publisher Site

Abstract

THE COMBINATION of mongolism and diabetes poses an interesting and unusual problem. According to the available reported observations with respect to carbohydrate metabolism in mongolism,1 there occurs a definitely delayed glycemic response in this condition. Such a delayed glycemic response has been repeatedly demonstrated by means of dextrose tolerance tests. These were invariably characterized by low, absent or delayed peaks in the concentration of the blood sugar following the ingestion of the dextrose. With advancing age, these mongolian idiots showed this tendency in increasingly more pronounced form. The onset of diabetes at the age of 2 years being in itself quite uncommon, the combination of this condition with mongolism is a most unusual occurrence and probably acounts for the rarity of reports of such cases in the literature. Lawrence,2 who reported on the only 3 patients we could find on record, was of the opinion that his were the

Journal

American journal of diseases of childrenAmerican Medical Association

Published: May 1, 1949

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