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The Controversial Role of BCG in the Treatment of Squamous Cell Carcinoma of the Head and Neck

The Controversial Role of BCG in the Treatment of Squamous Cell Carcinoma of the Head and Neck Abstract In the last two decades, the technological progress in surgery and anesthesia, and in particular the skills and dedication of several head and neck surgeons, and radiotherapists, have made it possible to achieve local-regional control of disease in the majority of patients with carcinoma of the head and neck. In a series of patients with advanced carcinomas of the pyriform sinus reported in 1979 by Byers et al,1 from the M. D. Anderson Hospital in Houston, disease above the clavicles was controlled in as many as 81% of the patients. These results were obtained with the use of surgery and postoperative radiation therapy. Mesic et al,2 from the same institution, have recently reported their results in the treatment of lymphoepitheliomas of the nasopharynx with megalovoltage irradiation. The disease was successfully controlled above the clavicles in more than 90% of cases with advanced local (T3-T4) and cervical nodal (N2-N3) References 1. Byers RM, Krueger Wesley WO, Saxton J: Use of surgery and postoperative radiation in the treatment of advanced squamous cell carcinoma of the pyriform sinus . Am J Surg 1979;138:597-599.Crossref 2. Mesic JB, Fletcher GH, Goepfert H: Megavoltage irradiation of epithelial tumors of the nasopharynx . Int J Radiat Oncol Biol Phys 1981;7:447-453.Crossref 3. Donaldson RC: Methotrexate plus bacillus Calmette-Guerin (BCG) and isoniazid in the treatment of cancer of the head and neck . Am J Surg 1972;124:527-534.Crossref 4. Richman SP, Livingston RS, Gutterman JU, et al: Chemotherapy versus chemoimmunotherapy of head and neck cancer: Report of a randomized study . Cancer Treat Rep 1976;60:535-539. 5. Suen JY, Richman SP, Livingston RB, et al: Results of BCG adjuvant immunotherapy in 100 patients with epidermoid carcinoma of the head and neck . Am J Surg 1977;134:474-478.Crossref 6. Woods JE, DeSanto LW, Ritts RE: A controlled study of combined methotrexate, BCG, and INH therapy for squamous cell carcinoma of the head and neck . Surg Clin North Am 1977;57:769-778. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

The Controversial Role of BCG in the Treatment of Squamous Cell Carcinoma of the Head and Neck

MEDINA, JESUS E.
Archives of Otolaryngology , Volume 109 (8) – Aug 1, 1983
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The Controversial Role of BCG in the Treatment of Squamous Cell Carcinoma of the Head and Neck

Abstract

Abstract In the last two decades, the technological progress in surgery and anesthesia, and in particular the skills and dedication of several head and neck surgeons, and radiotherapists, have made it possible to achieve local-regional control of disease in the majority of patients with carcinoma of the head and neck. In a series of patients with advanced carcinomas of the pyriform sinus reported in 1979 by Byers et al,1 from the M. D. Anderson Hospital in Houston, disease above the clavicles...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1983.00800220049012
Publisher site
See Article on Publisher Site

Abstract

Abstract In the last two decades, the technological progress in surgery and anesthesia, and in particular the skills and dedication of several head and neck surgeons, and radiotherapists, have made it possible to achieve local-regional control of disease in the majority of patients with carcinoma of the head and neck. In a series of patients with advanced carcinomas of the pyriform sinus reported in 1979 by Byers et al,1 from the M. D. Anderson Hospital in Houston, disease above the clavicles was controlled in as many as 81% of the patients. These results were obtained with the use of surgery and postoperative radiation therapy. Mesic et al,2 from the same institution, have recently reported their results in the treatment of lymphoepitheliomas of the nasopharynx with megalovoltage irradiation. The disease was successfully controlled above the clavicles in more than 90% of cases with advanced local (T3-T4) and cervical nodal (N2-N3) References 1. Byers RM, Krueger Wesley WO, Saxton J: Use of surgery and postoperative radiation in the treatment of advanced squamous cell carcinoma of the pyriform sinus . Am J Surg 1979;138:597-599.Crossref 2. Mesic JB, Fletcher GH, Goepfert H: Megavoltage irradiation of epithelial tumors of the nasopharynx . Int J Radiat Oncol Biol Phys 1981;7:447-453.Crossref 3. Donaldson RC: Methotrexate plus bacillus Calmette-Guerin (BCG) and isoniazid in the treatment of cancer of the head and neck . Am J Surg 1972;124:527-534.Crossref 4. Richman SP, Livingston RS, Gutterman JU, et al: Chemotherapy versus chemoimmunotherapy of head and neck cancer: Report of a randomized study . Cancer Treat Rep 1976;60:535-539. 5. Suen JY, Richman SP, Livingston RB, et al: Results of BCG adjuvant immunotherapy in 100 patients with epidermoid carcinoma of the head and neck . Am J Surg 1977;134:474-478.Crossref 6. Woods JE, DeSanto LW, Ritts RE: A controlled study of combined methotrexate, BCG, and INH therapy for squamous cell carcinoma of the head and neck . Surg Clin North Am 1977;57:769-778.

Journal

Archives of Otolaryngology – American Medical Association

Published: Aug 1, 1983

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