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In Vivo Model for the Evaluation of Topical Antiallergic Medications

In Vivo Model for the Evaluation of Topical Antiallergic Medications Abstract • A novel human in vivo model of intranasal challenge with antigen is used to demonstrate the effectiveness of a topical antirelease drug. Previous experimentation has established a highly significant correlation between the physiologic response of sneezing, which occurs after insufflation of antigen into the nose of allergic individuals, and the recovery of putative mast cell mediators: histamine, tosyl arginine methyl ester (TAME)–esterase(s), and prostaglandin D2. Azatadine base, a tricyclic antihistamine, which also inhibits mediator release in vitro, applied prior to antigen administration not only reduces the clinical symptom of sneezing but simultaneously reduces the concentration of the inflammatory mediator, TAME-esterase(s), recovered from nasal washes. To our knowledge, this is the first observation that an antirelease drug can stop mediator release in vivo in the nose. (Arch Otolaryngol 1984;110:25-27) References 1. Mygind N: The immune system , in Mygind N (ed): Nasal Allergy . Oxford, England, Black-well Scientific Publications, 1978, pp 77-78. 2. Naclerio RM, Meier HL, Kagey-Sobotka A, et al: Mediator release after nasal airway challenge with allergen . Am Rev Respir Dis , in press. 3. Lichtenstein LM, Foreman JC, Conroy MC, et al: Differences between histamine release from rat mast cells and human basophils and mast cells , in Pepys J, Edwards AM (eds): The Mast Cell: Its Role in Health and Disease . Kent, England, Pitman Medical Publishing Co Ltd, 1979, pp 83-96. 4. Lichtenstein LM, Gillespie E: The effects of the H, and H, antihistamines on "allergic" histamine release and its inhibition by histamine . J Pharmacol Exp Ther 1975;192:441-450. 5. Newball HH, Talamo RC, Lichtenstein LM: Anaphylactic release of a basophil kallikrein-like activity: II. A mediator of immediate hypersensitivity reactions . J Clin Invest 1979;64:466-475.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

In Vivo Model for the Evaluation of Topical Antiallergic Medications

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1984.00800270029008
Publisher site
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Abstract

Abstract • A novel human in vivo model of intranasal challenge with antigen is used to demonstrate the effectiveness of a topical antirelease drug. Previous experimentation has established a highly significant correlation between the physiologic response of sneezing, which occurs after insufflation of antigen into the nose of allergic individuals, and the recovery of putative mast cell mediators: histamine, tosyl arginine methyl ester (TAME)–esterase(s), and prostaglandin D2. Azatadine base, a tricyclic antihistamine, which also inhibits mediator release in vitro, applied prior to antigen administration not only reduces the clinical symptom of sneezing but simultaneously reduces the concentration of the inflammatory mediator, TAME-esterase(s), recovered from nasal washes. To our knowledge, this is the first observation that an antirelease drug can stop mediator release in vivo in the nose. (Arch Otolaryngol 1984;110:25-27) References 1. Mygind N: The immune system , in Mygind N (ed): Nasal Allergy . Oxford, England, Black-well Scientific Publications, 1978, pp 77-78. 2. Naclerio RM, Meier HL, Kagey-Sobotka A, et al: Mediator release after nasal airway challenge with allergen . Am Rev Respir Dis , in press. 3. Lichtenstein LM, Foreman JC, Conroy MC, et al: Differences between histamine release from rat mast cells and human basophils and mast cells , in Pepys J, Edwards AM (eds): The Mast Cell: Its Role in Health and Disease . Kent, England, Pitman Medical Publishing Co Ltd, 1979, pp 83-96. 4. Lichtenstein LM, Gillespie E: The effects of the H, and H, antihistamines on "allergic" histamine release and its inhibition by histamine . J Pharmacol Exp Ther 1975;192:441-450. 5. Newball HH, Talamo RC, Lichtenstein LM: Anaphylactic release of a basophil kallikrein-like activity: II. A mediator of immediate hypersensitivity reactions . J Clin Invest 1979;64:466-475.Crossref

Journal

Archives of Otolaryngology – American Medical Association

Published: Jan 1, 1984

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