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Nucleolar Organizer Regions in Paragangliomas of the Head and Neck

Nucleolar Organizer Regions in Paragangliomas of the Head and Neck Abstract • The clinical behavior of head-and-neck paragangliomas cannot be accurately predicted using standard histologic criteria. Immunohistochemical profiles have proved to be prognostically helpful; however, other independent indicators of prognosis are needed. Tissue markers of proliferative activity include argyrophilic nucleolar organizer regions (AgNOR), which are proteins specifically associated with loops of transcriptionally active ribosomal DNA. Fifteen paragangliomas of the head and neck were divided into solitary nonrecurrent (n = 8), recurrent or locally invasive (n = 4), and multiple (n = 1), or malignant (n = 2) groups. The mean AgNOR count per cell was statistically different between the solitary nonrecurrent and the combined other poorer prognosis groups, suggesting that it may be useful as an independent indicator of biologic behavior. The wide variation in AgNOR counts within groups and the overlap of counts between groups limit, however, the predictive value of this technique for individual tumors. (Arch Otolaryngol Head Neck Surg. 1992;118:380-383) References 1. Glenner GG, Grimley PM. Tumors of the extra-adrenal paraganglion system (including chemoreceptors) . In: Atlas of Tumor Pathology . Washington, DC: Armed Forces Institute of Pathology; 1974:1-90. 2. Kliewer KE, Cochran AJ. A review of the histology, ultrastructure, immunohistology, and molecular biology of extra-adrenal paragangliomas . Arch Pathol Lab Med . 1989;113:1209-1218. 3. Kliewer KE, Wen D-R, Cancilla PA, Cochran AJ. Paragangliomas: assessment of prognosis by histologic, immunohistochemical, and ultrastructural techniques . Hum Pathol . 1989;20:29-39.Crossref 4. Lack EE, Cubilla AL, Woodruff JM. Paragangliomas of the head and neck region: a pathologic study of tumors from 71 patients . Hum Pathol . 1979;10:191-218.Crossref 5. Barnes L, Taylor SR. Carotid body paragangliomas: a clinicopathologic and DNA analysis of 13 tumors . Arch Otolaryngol Head Neck Surg . 1990;116:447-453.Crossref 6. Capella C, Riva C, Cornaggia M, Chiaravalli AM, Frigerio B. Histopathology, cytology and cytochemistry of pheochromocytomas and paragangliomas including chemodectomas . Path Res Pract . 1988;183:176-187.Crossref 7. Linnoila RI, Keiser HR, Steinberg SM, Lack EE. Histopathology of benign versus malignant sympathoadrenal paragangliomas: clinicopathologic study of 120 cases including unusual histologic features . Hum Pathol . 1990;21:1168-1180.Crossref 8. Donnhuijsen K, Schmidt U, Hirche H, van Beuningen D, Budach V. Changes in mitotic rate and cell cycle fractions caused by delayed fixation . Hum Pathol . 1990;21:709-714.Crossref 9. Quinn CM, Wright NA. The clinical assessment of proliferation and growth in human tumors: evaluation of methods and application as prognostic variables . J Pathol . 1990;160:93-102.Crossref 10. Ruschoff J, Plate K, Bittinger A, Thomas C. Nucleolar organizer regions (NORs): basic concepts and practical applications in tumor pathology . Path Res Pract . 1989;185:878-885.Crossref 11. Howell WM, Black DA. Controlled silver staining of nucleolus organizer regions with a protective colloidal developer: a one step method . Experientia . 1980;36:1014-1015.Crossref 12. Ploton D, Menager M, Jeannesson P, Himber G, Pigeon F, Adnet JJ. Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level . Histochem J . 1986;18:5-14.Crossref 13. Dervan PA, Gilmartin LG, Loftus BM, Carney DN. Breast carcinoma kinetics: argyrophilic nucleolar organizer region counts correlate with Ki67 scores . Am J Clin Pathol . 1989;92:401-407. 14. Egan MJ, Raafat F, Crocker J, Smith K. Nucleolar organizer regions in small cell tumors of childhood . J Pathol . 1987;153:275-280.Crossref 15. Maier H, Morimura T, Ofner D, Hallbrucker C, Kitz K, Budka H. Argyrophilic nucleolar organizer region proteins (Ag-NORs) in human brain tumors: relations with grade of malignancy and proliferation indices . Acta Neuropathol . 1990;80:156-162.Crossref 16. Plate KH, Ruschoff J, Behnke J, Mennel HD. Proliferative potential of human brain tumors as assessed by nucleolar organizer regions (AgNORs) and Ki67-immunoreactivity . Acta Neurochir (Wien) . 1990; 104:103-109.Crossref 17. Chin LS, Hinton DR. The standardized assessment of argyrophilic nucleolar organizer regions in meningeal tumors . J Neurosurg. 1991; 74:590-596.Crossref 18. Crocker J, Egan MJ. Correlation between NOR sizes and numbers in non-Hodgkin's lymphomas . J Pathol . 1988;156:233-239.Crossref 19. Crocker J, Boldy DA, Egan MJ. How should we count AgNORS? Proposals for a standardized approach . J Pathol . 1989;158:185-188.Crossref 20. Ruschoff J, Plate KH, Contracor H, Kern S, Zimmermann R, Thomas C. Evaluation of nucleolus organizer regions (NORs) by automatic image analysis: a contribution to standardization . J Pathol . 1990; 161:113-118.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Nucleolar Organizer Regions in Paragangliomas of the Head and Neck

