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T. Palva, O. Hallstrom (1965)
Bacteriology of chronic otitis media. Results of analyses from the ear canal and from the operative cavity.Archives of otolaryngology, 82 4
I. Ginsberg, M. Rudnick, P. Huber (1980)
III. Comparative Quantitative AnalysisAnnals of Otology, Rhinology & Laryngology, 89
J. Sadé (1974)
The Biopathology of Secretory Otitis MediaAnnals of Otology, Rhinology & Laryngology, 83
藤巻 豊, 河村 正三, 渡辺 洋, 板橋 隆嗣, 中村 美彌子, 出口 浩一 (1985)
耳鼻咽喉科領域感染に対するBAY o 9867の臨床的・基礎的検討Chemotherapy, 33
K. Ojala, M. Sorri, P. Riihikangas, P. Sipilä (1981)
Comparison of pre- and post-operative bacteriology of chronic earsThe Journal of Laryngology & Otology, 95
Karma P Jokipii AMM (1977)
Anaerobic bacteria in chronic otitis mediaArch Otolaryngol Head Neck Surg., 103
Hallstrom O Palva T (1965)
Bacteriology of chronic otitis media results of analysis from the ear canal and from the operating cavityArch Otolaryngol Head Neck Surg, 82
T. Morizono, B. Johnstone (1975)
Ototoxicity of topically applied gentamicin using a statistical analysis of electrophysiological measurement.Acta oto-laryngologica, 80 5-6
Brook I (1980)
Chronic otitis media: microbiological studiesAJDC, 134
Rundnick MD Ginsberg IA (1980)
Aminoglycoside ototoxicity following middle ear infection, III: comparative quantitative analysisAnn Otol Rhinol Laryngol, 89
Baba S Mori Y (1985)
Laboratory and clinical study on Bay o 9867 in otorhinolaryngological fieldChemotherapy, 33
P. Sprinkle, R. Veltri (1971)
Microbiology of the Middle Ear and NasopharynxAnnals of Otology, Rhinology & Laryngology, 80
A. Jokipii, P. Karma, K. Ojala, L. Jokipii (1977)
Anaerobic bacteria in chronic otitis media.Archives of otolaryngology, 103 5
森 慶人, 馬場 駿吉, 木下 治二, 鈴木 賢二, 島田 純一郎, 丸尾 猛, 伊藤 晴夫 (1985)
耳鼻咽喉科領域感染症におけるBAYo9867 (Ciprofloxacin) の基礎的ならびに臨床的検討Chemotherapy, 33
D'Errico G Esposito S (1990)
Topical and oral treatment of chronic otitis media with ciprofloxacinArch Otolaryngol Head Neck Surg., 116
E. Ostfeld, E. Rubinstein (1980)
Acute Gram-Negative Bacillary Infections of Middle Ear and MastoidAnnals of Otology, Rhinology & Laryngology, 89
S. Esposito, G. D'errico, C. Montanaro (1990)
Topical and oral treatment of chronic otitis media with ciprofloxacin. A preliminary study.Archives of otolaryngology--head & neck surgery, 116 5
Pattyn SR Van Der Heyning PH (1986)
Ciprofloxacin in oral treatment of ear infectionPharm Weekbl Sci., 8
Daly JF Ruben RJ (1968)
Neomicin ototoxicity and nephrotoxicityLaryngoscope, 78
Kawamura S Fujimaki Y (1985)
Fundamental and clinical studies on Bay o 9867 (ciprofloxacin) in otorhinolaryngological fieldChemotherapy, 33
Ojala R (1982)
Bacteriology of chronic otitis media correlated with the clinical state of the earsArch Otolaryngol Head Neck Surg., 234
