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Ectopic Parathyroid Hormone Production by a Squamous Carcinoma of the Tonsil

Ectopic Parathyroid Hormone Production by a Squamous Carcinoma of the Tonsil Abstract • A patient with recurrent squamous carcinoma of the neck showed hypercalcemia with the immunoreactive parathyroid hormone (PTH) level within the upper limits of normal range, this being inappropriate for the degree of hypercalcemia. An immunoreactive peak of PTH was found in the tumor tissue extract, which appeared on column chromatography to be in the region of elution of pure bovine PTH. The tumor tissue showed positive immunoperoxidase reaction for PTH compared with negative reaction when the patient had normocalcemia. These findings are strong evidence that the tumor produced a PTHlike substance. (Arch Otolaryngol 1983;109:91-94) References 1. Omenn GS: Ectopic polypeptide hormone production by tumors . Ann Intern Med 1970; 72:136-138.Crossref 2. Lafferty FW: Pseudohyperparathyroidism . Medicine 1966;45:247-260.Crossref 3. Liddle GW, Nicholson WE, Island DP, et al: Clinical and laboratory studies of ectopic humoral syndrome . Recent Prog Horm Res 1969;25:283-314. 4. Riggs BL, Arnaud CD, Reynolds JC, et al: Immunological differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer . J Clin Invest 1971; 50:2079-2083.Crossref 5. Samaan NA, Hickey RC, Hill CS Jr, et al: Parathyroid tumors: Preoperative localization and their association with other tumors . Cancer 1974;33:933-939.Crossref 6. Samaan NA, Hickey RC, Sethi MR, et al: Hypercalcemia in patients with known malignant disease . Surgery 1976;80:382-389. 7. Tashjian AH Jr, Voelkel EF, Goldhaber P, et al: Prostaglandins and calcium metabolism in cancer . Fed Prod Fed Am Soc Exp Biol 1974; 33:81-86. 8. Seyberth HW, Segre GV, Morgan JL, et al: Prostaglandins as mediators of hypercalcemia associated with certain types of cancer . N Engl J Med 1975;293:1278-1283.Crossref 9. Luben RA, Mundy GR, Trummel CL, et al: Partial purification of osteoclast-activating factor from phytohemagglutinin-stimulating human leukocytes . J Clin Invest 1974;53:1473-1480.Crossref 10. Mundy GR, Luben RA, Raisz LG, et al: Bone-resorbing activity in supernatants from lymphoid cell lines . N Engl J Med 1974;290:867-871.Crossref 11. Powell D, Singer FR, Murray TM, et al: Non-parathyroid humoral hypercalcemia in patients with neoplastic disease . N Engl J Med 1973;289:176-181.Crossref 12. Stewart AF, Horst R, Deftoi LJ, et al: A 1980 biochemical evaluation of patients with cancer-associated hypercalcemia . N Engl J Med 1980;303:1377-1383.Crossref 13. Arnaud CD, Tsao HS, Oldham SB: Native human parathyroid hormone: An immunochemical investigation . Proc Natl Acad Sci USA 1970; 67:415-422.Crossref 14. Woo J, Singer FR: Radioimmunoassay for human parathyroid hormone . Clin Chim Acta 1974;54:161-168.Crossref 15. Munson TL, Tashjian AH Jr, Levine L: Evidence of parathyroid hormone in non-parathyroid tumors associated with hypercalcemia . Cancer Res 1965;25:1062-1067. 16. Sherwood LM, O'Riordan JLH, Aurbach GD, et al: Production of parathyroid hormone by non-parathyroid tumors . J Clin Endocrinol Metabol 1967;27:140-146.Crossref 17. Knill-Jones RP, Buckle RM, Parson V, et al: Hypercalcemia and increased parathyroidhormone activity in a primary hepatoma: Studies before and after hepatic transplantation . N Engl J Med 1970;282:704-708.Crossref 18. Palmieri GMA, Norquist RE, Omenn GS: Immunochemical localization of parathyroid hormone in cancer tissue from patients with ectopic hyperparathyroidism . J Clin Invest 1976; 53:1726-1735.Crossref 19. Deftos LJ, McMillan PJ, Sartiano GP, et al: Simultaneous ectopic production of parathyroid hormone and calcitonin . Metabolism 1976;25:543-550.Crossref 20. Benson RC, Riggs BL, Pickard BM, et al: Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease . Am J Med 1974;56:821-826.Crossref 21. Benson RC, Riggs BL, Pickard BM, et al: Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism . J Clin Invest 1974;54:175-181.Crossref 22. Hartman CR, MacGregor RR, Chu LLH, et al: Evidence for the biosynthesis of PTH-like peptides by a human squamous cell carcinoma in: Abstracts of the Endocrine Society, 57th Meeting. New York, Endocrine Society, No. 2, 1975. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Ectopic Parathyroid Hormone Production by a Squamous Carcinoma of the Tonsil

