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Topical Ciprofloxacin vs Intramuscular Gentamicin for Chronic Otitis Media

Topical Ciprofloxacin vs Intramuscular Gentamicin for Chronic Otitis Media Abstract • Clinical and bacteriological efficacy of topical ciprofloxacin hydrochloride was compared with that of intramuscular gentamicin sulfate in two groups composed of 30 patients each, all of whom were affected by chronic otitis media in the acute stage. Antibiotics were randomly given for 5 to 10 days according to the following schedules: ciprofloxacin hydrochloride, four drops (250 mg/mL in saline solution) administered locally twice a day, or gentamicin sulfate, 80 mg administered intramuscularly twice a day. We admitted to the study only adult patients affected by chronic otitis media in the acute stage with perforation of the tympanic membrane, without cholesteatoma, whose bacteriological culture was positive for Pseudomonas susceptible in vitro to ciprofloxacin and gentamicin. The clinical and bacteriological response was stated 12 hours after the interruption of the treatment, and 2 and 3 weeks later (follow-up). A favorable clinical result was observed in 26 (87%) of 30 patients under ciprofloxacin treatment; in 30 patients receiving gentamicin, a favorable clinical response was observed in 20 (66%) and bacteriological eradication in 13 (43%). No relapse at the follow-up was observed. Topical ciprofloxacin seems to be more effective than intramuscular gentamicin in curing Pseudomonas-caused chronic otitis media in the acute stage. (Arch Otolaryngol Head Neck Surg. 1992;118:842-844) References 1. Jokipii AMM, Karma P, Ojala K, Jokipii L. Anaerobic bacteria in chronic otitis media . Arch Otolaryngol Head Neck Surg. 1977;103:278-280.Crossref 2. Brook I. Chronic otitis media: microbiological studies . AJDC . 1980; 134:564-568. 3. Ojala R. Bacteriology of chronic otitis media correlated with the clinical state of the ears . Arch Otolaryngol Head Neck Surg. 1982;234:65-71. 4. Sprinkle PL, Veltri RW. Microbiology of the middle ear and nasopharynx . Ann Otol Rhinol Laryngol . 1970;83( (suppl 11) ):59-70. 5. Palva T, Hallstrom O. Bacteriology of chronic otitis media results of analysis from the ear canal and from the operating cavity . Arch Otolaryngol Head Neck Surg . 1965;82:459-464.Crossref 6. Ostfeld E, Rubenstien E. Acute gram-negative bacillary infections of the middle ear and mastoid . Ann Otol Rhinol Laryngol . 1980;89:33-36. 7. Ojala K, Sorri M, Riihikangas P, Palva A. Comparison of pre- and postoperative bacteriology of chronic ear . J Laryngol Otol. 1981;95:1023-1029.Crossref 8. Ginsberg IA, Rundnick MD, Huber PS. Aminoglycoside ototoxicity following middle ear infection, III: comparative quantitative analysis . Ann Otol Rhinol Laryngol . 1980;89( (suppl 77) ):17-24. 9. Ruben RJ, Daly JF. Neomicin ototoxicity and nephrotoxicity . Laryngoscope . 1968;78:2297-2301.Crossref 10. Morizono T, Johnstone BM. Ototoxicity of topically applied gentamicin using a statistical analysis of electrophysiological measurement . Acta Otolaryngol . 1975;80:389-393.Crossref 11. Esposito S, D'Errico G, Montanaro C. Topical and oral treatment of chronic otitis media with ciprofloxacin . Arch Otolaryngol Head Neck Surg. 1990;116:557-559.Crossref 12. Fujimaki Y, Kawamura S, Watanabe H, Itabashi T, Nakamura M, Deguchi K. Fundamental and clinical studies on Bay o 9867 (ciprofloxacin) in otorhinolaryngological field . Chemotherapy . 1985;33( (suppl 7) ):970-977. 13. Mori Y, Baba S, Kinoshita H, et al. Laboratory and clinical study on Bay o 9867 in otorhinolaryngological field . Chemotherapy . 1985;33( (suppl 7) ):978-985. 14. Van Der Heyning PH, Pattyn SR, Valcke HD. Ciprofloxacin in oral treatment of ear infection . Pharm Weekbl Sci. 1986;8:63-66. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Topical Ciprofloxacin vs Intramuscular Gentamicin for Chronic Otitis Media

