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K. Tamura, Y. Shibata, Y. Matsuda, N. Ishida (1981)
Isolation and characterization of an immunosuppressive acidic protein from ascitic fluids of cancer patients.Cancer research, 41 8
T. Yamanaka, J. Cumella, C. Parker, J. Bernstein, P. Ogra (1983)
Immunologic aspects of otitis media with effusion. II. Nature of cell-mediated immunosuppressive activity in middle ear fluid.The Journal of infectious diseases, 147 5
Dake Y Kakiuchi H (1988)
Recent Advances in Otitis Media With Effusion
M. Fujii, N. Takahashi, H. Hayashi, K. Matsunaga, C. Yoshikumi (1987)
Purification and characterization of immunosuppressive (IS) substance obtained from ascitic fluids of patients with gastrointestinal cancer.Clinical biochemistry, 20 3
Yamanaka T Bernstein JM (1985)
Immunobiology, Autoimmunity, Transplantation in Otorhinolaryngology
Abstract • In this study, experimental otitis media was created in the chinchilla by direct middle ear challenge with Escherichia coli endotoxin, Streptococcus pneumoniae, Haemophilus influenzae, or Pseudomonas aeruginosa. The effusions recovered from the chinchillas in all four challenge groups were shown to inhibit the lymphoproliferative response of chinchilla peripheral blood lymphocytes to stimulation with phytohemagglutinin. The effect was dose dependent, and for effusions of infectious origin, the degree of inhibition was directly related to the duration of infection. Presence of the inhibitor in plasma was undocumented, suggesting a local production within the middle ear. Lymphocytes from middle ears infected with bacteria but not middle ears challenged with endotoxin were hyporesponsive or nonresponsive to stimulation with phytohemagglutinin. These results confirm the presence of an inhibitor of the lymphoproliferative response in experimental otitis media of different etiologies. (Arch Otolaryngol Head Neck Surg. 1992;118:749-752) References 1. Bernstein JM, Yamanaka T, Cumella J, Ogra PL, Park B. Some observations on lymphocyte and macrophage function in middle ear effusions . In: Veldman JE, McCabe BF, Huizing EH, Mygind N, eds. Immunobiology, Autoimmunity, Transplantation in Otorhinolaryngology . Amsterdam, the Netherlands: Kugler Publications; 1985:51. 2. Yamanaka T, Cumella J, Parker C, Bernstein JM, Ogra PL. Immunologic aspects of otitis media with effusion, II: nature of cell-mediated immunosuppressive activity in middle ear fluid . J Infect Dis . 1983;147:794-799.Crossref 3. Tamura K, Shbata Y, Matsuda Y, Ishida N. Isolation and characterization of an immunosuppressive acidic protein from ascitic fluids of cancer patients . Cancer Res . 1981;41:3244-3252. 4. Fugi M,Takahashi N, Hayashi H, Matsunaga K, Yoshikumi C. Purification and characterization of immunosuppressive substance obtained from ascitic fluids of patients with gastrointestinal cancer . Clin Biochem . 1987;20:188-189. 5. Kakiuchi H, Dake Y, Tabata T. Immunogenesis of otitis media with effusion: with special reference to immunosuppressive factors in the middle ear . In: Lim DJ, Bluestone CD, Klein JO, Nelson JD, eds. Recent Advances in Otitis Media With Effusion . Toronto, Ontario: BC Decker Inc; 1988:153-156.
Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Jul 1, 1992
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