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Acquired Subglottic Stenosis Following Prolonged Endotracheal Intubation: A Canine Model

Acquired Subglottic Stenosis Following Prolonged Endotracheal Intubation: A Canine Model Abstract • We developed a canine animal model of subglottic stenosis following prolonged intubation with modified noncuffed endotracheal tubes. None of the puppies intubated for seven days had an irreversible stenosing subglottic lesion, whereas all animals intubated for 14 days or more had at least a 40% to 50% reduction of the subglottic lumen secondary to maturing fibrotic stenosis. The model described is more congruent with the known and suspected pathogenesis in those infants and children who require prolonged endotracheal intubation and subsequently acquire subglottic stenosis, and can be used in evaluating the efficacy of medical therapy or surgical therapy, or both, in the prevention or management of this disease. (Arch Otolaryngol 1982;108:727-731) References 1. Marshak G, Grundfast KM: Subglottic stenosis. Pediatr Clin North Am 1981;28:941-948. 2. Guess WL, Stetson JB: Tissue toxicity from rubber endotracheal tubes . Int Anesthesiol Clin 1970;8:823-828.Crossref 3. Stetson JB, Guess WL: Causes of damage to tissues by polymers and elastomers used in the fabrication of tracheal devices . Anesthesiology 1970;33:635-652.Crossref 4. Fearon B, MacDonald RE, Smith C, et al: Airway problems in children following prolonged endotracheal intubation . Ann Otol Rhinol Laryngol 1966;75:975-986. 5. Strong RM, Passy V: Endotracheal intubation: Complications in neonates . Arch Otolaryngol 1977;103:329-335.Crossref 6. Bryce DP, Briant TDR, Pearson FG: Laryngeal and tracheal complications of intubation . Ann Otol Rhinol Laryngol 1968;77:442-461. 7. Borowiecki B, Croft CB: Experimental animal model of subglottic stenosis . Ann Otol Rhinol Laryngol 1977;86:835-840. 8. McGee KC, Nagle JW, Toohill RJ: CO2 laser repair of subglottic and upper tracheal stenosis . Otolaryngol Head Neck Surg 1981;89:92-95. 9. Rice DH, Colman M: Repair of subglottic stenosis with a free perichondrial graft . Arch Otolaryngol 1982;108:25-27.Crossref 10. Marshak G, Doyle WJ, Bluestone CD: Canine model of subglottic stenosis secondary to prolonged endotracheal intubation . Laryngoscope 1982;92:805-809.Crossref 11. Miles WK: Tubeless canine tracheostomy for laryngeal experimentation . Arch Otolaryngol 1970;92:124-127.Crossref 12. Sasaki CT, Horiuchi M, Koss N: Tracheostomy-related subglottic stenosis: Bacteriologic pathogenesis . Laryngoscope 1979;89:857-865. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Acquired Subglottic Stenosis Following Prolonged Endotracheal Intubation: A Canine Model

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1982.00790590049014
Publisher site
See Article on Publisher Site

Abstract

Abstract • We developed a canine animal model of subglottic stenosis following prolonged intubation with modified noncuffed endotracheal tubes. None of the puppies intubated for seven days had an irreversible stenosing subglottic lesion, whereas all animals intubated for 14 days or more had at least a 40% to 50% reduction of the subglottic lumen secondary to maturing fibrotic stenosis. The model described is more congruent with the known and suspected pathogenesis in those infants and children who require prolonged endotracheal intubation and subsequently acquire subglottic stenosis, and can be used in evaluating the efficacy of medical therapy or surgical therapy, or both, in the prevention or management of this disease. (Arch Otolaryngol 1982;108:727-731) References 1. Marshak G, Grundfast KM: Subglottic stenosis. Pediatr Clin North Am 1981;28:941-948. 2. Guess WL, Stetson JB: Tissue toxicity from rubber endotracheal tubes . Int Anesthesiol Clin 1970;8:823-828.Crossref 3. Stetson JB, Guess WL: Causes of damage to tissues by polymers and elastomers used in the fabrication of tracheal devices . Anesthesiology 1970;33:635-652.Crossref 4. Fearon B, MacDonald RE, Smith C, et al: Airway problems in children following prolonged endotracheal intubation . Ann Otol Rhinol Laryngol 1966;75:975-986. 5. Strong RM, Passy V: Endotracheal intubation: Complications in neonates . Arch Otolaryngol 1977;103:329-335.Crossref 6. Bryce DP, Briant TDR, Pearson FG: Laryngeal and tracheal complications of intubation . Ann Otol Rhinol Laryngol 1968;77:442-461. 7. Borowiecki B, Croft CB: Experimental animal model of subglottic stenosis . Ann Otol Rhinol Laryngol 1977;86:835-840. 8. McGee KC, Nagle JW, Toohill RJ: CO2 laser repair of subglottic and upper tracheal stenosis . Otolaryngol Head Neck Surg 1981;89:92-95. 9. Rice DH, Colman M: Repair of subglottic stenosis with a free perichondrial graft . Arch Otolaryngol 1982;108:25-27.Crossref 10. Marshak G, Doyle WJ, Bluestone CD: Canine model of subglottic stenosis secondary to prolonged endotracheal intubation . Laryngoscope 1982;92:805-809.Crossref 11. Miles WK: Tubeless canine tracheostomy for laryngeal experimentation . Arch Otolaryngol 1970;92:124-127.Crossref 12. Sasaki CT, Horiuchi M, Koss N: Tracheostomy-related subglottic stenosis: Bacteriologic pathogenesis . Laryngoscope 1979;89:857-865.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Nov 1, 1982

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