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F. Martínez-Madrigal, C. Micheau (1989)
Histology of the major salivary glands.The American journal of surgical pathology, 13 10
N. Douarin, J. Smith (1988)
Development of the peripheral nervous system from the neural crest.Annual review of cell biology, 4
I. Dardick (1995)
Myoepithelioma: definitions and diagnostic criteria.Ultrastructural pathology, 19 5
Allen-Hoffman B Sabatini L (1991)
Serial cultivation of epithelial cells from human salivary glandsIn Vitro Cell Dev Biol Anim, 27
H. Iga, M. Azuma, S. Nagamine, R. Kaji, M. Takase, T. Yanagawa, H. Yoshida, M. Sato (1989)
Expression of neurofilaments in a neoplastic human salivary intercalated duct cell line or its derivatives and effect of nerve growth factor on the cellular proliferation and phenotype.Cancer research, 49 23
E. Durban, P. Barreto, J. Hilgers, A. Sonnenberg (1994)
Cell phenotypes and differentiative transitions in mouse submandibular salivary gland defined with monoclonal antibodies to mammary epithelial cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 42
C. Gans, R. Northcutt (1983)
Neural Crest and the Origin of Vertebrates: A New HeadScience, 220
M. Selleck, M. Bronner‐Fraser (1995)
Origins of the avian neural crest: the role of neural plate-epidermal interactions.Development, 121 2
D. Stemple, D. Anderson (1992)
Isolation of a stem cell for neurons and glia from the mammalian neural crestCell, 71
Rossiev Da, Huaman Ja, Barsky Sh (1992)
A study of the heterogeneity of the mucoepidermoid tumor and the implication for future therapies.Archives of Otolaryngology-head & Neck Surgery, 118
B. Kurth, D. Hazen‐Martin, M. Sens, R. Dechamplain, D. Sens (1989)
Cell culture and characterization of human minor salivary gland duct cells.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 18 4
G. Couly, P. Coltey, N. Douarin (1992)
The developmental fate of the cephalic mesoderm in quail-chick chimeras.Development, 114 1
M. Selleck, T. Scherson, M. Bronner‐Fraser (1993)
Origins of neural crest cell diversity.Developmental biology, 159 1
A. Baroffio, E. Dupin, N. Douarin (1991)
Common precursors for neural and mesectodermal derivatives in the cephalic neural crest.Development, 112 1
T. Hirano, J. Gluckman, E. Devries (1990)
The Expression of a Vascular Smooth-Muscle Actin in Salivary Gland TumorsArchives of Otolaryngology-head & Neck Surgery, 116
K. Keyomarsi, L. Sandoval, V. Band, A. Pardee (1991)
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.Cancer research, 51 13
D. Sens, D. Hintz, M. Rudisill, M. Sens, S. Spicer (1985)
Explant culture of human submandibular gland epithelial cells: evidence for ductal origin.Laboratory investigation; a journal of technical methods and pathology, 52 5
M. Bronner‐Fraser (1993)
Mechanisms of neural crest cell migrationBioEssays, 15
J. Batsakis, J. Regezi, M. Luna, A. El-Naggar (1989)
Histogenesis of salivary gland neoplasms: a postulate with prognostic implicationsThe Journal of Laryngology & Otology, 103
Johns Me, Goldsmith Mm (1989)
Incidence, diagnosis, and classification of salivary gland tumors. Part 1.Oncology, 3
I. Dardick, R. Byard, J. Carnegie (1990)
A review of the proliferative capacity of major salivary glands and the relationship to current concepts of neoplasia in salivary glands.Oral surgery, oral medicine, and oral pathology, 69 1
P. Trainor, S. Tan, P. Tam (1994)
Cranial paraxial mesoderm: regionalisation of cell fate and impact on craniofacial development in mouse embryos.Development, 120 9
D. Witsell, M. Weissler, E. Livanos, C. Bova-Hill, T. Gilmer (1993)
Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain.Archives of otolaryngology--head & neck surgery, 119 10
F. Chiu, E. Barnes, K. Das, J. Haley, P. Socolow, F. Macaluso, J. Fant (1989)
Characterization of a novel 66 kd subunit of mammalian neurofilamentsNeuron, 2
He X Marmary Y (1989)
Beta-adrenergic responsiveness in a human submandibular tumor cell lineIn Vitro Cell Dev Biol Anim, 25
Cepko C (1989)
Lineage analysis in the vertebrate nervous system by retrovirusmediated gene transferMethods Neurosci, 1
Byard RW Burford-Mason A (1991)
The pathobiology of the salivary gland, I: growth and development of rat submandibular gland organoids cultured in a collagen gel matrixVirchows Arch, 418
Peter Hall, Fiona Watt (1989)
Stem cells: the generation and maintenance of cellular diversity.Development, 106 4
T. Tohyama, V. Lee, L. Rorke, M. Marvin, R. McKay, J. Trojanowski (1992)
Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells.Laboratory investigation; a journal of technical methods and pathology, 66 3
M. Bronner‐Fraser (1994)
Neural crest cell formation and migration in the developing embryoThe FASEB Journal, 8
H. Yoshida, M. Azuma, Tetsuo Yanagawa, Y. Yura, Y. Hayashi, Mitsunobu Sato (1986)
Effect of dibutyryl cyclic AMP on morphologic features and biologic markers of a human salivary gland adenocarcinoma cell line in cultureCancer, 57