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1992.01880080064014
Publisher site
See Article on Publisher Site

Abstract

Abstract • Clinical and bacteriological efficacy of topical ciprofloxacin hydrochloride was compared with that of intramuscular gentamicin sulfate in two groups composed of 30 patients each, all of whom were affected by chronic otitis media in the acute stage. Antibiotics were randomly given for 5 to 10 days according to the following schedules: ciprofloxacin hydrochloride, four drops (250 mg/mL in saline solution) administered locally twice a day, or gentamicin sulfate, 80 mg administered intramuscularly twice a day. We admitted to the study only adult patients affected by chronic otitis media in the acute stage with perforation of the tympanic membrane, without cholesteatoma, whose bacteriological culture was positive for Pseudomonas susceptible in vitro to ciprofloxacin and gentamicin. The clinical and bacteriological response was stated 12 hours after the interruption of the treatment, and 2 and 3 weeks later (follow-up). A favorable clinical result was observed in 26 (87%) of 30 patients under ciprofloxacin treatment; in 30 patients receiving gentamicin, a favorable clinical response was observed in 20 (66%) and bacteriological eradication in 13 (43%). No relapse at the follow-up was observed. Topical ciprofloxacin seems to be more effective than intramuscular gentamicin in curing Pseudomonas-caused chronic otitis media in the acute stage. (Arch Otolaryngol Head Neck Surg. 1992;118:842-844) References 1. Jokipii AMM, Karma P, Ojala K, Jokipii L. Anaerobic bacteria in chronic otitis media . Arch Otolaryngol Head Neck Surg. 1977;103:278-280.Crossref 2. Brook I. Chronic otitis media: microbiological studies . AJDC . 1980; 134:564-568. 3. Ojala R. Bacteriology of chronic otitis media correlated with the clinical state of the ears . Arch Otolaryngol Head Neck Surg. 1982;234:65-71. 4. Sprinkle PL, Veltri RW. Microbiology of the middle ear and nasopharynx . Ann Otol Rhinol Laryngol . 1970;83( (suppl 11) ):59-70. 5. Palva T, Hallstrom O. Bacteriology of chronic otitis media results of analysis from the ear canal and from the operating cavity . Arch Otolaryngol Head Neck Surg . 1965;82:459-464.Crossref 6. Ostfeld E, Rubenstien E. Acute gram-negative bacillary infections of the middle ear and mastoid . Ann Otol Rhinol Laryngol . 1980;89:33-36. 7. Ojala K, Sorri M, Riihikangas P, Palva A. Comparison of pre- and postoperative bacteriology of chronic ear . J Laryngol Otol. 1981;95:1023-1029.Crossref 8. Ginsberg IA, Rundnick MD, Huber PS. Aminoglycoside ototoxicity following middle ear infection, III: comparative quantitative analysis . Ann Otol Rhinol Laryngol . 1980;89( (suppl 77) ):17-24. 9. Ruben RJ, Daly JF. Neomicin ototoxicity and nephrotoxicity . Laryngoscope . 1968;78:2297-2301.Crossref 10. Morizono T, Johnstone BM. Ototoxicity of topically applied gentamicin using a statistical analysis of electrophysiological measurement . Acta Otolaryngol . 1975;80:389-393.Crossref 11. Esposito S, D'Errico G, Montanaro C. Topical and oral treatment of chronic otitis media with ciprofloxacin . Arch Otolaryngol Head Neck Surg. 1990;116:557-559.Crossref 12. Fujimaki Y, Kawamura S, Watanabe H, Itabashi T, Nakamura M, Deguchi K. Fundamental and clinical studies on Bay o 9867 (ciprofloxacin) in otorhinolaryngological field . Chemotherapy . 1985;33( (suppl 7) ):970-977. 13. Mori Y, Baba S, Kinoshita H, et al. Laboratory and clinical study on Bay o 9867 in otorhinolaryngological field . Chemotherapy . 1985;33( (suppl 7) ):978-985. 14. Van Der Heyning PH, Pattyn SR, Valcke HD. Ciprofloxacin in oral treatment of ear infection . Pharm Weekbl Sci. 1986;8:63-66.

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Aug 1, 1992

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