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Biodistribution of Indium 111-Labeled Dihematoporphyrin Ether in Papillomas and Body Tissues: Relevance to Photodynamic Therapy

Biodistribution of Indium 111-Labeled Dihematoporphyrin Ether in Papillomas and Body Tissues:... Abstract • Hematoporphyrin derivative and its newly purified form, dihematoporphyrin ether, have been shown to localize selectively in malignant tissues and virally induced papillomas. Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by UV light. These findings are largely subjective, and a direct correlation to its use as a photosensitizing agent to selectively kill transformed cells when activated by an appropriate wavelength of light could not be made. The efficacy of dihematoporphyrin ether photodynamic therapy to selectively kill papillomavirus-transformed cells is based on the increased localization of dihematoporphyrin ether within these tissues as compared with normal tissues. Using cottontail rabbit papillomavirus, cutaneous papillomas were induced on the backs of Dutch belted rabbits. Dihematoporphyrin ether was labeled with indium 111 and intravenously injected into the rabbits. The animals were scanned twice daily for indium 111 activity on a large-field-of-view gamma camera. At 50 hours after injection, the rabbits were killed and papillomas, skin, and major organs collected for biodistribution studies. The results of this study and their relationship to dihematoporphyrin ether photodynamic therapy for the treatment of virally induced papilloma disease is discussed. (Arch Otolaryngol Head Neck Surg. 1989;115:845:847) References 1. Shikowitz MJ, Steinberg BM, Abramson AL. Hematoporphyrin derivative therapy of papillomas: experimental study . Arch Otolaryngol Head Neck Surg . 1986;112:42-46.Crossref 2. Shikowitz MJ, Steinberg BM, Galli RL, Wettstein FO. Molecular analysis of cottontail rabbit papillomavirus-induced papillomas treated with hematoporphyrin photodynamic therapy . In: Steinberg B, Brandsma J, Taichman L, eds. Cancer Cells 5: Papillomaviruses . Cold Spring Harbor, NY: Cold Spring Harbor Press; 1987:411-416. 3. Shikowitz MJ, Steinberg BM, Galli RL, Abramson AL. Histological and molecular analysis of cottontail rabbit papillomavirus-induced papillomas treated with hematoporphyrin derivative photodynamic therapy . Arch Otolaryngol Head Neck Surg . 1988;114:175-178.Crossref 4. Henderson RW, Christie GS, Clezy PS, Lineman J. Hematoporphyrin diacetate: a probe to distinguish malignant from normal tissue by selective fluorescence . Br J Exp Pathol . 1980;61:345-349. 5. Lipson RL, Baldes EJ, Olsen AM. The use of a derivative of hematoporphyrin in tumor detection . JNCI . 1961;26:1-11. 6. Lipson RL, Baldes EJ, Gray MJ. Hematoporphyrin derivative for detection and management of cancer . Cancer . 1967;20:2255-2257.Crossref 7. Wong DW. A simple and efficient method of labeling hematoporphyrin derivative with In-111 . Int J Appl Radiat Isot . 1984;35:691-692.Crossref 8. Jesionek A, Tappeiner VH. Zur behandlung der hautcarcinomemet fluoresciecenden stoffen . MMW . 1903;47:2042-2044. 9. Gomer CJ, Dougherty TJ. Determination of ′′H and ′′C hematoporphyrin derivative distribution in malignant and normal tissue . Cancer Res . 1979;39:146-151. 10. Muller-Eberhard U. Hemopexin . N Engl J Med . 1970;283:1090-1094.Crossref 11. Muller-Eberhard U, Morgan WT. Porphyrin-binding proteins in serum . Bull NY Acad Sci . 1975;244:626-629. 12. Evensen J, Moan J, Hindar A, Sommer S. Tissue distribution of 3H-hematoporphyrin derivative and its main components, 67 Ga and 131 I-albumin in mice bearing Lewis lung carcinoma . In: Diorin D, Gomer C, eds. Porphyrin Localization and Treatment of Tumors . New York, NY: Alan R Liss Inc; 1984:541-562. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Biodistribution of Indium 111-Labeled Dihematoporphyrin Ether in Papillomas and Body Tissues: Relevance to Photodynamic Therapy

