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J. Harris, Patricia Sharp (1990)
Inner ear autoantibodies in patients with rapidly progressive sensorineural hearing lossThe Laryngoscope, 100
C. Morimoto, Alfred, D. Steinberg, N. Letvin, M. Hagan, Tsutomu Takeuchi, J. Daley, H. Levine, S. Schlossman (1987)
A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.The Journal of clinical investigation, 79 3
Minako Yamamoto, J. Kanzaki, K. Ogawa, S. Ogawa, N. Tsuchihashi (1994)
Evaluation of hearing recovery in patients with sudden deafness.Acta oto-laryngologica. Supplementum, 514
T. Joliat, J. Bernstein, J. Cho, M. Krug, T. Fujiyoshi, J. Seyer, X. Ye, T. Yoo (1992)
Antibodies against a 30 Kilodalton Cochlear Protein and Type II and IX Collagens in the Serum of Patients with Inner Ear DiseasesAnnals of Otology, Rhinology & Laryngology, 101
Taiji H Kanzaki J (1988)
Evaluation of hearing recovery and efficacy of steroid treatment in sudden deafnessActa Otolaryngol Suppl (Stockh), 456
Kobayashi T Ikeda K (1989)
Immunological abnormality of the serological test in bilateral sensorineural hearing lossORL J Otorhinolaryngol Relat Spec, 51
S. Helfgott, Carlos Lorenzo, Raphael Kieval, David Trentham, Ra Mosciscki, J. Martin, Michael McKenna, J. Nadol (1991)
Correlation between antibodies to type II collagen and treatment outcome in bilateral progressive sensorineural hearing lossThe Lancet, 337
J. Kanzaki, H. Taiji, K. Ogawa (1988)
Evaluation of hearing recovery and efficacy of steroid treatment in sudden deafness.Acta oto-laryngologica. Supplementum, 456
R. Cole, R. Jahrsdoerfer (1988)
Sudden hearing loss: an update.The American journal of otology, 9 3
R. Moscicki, E. Martin, C. Quintero, S. Rauch, J. Nadol, K. Bloch (1994)
Serum antibody to inner ear proteins in patients with progressive hearing loss. Correlation with disease activity and response to corticosteroid treatment.JAMA, 272 8
Inove Y Kanzaki J (1994)
Immunological findings of serological tests in steroidresponsive sensorineural hearing lossActa Otolaryngol Suppl (Stockh), 514
Deborah Fowellf†, A. Mcknight, F. Powrie, R. Dyke†, D. Mason (1991)
Subsets of CD4+ T Cells and their Roles in the Induction and Prevention of AutoimmunityImmunological Reviews, 123
G. Hughes, R. Moscicki, B. Barna, J. Martin (1994)
Laboratory diagnosis of immune inner ear disease.The American journal of otology, 15 2
Shinsuke Tanaka, T. Matsuyama, A. Steinberg, S. Schlossman, C. Morimoto (1989)
Antilymphocyte antibodies against CD4+2H4+ cell populations in patients with systemic lupus erythematosus.Arthritis and rheumatism, 32 4
W. Arnold, R. Pfaltz, H. Altermatt (1985)
Evidence of serum antibodies against inner ear tissues in the blood of patients with certain sensorineural hearing disorders.Acta oto-laryngologica, 99 3-4
B. Mccabe (1979)
Autoimmune Sensorineural Hearing LossAnnals of Otology, Rhinology & Laryngology, 88
A. Cohn, J. Sataloff, J. Lindsay (1970)
Histiocytosis X (Letterer-Siwe Disease) With Involvement of the Inner EarArchives of Otolaryngology-head & Neck Surgery, 91
D. Mayot, M. Béné, K. Dron, C. Perrin, G. Faure (1993)
Immunologic alterations in patients with sensorineural hearing disorders.Clinical immunology and immunopathology, 68 1
G. Hughes, S. Kinney, B. Barna, L. Calabrese (1983)
Autoimmune Reactivity in Meniere'S Disease: A Preliminary ReportThe Laryngoscope, 93
T. Yoon, M. Paparella, P. Schachern (1989)
Systemic vasculitis: A temporal bone histopathologic studyThe Laryngoscope, 99
G. Hughes, S. Kinney, B. Barna, R. Tomsak, L. Calabrese (1983)
Autoimmune reactivity in Cogan's syndrome: A preliminary reportOtolaryngology–Head and Neck Surgery, 91
Barna BP Hughes GB (1983)
Autoimmune reactivity in Cogan's syndrome: a preliminary reportArch Otolaryngol Head Neck Surg, 91
Hanada T Veldman JE (1993)
Diagnostic and therapeutic dilemmas in rapidly progressive sensorineural hearing loss and sudden deafnessActa Otolaryngol (Stockh), 113
San Martín JE Mosciscki RA (1994)
Serum antibody to inner ear proteins in patients with progressive hearing lossJAMA, 272
Kanzaki J Yamamoto M (1994)
Evaluation of hearing recovery in patients with sudden deafnessActa Otolaryngol Suppl (Stockh), 514
J. Rowe-Jones, D. Macallan, M. Sorooshian (1990)
