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ISO-AGGLUTININS IN THE NEW-BORN

ISO-AGGLUTININS IN THE NEW-BORN It was demonstrated by von Decastello and Sturli,1 Happ2 and others that at birth the blood group of the infant is rarely established. Normally, the agglutinogens appear before the iso-agglutinins and by the end of the first year the blood grouping is usually complete. The presence of iso-agglutinins in the blood from the umbilical cord raises the question as to their origin, whether they are a product of the biologic activity of the fetus or whether they have been transmitted from the mother by way of the placenta. If the iso-agglutinins find their source in the maternal circulation, observations as to their fate in the blood of the new-born would prove of interest. This consideration involves not alone the problem of placental permeability but the relationship of iso-agglutinins of the cord blood to the later development of blood groups by the infant. HISTORICAL REVIEW What constitutes the stimulus http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

ISO-AGGLUTININS IN THE NEW-BORN

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1928.01920250061005
Publisher site
See Article on Publisher Site

Abstract

It was demonstrated by von Decastello and Sturli,1 Happ2 and others that at birth the blood group of the infant is rarely established. Normally, the agglutinogens appear before the iso-agglutinins and by the end of the first year the blood grouping is usually complete. The presence of iso-agglutinins in the blood from the umbilical cord raises the question as to their origin, whether they are a product of the biologic activity of the fetus or whether they have been transmitted from the mother by way of the placenta. If the iso-agglutinins find their source in the maternal circulation, observations as to their fate in the blood of the new-born would prove of interest. This consideration involves not alone the problem of placental permeability but the relationship of iso-agglutinins of the cord blood to the later development of blood groups by the infant. HISTORICAL REVIEW What constitutes the stimulus

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jul 1, 1928

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