Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Effects of Pentoxifylline on Random Skin Flap Survival

The Effects of Pentoxifylline on Random Skin Flap Survival Abstract • Random skin flaps are an important and frequently used technique in head and neck reconstruction. Pentoxifylline has been shown to improve the deformability of red blood cells by increasing their intracellular adenosine triphosphate content and, therefore, improving their flow properties. This is especially important in ischemia and low blood flow states present in the distal portions of random skin flaps. The rheologic properties of pentoxifylline were studied in the swine model. Swine in group I (eight flaps) served as controls with no pharmacologic manipulations. Swine in group II (16 flaps) received pentoxifylline (20 mg/kg/d) for ten days preoperatively and ten days postoperatively. Necrosis in swine in group I (controls) averaged 32.6%, which substantiated previous reports. Necrosis in swine in group II (pentoxifylline) averaged 2.57%. This study has shown a statistically significant enhancement of random skin flap survival using pentoxifylline in a swine model. (Arch Otolaryngol Head Neck Surg 1989;115:179-181) References 1. Takayanagi S, Ogawa Y: Effects of pentoxifylline on flap survival . Plast Reconstr Surg 1980;65:763-767.Crossref 2. Monteiro DT, Santamore WP, Nemir P: The influence of pentoxifylline on skin-flap survival . Plast Reconstr Surg 1986;77:277-281.Crossref 3. Naide D: Drug therapy for peripheral arterial disease . Am Fam Physician 1986;34:215-217. 4. Stefanovich V: Effect of pentoxifylline on energy-rich phosphates in rats' erythrocytes . Res Commun Chem Pathol Pharmacol 1975;10:747-750. 5. Ehrly AM: Improvement of the flow properties of blood: A new therapeutical approach in occlusive arterial disease . Angiology 1976;27:188-196.Crossref 6. Earle AS, Fratianne RB, Nunez FD: The relationship of hematocrit levels to skin flap survival in the dog . Plast Recontr Surg 1974; 54:341-344.Crossref 7. Poggesi L, Scarti L, Boddi M, et al: Pentoxifylline treatment in patients with occlusive peripheral arterial disease: Circulatory changes and effects on prostaglandin synthesis . Angiology 1985;36:628-637.Crossref 8. Manrique RV, Manrique V: Platelet resistance to prostacyclin: Enhancement of the antiaggregatory effect of prostacyclin by pentoxifylline . Angiology 1987;38:101-108.Crossref 9. Schroer RH: Antithrombotic potential of pentoxifylline: A hemorrheologically active drug . Angiology 1985;36:387-398.Crossref 10. Donovan WE: Experimental models in skin flap research , in Grabb WC, Myers MB (eds): Skin Flaps . Boston, Little Brown & Co Inc, 1975, pp 16-18. 11. Baran NK, Horton CE: Growth of skin grafts, flaps, and scars in young minipigs . Plast Reconstr Surg 1972;50:487-496.Crossref 12. Kernahan DA, Zingg W, Kay CW: The effect of hyperbaric oxygen on the survival of experimental skin flaps . Plast Reconstr Surg 1965;36:19-25.Crossref 13. Myers MB, Cherry G: Causes of necrosis in pedicle flaps . Plast Reconstr Surg 1968;42:43-50.Crossref 14. Kerrigan CL, Daniel RK: Skin flap research: A candid review . Ann Plast Surg 1984;18:383-387.Crossref 15. Im MJ, Chi-Tsung S, Hoopes JE: Skin flap metabolism in rats: Oxygen consumption and lactate production . Plast Reconstr Surg 1983; 71:685-688.Crossref 16. Reinisch JF: The pathophysiology of skin flap circulation: The delay phenomenon . Plast Reconstr Surg 1974;54:585-598.Crossref 17. Finseth F, Adelberg MG: Prevention of skin flap necrosis by a course of treatment with vasodilator drugs . Plast Reconstr Surg 1978;61:738-743.Crossref 18. Rohrich RJ, Cherry G, Spira M: Enhancement of skin flap survival using nitroglycerin ointment . Plast Reconstr Surg 1984;73:943-948.Crossref 19. Emerson DJM, Sykes PJ: The effect of prostacyclin on experimental random pattern flaps in the rat . Br J Plast Surg 1981;34:264-266.Crossref 20. Chowardy RP, Berkover AS, Moss ML, et al: Fluorocarbon enhancement of skin flap survival in rats . Plast Reconstr Surg 1987;79:98-101.Crossref 21. Hodgson RS, Brummett RE, Cook TA: Effects of pentoxifylline on experimental skin flap survival . Arch Otolaryngol Head Neck Surg 1987;113:950-952.Crossref 22. Physicians' Desk Reference , ed 42. Oradell, NJ, Medical Books, 1988, pp 1055-1056. 23. Gates GA, Garner E: Effects of pentoxifylline on experimental skin flap survival . Arch Otolaryngol Head Neck Surg 1988;114:681.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

The Effects of Pentoxifylline on Random Skin Flap Survival

Download PDF
3 pages

Loading next page...
 