Abstract • Clinical and bacteriological efficacy of topical ciprofloxacin hydrochloride was compared with that of intramuscular gentamicin sulfate in two groups composed of 30 patients each, all of whom were affected by chronic otitis media in the acute stage. Antibiotics were randomly given for 5 to 10 days according to the following schedules: ciprofloxacin hydrochloride, four drops (250 mg/mL in saline solution) administered locally twice a day, or gentamicin sulfate, 80 mg administered intramuscularly twice a day. We admitted to the study only adult patients affected by chronic otitis media in the acute stage with perforation of the tympanic membrane, without cholesteatoma, whose bacteriological culture was positive for Pseudomonas susceptible in vitro to ciprofloxacin and gentamicin. The clinical and bacteriological response was stated 12 hours after the interruption of the treatment, and 2 and 3 weeks later (follow-up). A favorable clinical result was observed in 26 (87%) of 30 patients under ciprofloxacin treatment; in 30 patients receiving gentamicin, a favorable clinical response was observed in 20 (66%) and bacteriological eradication in 13 (43%). No relapse at the follow-up was observed. Topical ciprofloxacin seems to be more effective than intramuscular gentamicin in curing Pseudomonas-caused chronic otitis media in the acute stage. (Arch Otolaryngol Head Neck Surg. 1992;118:842-844) References 1. Jokipii AMM, Karma P, Ojala K, Jokipii L. Anaerobic bacteria in chronic otitis media . Arch Otolaryngol Head Neck Surg. 1977;103:278-280.Crossref 2. Brook I. Chronic otitis media: microbiological studies . AJDC . 1980; 134:564-568. 3. Ojala R. Bacteriology of chronic otitis media correlated with the clinical state of the ears . Arch Otolaryngol Head Neck Surg. 1982;234:65-71. 4. Sprinkle PL, Veltri RW. Microbiology of the middle ear and nasopharynx . Ann Otol Rhinol Laryngol . 1970;83( (suppl 11) ):59-70. 5. Palva T, Hallstrom O. Bacteriology of chronic otitis media results of analysis from the ear canal and from the operating cavity . Arch Otolaryngol Head Neck Surg . 1965;82:459-464.Crossref 6. Ostfeld E, Rubenstien E. Acute gram-negative bacillary infections of the middle ear and mastoid . Ann Otol Rhinol Laryngol . 1980;89:33-36. 7. Ojala K, Sorri M, Riihikangas P, Palva A. Comparison of pre- and postoperative bacteriology of chronic ear . J Laryngol Otol. 1981;95:1023-1029.Crossref 8. Ginsberg IA, Rundnick MD, Huber PS. Aminoglycoside ototoxicity following middle ear infection, III: comparative quantitative analysis . Ann Otol Rhinol Laryngol . 1980;89( (suppl 77) ):17-24. 9. Ruben RJ, Daly JF. Neomicin ototoxicity and nephrotoxicity . Laryngoscope . 1968;78:2297-2301.Crossref 10. Morizono T, Johnstone BM. Ototoxicity of topically applied gentamicin using a statistical analysis of electrophysiological measurement . Acta Otolaryngol . 1975;80:389-393.Crossref 11. Esposito S, D'Errico G, Montanaro C. Topical and oral treatment of chronic otitis media with ciprofloxacin . Arch Otolaryngol Head Neck Surg. 1990;116:557-559.Crossref 12. Fujimaki Y, Kawamura S, Watanabe H, Itabashi T, Nakamura M, Deguchi K. Fundamental and clinical studies on Bay o 9867 (ciprofloxacin) in otorhinolaryngological field . Chemotherapy . 1985;33( (suppl 7) ):970-977. 13. Mori Y, Baba S, Kinoshita H, et al. Laboratory and clinical study on Bay o 9867 in otorhinolaryngological field . Chemotherapy . 1985;33( (suppl 7) ):978-985. 14. Van Der Heyning PH, Pattyn SR, Valcke HD. Ciprofloxacin in oral treatment of ear infection . Pharm Weekbl Sci. 1986;8:63-66.
Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Aug 1, 1992
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