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Fluticasone

Fluticasone Abstract I have been successfully using fluticasone propionate for some years in my patients with sinusitis, both before and after nasal surgery, including endoscopic polypectomy. It was therefore with some anxiety that I read the startling title of the article by Mostafa in the Archives.1 This changed to bewilderment when I read the contents. The patients were selected preoperatively and non-consecutively. What of those not selected? How were asthma (often undiagnosed in these patients) and mucociliary clearance abnormalities (almost universal in these patients) excluded? The randomization method described, including several levels of matching, is obscure and improbable. The study is not blinded for either the patients, who were told that there was something different about fluticasone, or the operating surgeon, who was presumably the author. The biggest flaw, however, is that randomization was performed preoperatively. The population given the nasal spray would have a completely different profile on computed tomography, References 1. Mostafa BE. Fluticasone propionate is associated with severe infection after endoscopic polypectomy . Arch Otolaryngol Head Neck Surg. . 1996;122:729-731.Crossref 2. Birchall MA, Studham JM, Henderson JC, Phillips IS, Pride NB, Fuller RW. The effects of a single dose and a four-week course of fluticasone propionate on intranasal histamine challenge in allergic rhinitis . Clin Otolaryngol. 1995; 20:204-210.Crossref 3. Thomas DM, Stafford ND, Richards D, Birchall MA. Fluticasone propionate in the treatment of HIV-related rhinosinusitis. Presented at the 16th Congress of the European Rhinologic Society; September 15, 1996; Ghent, Belgium. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Fluticasone

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1997.01900040101017
Publisher site
See Article on Publisher Site

Abstract

Abstract I have been successfully using fluticasone propionate for some years in my patients with sinusitis, both before and after nasal surgery, including endoscopic polypectomy. It was therefore with some anxiety that I read the startling title of the article by Mostafa in the Archives.1 This changed to bewilderment when I read the contents. The patients were selected preoperatively and non-consecutively. What of those not selected? How were asthma (often undiagnosed in these patients) and mucociliary clearance abnormalities (almost universal in these patients) excluded? The randomization method described, including several levels of matching, is obscure and improbable. The study is not blinded for either the patients, who were told that there was something different about fluticasone, or the operating surgeon, who was presumably the author. The biggest flaw, however, is that randomization was performed preoperatively. The population given the nasal spray would have a completely different profile on computed tomography, References 1. Mostafa BE. Fluticasone propionate is associated with severe infection after endoscopic polypectomy . Arch Otolaryngol Head Neck Surg. . 1996;122:729-731.Crossref 2. Birchall MA, Studham JM, Henderson JC, Phillips IS, Pride NB, Fuller RW. The effects of a single dose and a four-week course of fluticasone propionate on intranasal histamine challenge in allergic rhinitis . Clin Otolaryngol. 1995; 20:204-210.Crossref 3. Thomas DM, Stafford ND, Richards D, Birchall MA. Fluticasone propionate in the treatment of HIV-related rhinosinusitis. Presented at the 16th Congress of the European Rhinologic Society; September 15, 1996; Ghent, Belgium.

Journal

Archives of Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Apr 1, 1997

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