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STUDIES IN IMMUNITY

STUDIES IN IMMUNITY Both immunity to scarlet fever and immunity to diphtheria as measured by cutaneous reactions vary from time to time. We have observed the frequency with which negative reactions become positive over a period of years in several groups of children. This study constitutes a continuation of our previous reports on factors which affect cutaneous reactions.1 PROCEDURE Our purpose was to examine normal variations of cutaneous reactions, uninfluenced by the immunity which may be produced by disease or by artificial immunization. At intervals of one or two years the entire populations of several orphanages were tested with Dick and with Schick toxins. All of the children who had positive reactions were subsequently given injections of immunizing agents and were therefore no longer included in the study. Children whose original tests gave negative results were retested from year to year, and the spontaneous reversals2 in this series of children are here recorded. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1939.04380010044003
Publisher site
See Article on Publisher Site

Abstract

Both immunity to scarlet fever and immunity to diphtheria as measured by cutaneous reactions vary from time to time. We have observed the frequency with which negative reactions become positive over a period of years in several groups of children. This study constitutes a continuation of our previous reports on factors which affect cutaneous reactions.1 PROCEDURE Our purpose was to examine normal variations of cutaneous reactions, uninfluenced by the immunity which may be produced by disease or by artificial immunization. At intervals of one or two years the entire populations of several orphanages were tested with Dick and with Schick toxins. All of the children who had positive reactions were subsequently given injections of immunizing agents and were therefore no longer included in the study. Children whose original tests gave negative results were retested from year to year, and the spontaneous reversals2 in this series of children are here recorded.

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Oct 1, 1939

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