Polyarteritis nodosa presenting as bilateral sudden onset cochleo-vestibular failure in a young womanThe Journal of Laryngology & Otology, 104
D. Plester, Soliman Am (1989)
Autoimmune hearing loss.The American journal of otology, 10 3
A. Kahan, K. Hamzaoui, K. Ayed (1992)
Abnormalities of T lymphocyte subsets in Behçet's disease demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies.The Journal of rheumatology, 19 5
W. Wilson, F. Byl, N. Laird (1980)
The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study.Archives of otolaryngology, 106 12
Harris JP Yamanobe S (1993)
Inner specific autoantibodiesLaryngoscope, 103
H. Schuknecht, J. Nadol (1994)
Temporal bone pathology in a case of cogan's syndromeThe Laryngoscope, 104
J. Veldman, T. Hanada, F. Meeuwsen (1993)
Diagnostic and therapeutic dilemmas in rapidly progressive sensorineural hearing loss and sudden deafness. A reappraisal of immune reactivity in inner ear disorders.Acta oto-laryngologica, 113 3
S. Yamanobe, J. Harris (1993)
Inner ear‐specific autoantibodiesThe Laryngoscope, 103
Alice Kahan, André Kahan, Franqoise Picard, Charles-Joël Menkes, Bernard Amor (1991)
Abnormalities of T lymphocyte subsets in systemic sclerosis demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies.Annals of the Rheumatic Diseases, 50
Byl FM Wilson RB (1980)
The efficacy of steroids in the treatment of idiopathic sudden hearing lossArch Otolaryngol Head Neck Surg, 106
Abstract Background: Although there are a number of reports concerned with the role of immunity in the sudden onset of progressive sensorineural hearing loss, there are few references dealing with the involvement of immunemediated mechanisms in sudden deafness. Objective: To study the phenotype of peripheral blood lymphocytes in a group of patients with sudden deafness by use of 3-color flow cytometry. Design: The study was carried out prior to the start of steroid therapy. Fourteen patients underwent a follow-up study once steroid therapy had been completed. Prospective analysis, case-control. Setting: Tertiary case referral center, ambulatory and hospitalized care. Patients: Twenty-two patients (13 men and 9 women; mean age, 45.3 years) were compared with 14 healthy control subjects (9 men and 5 women; mean age, 36 years). Patients were divided in 2 groups according to their response to steroid therapy. Results: Decreased numbers of both CD4+ helper cells (38.4% vs 45.5%; P=.04) and CD8+ cytotoxic cells (17.5% vs 22.3%; P=.02) were observed in patients and compared with those in the control subjects, as well as reduced numbers of CD4+CD45RA+ cells (14.4% vs 29.3%; P=.01) and CD8+CD45RA+ naive cells (18.2% vs 25.4%; P=.04). In the group of patients with a good response to steroid therapy (group 1), a tendency toward normalization of the CD4+ (pretreatment, 38.6%; posttreatment, 44.6%), CD4+CD45RA+ (pretreatment, 15.2%; posttreatment, 21.7%), and CD4+CD45RO+ (pretreatment, 21.1%; posttreatment, 18.2%) cell counts was observed, with a slight decrease in the CD8+ population (pretreatment, 18%; posttreatment, 15.7%). However, in patients with a poorer response (group 2), while there were increases in the CD4+ (pretreatment, 38%; posttreatment, 50%) and CD4+CD45RA+ (pretreatment, 12.8%; posttreatment, 16.7%) cell counts after steroid therapy, there was a significant increment in the CD4+CD45RO+ memory cell count (pretreatment, 14,1%; posttreatment, 28.5%) and low CD8+CD45RA+ counts (pretreatment, 14.6%; posttreatment, 15.5%). No differences were observed in the numbers of B or natural killer cells or in the presence of activation antigens CD25 and HLA-DR when pretreatment and posttreatment levels were compared. Conclusion: These results demonstrate significant abnormalities in the subpopulations of lymphocytes in patients with sudden hearing loss, suggesting the existence of immune-mediated responses in the inner ear as possible etiopathogenic factors in this entity.Arch Otolaryngol Head Neck Surg. 1997;123:712-717 References 1. Wilson RB, Byl FM, Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss . Arch Otolaryngol Head Neck Surg . 1980;106:772-776.Crossref 2. McCabe BF. Autoimmune sensorineural hearing loss . Ann Otol Rhinol Laryngol . 1979;88:585-589. 3. Yoon TH, Paparella MM. Systemic vasculitis: a temporal bone histopathologic study . Laryngoscope . 