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1989.01860310083028
Publisher site
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Abstract

Abstract • Hematoporphyrin derivative and its newly purified form, dihematoporphyrin ether, have been shown to localize selectively in malignant tissues and virally induced papillomas. Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by UV light. These findings are largely subjective, and a direct correlation to its use as a photosensitizing agent to selectively kill transformed cells when activated by an appropriate wavelength of light could not be made. The efficacy of dihematoporphyrin ether photodynamic therapy to selectively kill papillomavirus-transformed cells is based on the increased localization of dihematoporphyrin ether within these tissues as compared with normal tissues. Using cottontail rabbit papillomavirus, cutaneous papillomas were induced on the backs of Dutch belted rabbits. Dihematoporphyrin ether was labeled with indium 111 and intravenously injected into the rabbits. The animals were scanned twice daily for indium 111 activity on a large-field-of-view gamma camera. At 50 hours after injection, the rabbits were killed and papillomas, skin, and major organs collected for biodistribution studies. The results of this study and their relationship to dihematoporphyrin ether photodynamic therapy for the treatment of virally induced papilloma disease is discussed. (Arch Otolaryngol Head Neck Surg. 1989;115:845:847) References 1. Shikowitz MJ, Steinberg BM, Abramson AL. Hematoporphyrin derivative therapy of papillomas: experimental study . Arch Otolaryngol Head Neck Surg . 1986;112:42-46.Crossref 2. Shikowitz MJ, Steinberg BM, Galli RL, Wettstein FO. Molecular analysis of cottontail rabbit papillomavirus-induced papillomas treated with hematoporphyrin photodynamic therapy . In: Steinberg B, Brandsma J, Taichman L, eds. Cancer Cells 5: Papillomaviruses . Cold Spring Harbor, NY: Cold Spring Harbor Press; 1987:411-416. 3. Shikowitz MJ, Steinberg BM, Galli RL, Abramson AL. Histological and molecular analysis of cottontail rabbit papillomavirus-induced papillomas treated with hematoporphyrin derivative photodynamic therapy . Arch Otolaryngol Head Neck Surg . 1988;114:175-178.Crossref 4. Henderson RW, Christie GS, Clezy PS, Lineman J. Hematoporphyrin diacetate: a probe to distinguish malignant from normal tissue by selective fluorescence . Br J Exp Pathol . 1980;61:345-349. 5. Lipson RL, Baldes EJ, Olsen AM. The use of a derivative of hematoporphyrin in tumor detection . JNCI . 1961;26:1-11. 6. Lipson RL, Baldes EJ, Gray MJ. Hematoporphyrin derivative for detection and management of cancer . Cancer . 1967;20:2255-2257.Crossref 7. Wong DW. A simple and efficient method of labeling hematoporphyrin derivative with In-111 . Int J Appl Radiat Isot . 1984;35:691-692.Crossref 8. Jesionek A, Tappeiner VH. Zur behandlung der hautcarcinomemet fluoresciecenden stoffen . MMW . 1903;47:2042-2044. 9. Gomer CJ, Dougherty TJ. Determination of ′′H and ′′C hematoporphyrin derivative distribution in malignant and normal tissue . Cancer Res . 1979;39:146-151. 10. Muller-Eberhard U. Hemopexin . N Engl J Med . 1970;283:1090-1094.Crossref 11. Muller-Eberhard U, Morgan WT. Porphyrin-binding proteins in serum . Bull NY Acad Sci . 1975;244:626-629. 12. Evensen J, Moan J, Hindar A, Sommer S. Tissue distribution of 3H-hematoporphyrin derivative and its main components, 67 Ga and 131 I-albumin in mice bearing Lewis lung carcinoma . In: Diorin D, Gomer C, eds. Porphyrin Localization and Treatment of Tumors . New York, NY: Alan R Liss Inc; 1984:541-562.

Journal

Archives of Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Jul 1, 1989

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