Abstract Objective: To determine whether a heterogeneous collection of salivary gland tumors shared common antigenic characteristics and growth patterns in tissue culture. Design: Cell cultures were derived from benign and malignant salivary gland neoplasms, cultured conservatively, and serially analyzed for epithelial, myoepithelial, and neuroectodermal antigens. Subjects: Nineteen samples reflecting the spectrum of salivary tumor pathologic characteristics were established in tissue culture. Most were derived from benign pleomorphic adenomas, and several were from carcinomas, including carcinoma ex pleomorphic adenoma, and mucoepidermoid and adenoid cystic carcinoma. Results: All cultures were epithelial as determined by morphologic and antigenic examination, using antibodies for cytokeratin. The phenotype of cells derived from benign tumors, especially the pleomorphic adenomas, resembled those in the original neoplasm. Those from carcinomas were similar, with less differentiated characteristics. Manipulation of growth conditions altered the phenotypes shown in culture. Some cultures contained cells expressing vascular smooth-muscle actin and glial fibrillary acidic protein or nestin. Conclusions: This model cell system containing proliferative cells from several tumor types is consistent with a stem-cell theory of salivary gland tumor origin. Our data were not consistent with the bicellular or multicellular theory. We hypothesize a neuroectodermal origin for this group of apparently heterogeneous tumors. These cultured cells will be valuable for in-depth investigation of the loss of proliferation controls in benign and malignant tumors of the salivary gland.(Arch Otolaryngol Head Neck Surg. 1996;122:551-558) References 1. Martinez-Madrigal F, Micheau C. Histology for the major salivary glands . Am J Surg Pathol . 1989;13:879-899.Crossref 2. Johns M, Goldsmith M. Incidence, diagnosis, and classification of salivary gland tumors, 1 . Oncology . 1989;3:47-56. 3. Yoshida H, Azuma M, Yanagawa T, Yura Y, Sato M. Effect of dibutyl cyclic AMP on morphologic features and biologic markers of a human salivary gland adenocarcinoma cell line in culture . Cancer . 1986;57:1011-1018.Crossref 4. Dardick I, Byard R, Carnegie J. A review of the proliferative capacity of major salivary glands and the relationship to current concepts of neoplasia in salivary glands . Oral Surg Oral Med Oral Pathol . 1990;69:53-67.Crossref 5. Burford-Mason A, Byard RW, Dardick I, van Nostrand AWP. The pathobiology of the salivary gland, I: growth and development of rat submandibular gland organoids cultured in a collagen gel matrix . Virchows Arch . 1991;418: 387-400.Crossref 6. Batsakis J, Regezi J, Luna M, el-Naggar A. Histogenesis of salivary gland neoplasms: a postulate with prognostic implications . J Laryngol Otol . 1989;103: 939-944.Crossref 7. Witsell D, Weissler M, Livanos E, Bova-Hill C, Gilmer T. Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain . Arch Otolaryngol Head Neck Surg . 1993;119:1151-1157.Crossref 8. Sabatini L, Allen-Hoffman B, Warner T, Azen E. Serial cultivation of epithelial cells from human salivary glands . In Vitro Cell Dev Biol Anim . 1991;27:939-948.Crossref 9. Marmary Y, He X, Hand A, Ship J, Wellner R. Beta-adrenergic responsiveness in a human submandibular tumor cell line . In Vitro Cell Dev Biol Anim . 1989; 25:951-958.Crossref 10. Ross DA, Huaman JA, Barsky SH. A study of the heterogeneity of the mucoepidermoid tumor and the implication for future therapies . Arch Otolaryngol Head Neck Surg . 1992;118:1172-1178.Crossref 11. Sens DA, Hintz DS, Rudisill MT, Sens MA, Spicer SS. Explant culture of the human submandibular gland epithelial cells: evidence for ductal origin . Lab Invest . 1985;52:559-567. 12. Kurth BE, Hazen-Martin DJ, Sens MA, DeChamplain RW, Sens DA. Cell culture and characterization of human minor salivary gland duct cells . J Oral Pathol Med . 1989;18:214-219.Crossref 13. Iga H, Azuma M, Nagamine S, et al. Expression of neurofilaments in a neoplastic human salivary intercalated duct cell line or its derivatives and effect of nerve growth factor on the cellular proliferation and phenotype . Cancer . 1989; 49:6708-6719. 14. Keyomarski K, Sandoval L, Band V, Pardee AB. Synchronization of tumor and normal cells from GI to multiple cell cycles by lovastatin . Cancer Res . 1991; 51:3602-3609. 15. Tohyama T, Lee VMY, Rorke LB, Marvin M, McKay RDG, Trojanowski JQ. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells . Lab Invest . 1992;66:303-313. 16. Chiu F-C, Barnes EA, Das K, et al. Characterization of a novel 66 kd subunit of mammalian neurofilaments . Neuron . 1989;2:1435-1445.Crossref 17. Hirano T, Gluckman J, de Vries E. 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Annu Rev Cell Biol . 1988;4:375-404.Crossref 24. Bronner-Fraser M. Mechanisms of neural crest cell migration . Bioessays . 1993; 15:221-230.Crossref 25. Bronner-Fraser M. Neural crest cell formation and migration in the developing embryo . FASEB J . 1994;8:699-706. 26. Selleck MAJ, Scherson TY, Bronner-Fraser M. Dev Biol . 1993;159:1-11.Crossref 27. Gans C, Northcutt RG. Neural crest and the origin of vertebrates: a new head . Science . 1983;220:268-274.Crossref 28. Sellect MAJ, Bronner-Fraser M. Origins of the avian neural crest: the role of neural palate-epidermal interactions . Development . 1995;121:525-538. 29. Baroffio A, Dupin E, LeDouarin NM. Common precursors for neural or mesectodermal derivatives in the cephalic neural crest . Development . 1991;112: 301-305. 30. Trainor PA, Tan S-S, Tam PPL. Cranial paraxial mesoderm: regionalization of cell fate and impact on craniofacial development in mouse embryos . Development . 1994;120:2397-2408. 31. 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Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: May 1, 1996
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