1989;99:600-609.Crossref 4. Rowe-Jones JM, Macallan DC, Sorooshian M. Polyarteritis nodosa presenting as bilateral sudden onset cochleo-vestibular failure in a young woman . J Laryngol Otol . 1990;104:562-564.Crossref 5. Schuknecht HF, Nadol JB. Temporal bone pathology in a case of Cogan's syndrome . Laryngoscope . 1994;104:1135-1142.Crossref 6. Hughes GB, Barna BP, Tomsak RL, Calabrese LH. Autoimmune reactivity in Cogan's syndrome: a preliminary report . Arch Otolaryngol Head Neck Surg . 1983; 91:24-32. 7. Cole RR, Jahrsdoerfer RA. Sudden hearing loss: an update . Am J Otol . 1988;9: 211-215. 8. Hughes GB, Kinney SE, Barna BP, Calabrese LH. Autoimmune reactivity in Meniere's disease: a preliminary report . Laryngoscope . 1983;93:410-417. 9. Hughes GB, Mosciscki R, Barna BP, San Martin JE. Laboratory diagnosis of immune inner ear disease . Am J Otol . 1994;15:198-202. 10. Mayot DM, Bene MC, Dron K, Perrin C, Faure GC. Immunological alterations in patients with sensorineural hearing disorders . Clin Immunol Immunopathol . 1993; 68:41-45.Crossref 11. Arnold W, Pfaltz R, Altermatt HJ. Evidence of serum antibodies against inner ear tissues in the blood of patients with certain sensorineural hearing disorders . Acta Otolaryngol (Stockh) . 1985;99:437-444.Crossref 12. Plester D, Soliman AM. Autoimmune hearing loss . Am J Otol . 1989;10:188-192.Crossref 13. Veldman JE, Hanada T, Meeuwsen F. Diagnostic and therapeutic dilemmas in rapidly progressive sensorineural hearing loss and sudden deafness . Acta Otolaryngol (Stockh) . 1993;113:303-306.Crossref 14. Harris JP, Sharp PA. Inner ear autoantibodies in patients with rapidly progressive sensorineural hearing loss . Laryngoscope . 1990;100:516-524.Crossref 15. Yamanobe S, Harris JP. Inner specific autoantibodies . Laryngoscope . 1993;103: 319-325.Crossref 16. Joliat T, Seyer J, Bernstein J, et al. Antibodies against a 30 kilodalton cochlear protein and type II and IX collagens in the serum of patients with inner ear diseases . Ann Otol Rhinol Laryngol . 1992;101:1000-1006. 17. Mosciscki RA, San Martín JE, Quintero CH, Rauch R, Nadol JB, Bloch KJ. Serum antibody to inner ear proteins in patients with progressive hearing loss . JAMA . 1994;272:611-616.Crossref 18. Kanzaki J, Taiji H, Ogawa K. Evaluation of hearing recovery and efficacy of steroid treatment in sudden deafness . Acta Otolaryngol Suppl (Stockh) . 1988;456: 31-36.Crossref 19. Yamamoto M, Kanzaki J, Ogawa K, Ogawa S, Tsuchihashi N. Evaluation of hearing recovery in patients with sudden deafness . Acta Otolaryngol Suppl (Stockh) . 1994;514:37-40.Crossref 20. Ikeda K, Kobayashi T, Itoh Z, Suzuki H, Kusakari J, Takasaka T. Immunological abnormality of the serological test in bilateral sensorineural hearing loss . ORL J Otorhinolaryngol Relat Spec . 1989;51:268-275.Crossref 21. Kanzaki J, Inove Y, Ouchi T. Immunological findings of serological tests in steroidresponsive sensorineural hearing loss . Acta Otolaryngol Suppl (Stockh) . 1994; 514:66-69.Crossref 22. Helfgott SM, Mosciscki RA, San Martín J, et al. Correlation between antibodies to type II collagen and treatment outcome in bilateral progressive sensorineural hearing loss . Lancet . 1991;337:387-389.Crossref 23. Fowell D, McKnight AJ, Powrie F, et al. Subset of CD4+ T cells and their roles in the induction and prevention of autoimmunity . Immunol Rev . 1991;123:37-64.Crossref 24. Morimoto C, Steinberg AD, Letvin NL, et al. A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody . J Clin Invest . 1987;79:762-768.Crossref 25. Kahan L, Hamzoui K, Ayed K. Abnormalities of T lymphocyte subsets in Behçet's disease demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies . J Rheumatol . 1992;19:742-746. 26. Tanaka S, Matsuyama T, Steinberg AD, Schossman SF, Morimoto C. Antilymphocyte antibodies against CD4+2H+ cell population in patients with systemic lupus erythematosus . Arthritis Rheum . 1989;32:398-405.Crossref 27. Kahan A, Kahan A, Picard F, Menkes CJ, Amor B. Abnormalities of T lymphocyte subsets in systemic sclerosis demonstrated with anti-CD45RA and anti-CD29 monoclonal antibodies . Ann Rheum Dis . 1991;50:354-358.Crossref
Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Jul 1, 1997
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