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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1992.01880040038007
Publisher site
See Article on Publisher Site

Abstract

Abstract • The clinical behavior of head-and-neck paragangliomas cannot be accurately predicted using standard histologic criteria. Immunohistochemical profiles have proved to be prognostically helpful; however, other independent indicators of prognosis are needed. Tissue markers of proliferative activity include argyrophilic nucleolar organizer regions (AgNOR), which are proteins specifically associated with loops of transcriptionally active ribosomal DNA. Fifteen paragangliomas of the head and neck were divided into solitary nonrecurrent (n = 8), recurrent or locally invasive (n = 4), and multiple (n = 1), or malignant (n = 2) groups. The mean AgNOR count per cell was statistically different between the solitary nonrecurrent and the combined other poorer prognosis groups, suggesting that it may be useful as an independent indicator of biologic behavior. The wide variation in AgNOR counts within groups and the overlap of counts between groups limit, however, the predictive value of this technique for individual tumors. (Arch Otolaryngol Head Neck Surg. 1992;118:380-383) References 1. Glenner GG, Grimley PM. Tumors of the extra-adrenal paraganglion system (including chemoreceptors) . In: Atlas of Tumor Pathology . Washington, DC: Armed Forces Institute of Pathology; 1974:1-90. 2. Kliewer KE, Cochran AJ. A review of the histology, ultrastructure, immunohistology, and molecular biology of extra-adrenal paragangliomas . Arch Pathol Lab Med . 1989;113:1209-1218. 3. Kliewer KE, Wen D-R, Cancilla PA, Cochran AJ. Paragangliomas: assessment of prognosis by histologic, immunohistochemical, and ultrastructural techniques . Hum Pathol . 1989;20:29-39.Crossref 4. Lack EE, Cubilla AL, Woodruff JM. Paragangliomas of the head and neck region: a pathologic study of tumors from 71 patients . Hum Pathol . 1979;10:191-218.Crossref 5. Barnes L, Taylor SR. Carotid body paragangliomas: a clinicopathologic and DNA analysis of 13 tumors . Arch Otolaryngol Head Neck Surg . 1990;116:447-453.Crossref 6. Capella C, Riva C, Cornaggia M, Chiaravalli AM, Frigerio B. Histopathology, cytology and cytochemistry of pheochromocytomas and paragangliomas including chemodectomas . Path Res Pract . 1988;183:176-187.Crossref 7. Linnoila RI, Keiser HR, Steinberg SM, Lack EE. Histopathology of benign versus malignant sympathoadrenal paragangliomas: clinicopathologic study of 120 cases including unusual histologic features . Hum Pathol . 1990;21:1168-1180.Crossref 8. Donnhuijsen K, Schmidt U, Hirche H, van Beuningen D, Budach V. Changes in mitotic rate and cell cycle fractions caused by delayed fixation . Hum Pathol . 1990;21:709-714.Crossref 9. Quinn CM, Wright NA. The clinical assessment of proliferation and growth in human tumors: evaluation of methods and application as prognostic variables . J Pathol . 1990;160:93-102.Crossref 10. Ruschoff J, Plate K, Bittinger A, Thomas C. Nucleolar organizer regions (NORs): basic concepts and practical applications in tumor pathology . Path Res Pract . 1989;185:878-885.Crossref 11. Howell WM, Black DA. Controlled silver staining of nucleolus organizer regions with a protective colloidal developer: a one step method . Experientia . 1980;36:1014-1015.Crossref 12. Ploton D, Menager M, Jeannesson P, Himber G, Pigeon F, Adnet JJ. Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level . Histochem J . 1986;18:5-14.Crossref 13. Dervan PA, Gilmartin LG, Loftus BM, Carney DN. Breast carcinoma kinetics: argyrophilic nucleolar organizer region counts correlate with Ki67 scores . Am J Clin Pathol . 1989;92:401-407. 14. Egan MJ, Raafat F, Crocker J, Smith K. Nucleolar organizer regions in small cell tumors of childhood . J Pathol . 1987;153:275-280.Crossref 15. Maier H, Morimura T, Ofner D, Hallbrucker C, Kitz K, Budka H. Argyrophilic nucleolar organizer region proteins (Ag-NORs) in human brain tumors: relations with grade of malignancy and proliferation indices . Acta Neuropathol . 1990;80:156-162.Crossref 16. Plate KH, Ruschoff J, Behnke J, Mennel HD. Proliferative potential of human brain tumors as assessed by nucleolar organizer regions (AgNORs) and Ki67-immunoreactivity . Acta Neurochir (Wien) . 1990; 104:103-109.Crossref 17. Chin LS, Hinton DR. The standardized assessment of argyrophilic nucleolar organizer regions in meningeal tumors . J Neurosurg. 1991; 74:590-596.Crossref 18. Crocker J, Egan MJ. Correlation between NOR sizes and numbers in non-Hodgkin's lymphomas . J Pathol . 1988;156:233-239.Crossref 19. Crocker J, Boldy DA, Egan MJ. How should we count AgNORS? Proposals for a standardized approach . J Pathol . 1989;158:185-188.Crossref 20. Ruschoff J, Plate KH, Contracor H, Kern S, Zimmermann R, Thomas C. Evaluation of nucleolus organizer regions (NORs) by automatic image analysis: a contribution to standardization . J Pathol . 1990; 161:113-118.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Apr 1, 1992

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