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1983.00800160025006
Publisher site
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Abstract

Abstract • A patient with recurrent squamous carcinoma of the neck showed hypercalcemia with the immunoreactive parathyroid hormone (PTH) level within the upper limits of normal range, this being inappropriate for the degree of hypercalcemia. An immunoreactive peak of PTH was found in the tumor tissue extract, which appeared on column chromatography to be in the region of elution of pure bovine PTH. The tumor tissue showed positive immunoperoxidase reaction for PTH compared with negative reaction when the patient had normocalcemia. These findings are strong evidence that the tumor produced a PTHlike substance. (Arch Otolaryngol 1983;109:91-94) References 1. Omenn GS: Ectopic polypeptide hormone production by tumors . Ann Intern Med 1970; 72:136-138.Crossref 2. Lafferty FW: Pseudohyperparathyroidism . Medicine 1966;45:247-260.Crossref 3. Liddle GW, Nicholson WE, Island DP, et al: Clinical and laboratory studies of ectopic humoral syndrome . Recent Prog Horm Res 1969;25:283-314. 4. Riggs BL, Arnaud CD, Reynolds JC, et al: Immunological differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer . J Clin Invest 1971; 50:2079-2083.Crossref 5. Samaan NA, Hickey RC, Hill CS Jr, et al: Parathyroid tumors: Preoperative localization and their association with other tumors . Cancer 1974;33:933-939.Crossref 6. Samaan NA, Hickey RC, Sethi MR, et al: Hypercalcemia in patients with known malignant disease . Surgery 1976;80:382-389. 7. Tashjian AH Jr, Voelkel EF, Goldhaber P, et al: Prostaglandins and calcium metabolism in cancer . Fed Prod Fed Am Soc Exp Biol 1974; 33:81-86. 8. Seyberth HW, Segre GV, Morgan JL, et al: Prostaglandins as mediators of hypercalcemia associated with certain types of cancer . N Engl J Med 1975;293:1278-1283.Crossref 9. Luben RA, Mundy GR, Trummel CL, et al: Partial purification of osteoclast-activating factor from phytohemagglutinin-stimulating human leukocytes . J Clin Invest 1974;53:1473-1480.Crossref 10. Mundy GR, Luben RA, Raisz LG, et al: Bone-resorbing activity in supernatants from lymphoid cell lines . N Engl J Med 1974;290:867-871.Crossref 11. Powell D, Singer FR, Murray TM, et al: Non-parathyroid humoral hypercalcemia in patients with neoplastic disease . N Engl J Med 1973;289:176-181.Crossref 12. Stewart AF, Horst R, Deftoi LJ, et al: A 1980 biochemical evaluation of patients with cancer-associated hypercalcemia . N Engl J Med 1980;303:1377-1383.Crossref 13. Arnaud CD, Tsao HS, Oldham SB: Native human parathyroid hormone: An immunochemical investigation . Proc Natl Acad Sci USA 1970; 67:415-422.Crossref 14. Woo J, Singer FR: Radioimmunoassay for human parathyroid hormone . Clin Chim Acta 1974;54:161-168.Crossref 15. Munson TL, Tashjian AH Jr, Levine L: Evidence of parathyroid hormone in non-parathyroid tumors associated with hypercalcemia . Cancer Res 1965;25:1062-1067. 16. Sherwood LM, O'Riordan JLH, Aurbach GD, et al: Production of parathyroid hormone by non-parathyroid tumors . J Clin Endocrinol Metabol 1967;27:140-146.Crossref 17. Knill-Jones RP, Buckle RM, Parson V, et al: Hypercalcemia and increased parathyroidhormone activity in a primary hepatoma: Studies before and after hepatic transplantation . N Engl J Med 1970;282:704-708.Crossref 18. Palmieri GMA, Norquist RE, Omenn GS: Immunochemical localization of parathyroid hormone in cancer tissue from patients with ectopic hyperparathyroidism . J Clin Invest 1976; 53:1726-1735.Crossref 19. Deftos LJ, McMillan PJ, Sartiano GP, et al: Simultaneous ectopic production of parathyroid hormone and calcitonin . Metabolism 1976;25:543-550.Crossref 20. Benson RC, Riggs BL, Pickard BM, et al: Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease . Am J Med 1974;56:821-826.Crossref 21. Benson RC, Riggs BL, Pickard BM, et al: Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism . J Clin Invest 1974;54:175-181.Crossref 22. Hartman CR, MacGregor RR, Chu LLH, et al: Evidence for the biosynthesis of PTH-like peptides by a human squamous cell carcinoma in: Abstracts of the Endocrine Society, 57th Meeting. New York, Endocrine Society, No. 2, 1975.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Feb 1, 1983

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