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Increasing Evidence That the Myoepithelial Cell Is the Actual Ancestor of Pleomorphic Adenoma of the Salivary Gland

Increasing Evidence That the Myoepithelial Cell Is the Actual Ancestor of Pleomorphic Adenoma of... Abstract We read the article by Witsell and coworkers1 that appeared in the October issue of the Archives with great interest. In that article the authors describe the establishment of a new cell strain, named UNC4, from a human benign pleomorphic adenoma, and describe its immunocytochemical and cytogenetic features that are consistent with the myoepithelial nature of the cells. These features closely parallel our previously reported findings on a similar myoepithelial cell line, named PA 16/23, that arose from a human pleomorphic adenoma,2 and are in keeping with the studies by Shirasuna and coworkers,3 who first isolated a myoepithelial cell line from a pleomorphic adenoma. Taken together, the bulk of the in vitro studies strongly favor the idea that transformed myoepithelial cells are actual ancestors to pleomorphic adenomas. It seems feasible that the unique histopathologic features of pleomorphic adenomas, in which stromal and epithelial areas coexist, thus justifying References 1. Witsell DL, Weisler MC, Livanos E, Bova-Hill C, Gilmer TM. Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain . Arch Otolaryngol Head Neck Surg . 1993;119:1151-1157.Crossref 2. Gallo O, Bani D, Toccafondi G, Almerigogna F, Fini-Storchi O. Characterization of novel cell line from pleomorphic adenoma of the parotid gland with myoepithelial phenotype and producing interleukin 6 as an autocrine growth factor . Cancer . 1992;70:559-568.Crossref 3. Shirasuna K, Sato M, Miyazaki T. A myoepithelial cell line established from a human pleomorphic adenoma arising in minor salivary gland . Cancer . 1980; 45:297-305.Crossref 4. Shah JP, Ihde JK. Salivary gland tumors . Curr Probl Surg . 1990;27:775-843.Crossref 5. Gallo O, Bani D, Giudizi MG, et al. Spontaneous in vitro differentiation of a myoepithelial cell line (PA 16/23) from a pleomorphic adenoma of the parotid gland is associated with reduced production of the autocrine growth factor interleukin-6. BrJ Cancer. In press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Increasing Evidence That the Myoepithelial Cell Is the Actual Ancestor of Pleomorphic Adenoma of the Salivary Gland

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Increasing Evidence That the Myoepithelial Cell Is the Actual Ancestor of Pleomorphic Adenoma of the Salivary Gland

Abstract

Abstract We read the article by Witsell and coworkers1 that appeared in the October issue of the Archives with great interest. In that article the authors describe the establishment of a new cell strain, named UNC4, from a human benign pleomorphic adenoma, and describe its immunocytochemical and cytogenetic features that are consistent with the myoepithelial nature of the cells. These features closely parallel our previously reported findings on a similar myoepithelial cell line, named PA...
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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1994.01880300089017
Publisher site
See Article on Publisher Site

Abstract

Abstract We read the article by Witsell and coworkers1 that appeared in the October issue of the Archives with great interest. In that article the authors describe the establishment of a new cell strain, named UNC4, from a human benign pleomorphic adenoma, and describe its immunocytochemical and cytogenetic features that are consistent with the myoepithelial nature of the cells. These features closely parallel our previously reported findings on a similar myoepithelial cell line, named PA 16/23, that arose from a human pleomorphic adenoma,2 and are in keeping with the studies by Shirasuna and coworkers,3 who first isolated a myoepithelial cell line from a pleomorphic adenoma. Taken together, the bulk of the in vitro studies strongly favor the idea that transformed myoepithelial cells are actual ancestors to pleomorphic adenomas. It seems feasible that the unique histopathologic features of pleomorphic adenomas, in which stromal and epithelial areas coexist, thus justifying References 1. Witsell DL, Weisler MC, Livanos E, Bova-Hill C, Gilmer TM. Unique chromosomal rearrangement and mucin production in a novel salivary myoepithelial cell strain . Arch Otolaryngol Head Neck Surg . 1993;119:1151-1157.Crossref 2. Gallo O, Bani D, Toccafondi G, Almerigogna F, Fini-Storchi O. Characterization of novel cell line from pleomorphic adenoma of the parotid gland with myoepithelial phenotype and producing interleukin 6 as an autocrine growth factor . Cancer . 1992;70:559-568.Crossref 3. Shirasuna K, Sato M, Miyazaki T. A myoepithelial cell line established from a human pleomorphic adenoma arising in minor salivary gland . Cancer . 1980; 45:297-305.Crossref 4. Shah JP, Ihde JK. Salivary gland tumors . Curr Probl Surg . 1990;27:775-843.Crossref 5. Gallo O, Bani D, Giudizi MG, et al. Spontaneous in vitro differentiation of a myoepithelial cell line (PA 16/23) from a pleomorphic adenoma of the parotid gland is associated with reduced production of the autocrine growth factor interleukin-6. BrJ Cancer. In press.

Journal

Archives of Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Jun 1, 1994

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