/lp/american-medical-association/the-effects-of-pentoxifylline-on-random-skin-flap-survival-cYx706VZjQ

References (22)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1989.01860260053013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Random skin flaps are an important and frequently used technique in head and neck reconstruction. Pentoxifylline has been shown to improve the deformability of red blood cells by increasing their intracellular adenosine triphosphate content and, therefore, improving their flow properties. This is especially important in ischemia and low blood flow states present in the distal portions of random skin flaps. The rheologic properties of pentoxifylline were studied in the swine model. Swine in group I (eight flaps) served as controls with no pharmacologic manipulations. Swine in group II (16 flaps) received pentoxifylline (20 mg/kg/d) for ten days preoperatively and ten days postoperatively. Necrosis in swine in group I (controls) averaged 32.6%, which substantiated previous reports. Necrosis in swine in group II (pentoxifylline) averaged 2.57%. This study has shown a statistically significant enhancement of random skin flap survival using pentoxifylline in a swine model. (Arch Otolaryngol Head Neck Surg 1989;115:179-181) References 1. Takayanagi S, Ogawa Y: Effects of pentoxifylline on flap survival . Plast Reconstr Surg 1980;65:763-767.Crossref 2. Monteiro DT, Santamore WP, Nemir P: The influence of pentoxifylline on skin-flap survival . Plast Reconstr Surg 1986;77:277-281.Crossref 3. Naide D: Drug therapy for peripheral arterial disease . Am Fam Physician 1986;34:215-217. 4. Stefanovich V: Effect of pentoxifylline on energy-rich phosphates in rats' erythrocytes . Res Commun Chem Pathol Pharmacol 1975;10:747-750. 5. Ehrly AM: Improvement of the flow properties of blood: A new therapeutical approach in occlusive arterial disease . Angiology 1976;27:188-196.Crossref 6. Earle AS, Fratianne RB, Nunez FD: The relationship of hematocrit levels to skin flap survival in the dog . Plast Recontr Surg 1974; 54:341-344.Crossref 7. Poggesi L, Scarti L, Boddi M, et al: Pentoxifylline treatment in patients with occlusive peripheral arterial disease: Circulatory changes and effects on prostaglandin synthesis . Angiology 1985;36:628-637.Crossref 8. Manrique RV, Manrique V: Platelet resistance to prostacyclin: Enhancement of the antiaggregatory effect of prostacyclin by pentoxifylline . Angiology 1987;38:101-108.Crossref 9. Schroer RH: Antithrombotic potential of pentoxifylline: A hemorrheologically active drug . Angiology 1985;36:387-398.Crossref 10. Donovan WE: Experimental models in skin flap research , in Grabb WC, Myers MB (eds): Skin Flaps . Boston, Little Brown & Co Inc, 1975, pp 16-18. 11. Baran NK, Horton CE: Growth of skin grafts, flaps, and scars in young minipigs . Plast Reconstr Surg 1972;50:487-496.Crossref 12. Kernahan DA, Zingg W, Kay CW: The effect of hyperbaric oxygen on the survival of experimental skin flaps . Plast Reconstr Surg 1965;36:19-25.Crossref 13. Myers MB, Cherry G: Causes of necrosis in pedicle flaps . Plast Reconstr Surg 1968;42:43-50.Crossref 14. Kerrigan CL, Daniel RK: Skin flap research: A candid review . Ann Plast Surg 1984;18:383-387.Crossref 15. Im MJ, Chi-Tsung S, Hoopes JE: Skin flap metabolism in rats: Oxygen consumption and lactate production . Plast Reconstr Surg 1983; 71:685-688.Crossref 16. Reinisch JF: The pathophysiology of skin flap circulation: The delay phenomenon . Plast Reconstr Surg 1974;54:585-598.Crossref 17. Finseth F, Adelberg MG: Prevention of skin flap necrosis by a course of treatment with vasodilator drugs . Plast Reconstr Surg 1978;61:738-743.Crossref 18. Rohrich RJ, Cherry G, Spira M: Enhancement of skin flap survival using nitroglycerin ointment . Plast Reconstr Surg 1984;73:943-948.Crossref 19. Emerson DJM, Sykes PJ: The effect of prostacyclin on experimental random pattern flaps in the rat . Br J Plast Surg 1981;34:264-266.Crossref 20. Chowardy RP, Berkover AS, Moss ML, et al: Fluorocarbon enhancement of skin flap survival in rats . Plast Reconstr Surg 1987;79:98-101.Crossref 21. Hodgson RS, Brummett RE, Cook TA: Effects of pentoxifylline on experimental skin flap survival . Arch Otolaryngol Head Neck Surg 1987;113:950-952.Crossref 22. Physicians' Desk Reference , ed 42. Oradell, NJ, Medical Books, 1988, pp 1055-1056. 23. Gates GA, Garner E: Effects of pentoxifylline on experimental skin flap survival . Arch Otolaryngol Head Neck Surg 1988;114:681.Crossref

Journal

Archives of Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Feb 1, 1989

There are no references for this article.