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Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival

Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival Abstract Objective: To determine the relationship between human papillomavirus (HPV) DNA detection in upper aerodigestive tract malignancies and patient outcome. Design: Archival paraffin-embedded specimens from 78 previously untreated patients with squamous carcinomas of the larynx and hypopharynx were pathologically verified and analyzed by polymerase chain reaction for detection of HPV DNA. Charts were independently reviewed and coded until final analysis. Setting: The University of Texas M. D. Anderson Cancer Center, Houston, a tertiary cancer referral center. Results: DNA was successfully extracted from 65 archival patient samples (83%). The mean (±SEM) duration of follow-up for these patients was 42±21 months. Thirty specimens (46%) exhibited detectable HPV DNA. Detection of HPV was significantly related to decreased survival, independent of disease stage. Log rank testing revealed that HPV detection, pathologic vascular invasion, and nodal status were the most significant predictors of death of disease. Conclusions: Laryngeal and hypopharyngeal carcinomas with detectable HPV may represent a biologically distinct subset of tumors that carry a poorer prognosis than do cancers with no detectable HPV.(Arch Otolaryngol Head Neck Surg. 1994;120:743-748) References 1. Zur Hausen H, Schneider A. The role of papillomaviruses in anogenital cancer . In: Salzman NP, Howley PM, eds. The Papillomaviruses . New York, NY: Plenum Publishing Corp; 1987:245-263. 2. Zur Hausen H. Intracellular surveillance of persisting viral infections: human genital cancer results from deficient cellular control of papillomavirus gene expression . Lancet . 1986;2:489-491.Crossref 3. Zur Hausen H. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers . Cancer Res . 1989;49:4677-4681. 4. Loning T, Ikenberg H, Becker J, et al. Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type–related DNA . J Invest Dermatol . 1985;84:417-420.Crossref 5. Brandsma JL, Steinberg BM, Abramson AL, Winkler B. Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx . Cancer Res . 1986;46:2185-2188. 6. Brandsma JL, Abramson AL. Association of papillomavirus with cancers of the hand and neck . Arch Otolaryngol Head Neck Surg . 1989;115:621-625.Crossref 7. Lindberg H, Fey SJ, Ottosen PD, Mose Larsen P. Human papillomavirus (HPV) and carcinomas of the head and neck . Clin Otolaryngol . 1988;13:447-454.Crossref 8. Ogura H, Watanabe S, Fukushima K, et al. Presence of human papillomavirus type 18 DNA in pharyngeal and laryngeal carcinoma . Jpn J Cancer Res . 1991; 82:1184-1186.Crossref 9. Manos M, Ting Y, Wright DK, et al. The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses . Cancer Cells . 1989;7:209-214. 10. Heller MJ, Burgart LJ, TenEyck CJ, et al. An efficient method for the extraction of DNA from formalin-fixed, paraffin-embedded tissue by sonication . Biotechniques . 1991;11:372-377. 11. Peto R, Peto J. Asymptotically efficient rank invariant procedures . J R Stat Soc . 1972;135:185-207. Series A. 12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457-581.Crossref 13. Dyson N, Howley PM, Munger K, Harlow E. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product . Science . 1989; 243:934-937.Crossref 14. Munger K, Werness BA, Dyson N, Phelps WC, Howley PM. Complex formation of human papillomavirus E7 proteins with retinoblastoma tumor suppressor gene product . EMBO J . 1989;8:4099-4105. 15. Scheffner M, Munger K, Byrne JC, Howley PM. The stage of the p53 and retinoblastoma genes in human cervical carcinoma cell lines . Proc Natl Acad Sci U S A . 1991;88:5523-5527.Crossref 16. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 . Cell . 1990;63:1129-1136.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Human Papillomavirus in Laryngeal and Hypopharyngeal Carcinomas: Relationship to Survival

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1994.01880310047009
Publisher site
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Abstract

Abstract Objective: To determine the relationship between human papillomavirus (HPV) DNA detection in upper aerodigestive tract malignancies and patient outcome. Design: Archival paraffin-embedded specimens from 78 previously untreated patients with squamous carcinomas of the larynx and hypopharynx were pathologically verified and analyzed by polymerase chain reaction for detection of HPV DNA. Charts were independently reviewed and coded until final analysis. Setting: The University of Texas M. D. Anderson Cancer Center, Houston, a tertiary cancer referral center. Results: DNA was successfully extracted from 65 archival patient samples (83%). The mean (±SEM) duration of follow-up for these patients was 42±21 months. Thirty specimens (46%) exhibited detectable HPV DNA. Detection of HPV was significantly related to decreased survival, independent of disease stage. Log rank testing revealed that HPV detection, pathologic vascular invasion, and nodal status were the most significant predictors of death of disease. Conclusions: Laryngeal and hypopharyngeal carcinomas with detectable HPV may represent a biologically distinct subset of tumors that carry a poorer prognosis than do cancers with no detectable HPV.(Arch Otolaryngol Head Neck Surg. 1994;120:743-748) References 1. Zur Hausen H, Schneider A. The role of papillomaviruses in anogenital cancer . In: Salzman NP, Howley PM, eds. The Papillomaviruses . New York, NY: Plenum Publishing Corp; 1987:245-263. 2. Zur Hausen H. Intracellular surveillance of persisting viral infections: human genital cancer results from deficient cellular control of papillomavirus gene expression . Lancet . 1986;2:489-491.Crossref 3. Zur Hausen H. Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers . Cancer Res . 1989;49:4677-4681. 4. Loning T, Ikenberg H, Becker J, et al. Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type–related DNA . J Invest Dermatol . 1985;84:417-420.Crossref 5. Brandsma JL, Steinberg BM, Abramson AL, Winkler B. Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx . Cancer Res . 1986;46:2185-2188. 6. Brandsma JL, Abramson AL. Association of papillomavirus with cancers of the hand and neck . Arch Otolaryngol Head Neck Surg . 1989;115:621-625.Crossref 7. Lindberg H, Fey SJ, Ottosen PD, Mose Larsen P. Human papillomavirus (HPV) and carcinomas of the head and neck . Clin Otolaryngol . 1988;13:447-454.Crossref 8. Ogura H, Watanabe S, Fukushima K, et al. Presence of human papillomavirus type 18 DNA in pharyngeal and laryngeal carcinoma . Jpn J Cancer Res . 1991; 82:1184-1186.Crossref 9. Manos M, Ting Y, Wright DK, et al. The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses . Cancer Cells . 1989;7:209-214. 10. Heller MJ, Burgart LJ, TenEyck CJ, et al. An efficient method for the extraction of DNA from formalin-fixed, paraffin-embedded tissue by sonication . Biotechniques . 1991;11:372-377. 11. Peto R, Peto J. Asymptotically efficient rank invariant procedures . J R Stat Soc . 1972;135:185-207. Series A. 12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations . J Am Stat Assoc . 1958;53:457-581.Crossref 13. Dyson N, Howley PM, Munger K, Harlow E. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product . Science . 1989; 243:934-937.Crossref 14. Munger K, Werness BA, Dyson N, Phelps WC, Howley PM. Complex formation of human papillomavirus E7 proteins with retinoblastoma tumor suppressor gene product . EMBO J . 1989;8:4099-4105. 15. Scheffner M, Munger K, Byrne JC, Howley PM. The stage of the p53 and retinoblastoma genes in human cervical carcinoma cell lines . Proc Natl Acad Sci U S A . 1991;88:5523-5527.Crossref 16. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 . Cell . 1990;63:1129-1136.Crossref

Journal

Archives of Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Jul 1, 1994

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