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Low-Dose Topical Atropine for Rhinorrhea

Low-Dose Topical Atropine for Rhinorrhea Abstract • One hundred years ago, atropine sulfate was commonly used to treat rhinorrhea. Atropine sulfate was applied topically at a dose of approximately 0.08 mg to each nostril in seven patients with rhinorrhea caused by allergic rhinitis and in 24 patients with rhinorrhea caused by viral rhinitis. All but one of the 31 patients had symptomatic relief. Twenty-four of the 31 patients showed a visible decrease in secretions, and three patients showed an obvious vasoconstriction of nasal blood vessels. None of the patients experienced any of the side effects of atropine. Since this was a one-dose pilot study, there are no data available on possible rebound or chemical rhinitis effects. (Arch Otolaryngol 1981;107:288-289) References 1. Sajous CE: Lectures on the Diseases of the Nose and Throat . Philadelphia, FA Davis Co, 1885, p 415. 2. Burnett C, Ingals EF, Newcomb JE: Textbook on Diseases of the Ear, Nose and Throat . Philadelphia, JB Lippincott Co, 1901, p 257. 3. Robinson B: A Practical Treatise on Nasal Catarrh and Allied Diseases . New York, William Wood, 1885, p 56. 4. Robinson B: A Practical Treatise on Nasal Catarrh and Allied Diseases . New York, William Wood, 1880, p 61. 5. Ballenger WL: Diseases of the Nose, Throat and Ear: Medical and Surgical . Philadelphia, Lea & Febiger, 1909, p 136. 6. Price-Brown J: Diseases of the Nose and Throat . Philadelphia, FA Davis Co, 1900, p 102. 7. Richards GL: Nose and Throat Work for the General Practitioner . New York, International Journal of Surgery, 1903, p 239. 8. Reik HO: Diseases of the Ear, Nose and Throat . New York, D Appleton, 1911, p 277. 9. AMA Drug Evaluations , ed 4. New York, John Wiley & Sons Inc, 1980, pp 463-466. 10. Davis WB: The prevention and treatment of the common cold in children . Arch Pediatr 1929;46:172-175. 11. Diehl HS: Medicinal treatment of the common cold . JAMA 1933;101:2042-2049.Crossref 12. Lord FT: Certain aspects of the common cold . Med Clin North Am 1936;19:1499-1504. 13. Sollman T: A Manual of Pharmacology and its Applications to Therapeutics and Toxicology , ed 8. Philadelphia, WB Saunders Co, 1957, p 387. 14. Salter W: A Textbook of Pharmacology . Philadelphia, WB Saunders Co, 1952. 15. Eccles R, Wilson H: The autonomic innervation of the nasal blood vessels of the cat . J Physiol 1974;238:549-560. 16. Malm L: Physiological and pharmacological studies of the cat's nasal vessels . Acta Otolaryngol 1973;73:277-282.Crossref 17. Anggard A: The effects of parasympathetic nerve stimulation on the microcirculation and secretion in the nasal mucosa of the cat . Acta Otolaryngol 1974;78:98-105.Crossref 18. Gadlage R, Behnke EE, Jackson RT: Is the Vidian nerve cholinergic? Arch Otolaryngol 1975;101:422-425.Crossref 19. Malcomson KG: The vasomotor activities of the nasal mucous membrane . J Laryngol Otol 1959;73:73-98.Crossref 20. Mitchell GAG: The automatic nerve supply of the throat, nose and ear . J Laryngol Otol 1954;68:505-509.Crossref 21. Jackson RT: Evidence for presynaptic, parasympathetic receptors on nasal blood vessels . Ann Otol Rhinol Laryngol , to be published. 22. Goodman L, Gilman A: The Pharmacological Basis of Therapeutics , ed 3. New York, Macmillan Publishing Co Inc, 1965, p 531. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Low-Dose Topical Atropine for Rhinorrhea

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References (22)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1981.00790410026006
Publisher site
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Abstract

Abstract • One hundred years ago, atropine sulfate was commonly used to treat rhinorrhea. Atropine sulfate was applied topically at a dose of approximately 0.08 mg to each nostril in seven patients with rhinorrhea caused by allergic rhinitis and in 24 patients with rhinorrhea caused by viral rhinitis. All but one of the 31 patients had symptomatic relief. Twenty-four of the 31 patients showed a visible decrease in secretions, and three patients showed an obvious vasoconstriction of nasal blood vessels. None of the patients experienced any of the side effects of atropine. Since this was a one-dose pilot study, there are no data available on possible rebound or chemical rhinitis effects. (Arch Otolaryngol 1981;107:288-289) References 1. Sajous CE: Lectures on the Diseases of the Nose and Throat . Philadelphia, FA Davis Co, 1885, p 415. 2. Burnett C, Ingals EF, Newcomb JE: Textbook on Diseases of the Ear, Nose and Throat . Philadelphia, JB Lippincott Co, 1901, p 257. 3. Robinson B: A Practical Treatise on Nasal Catarrh and Allied Diseases . New York, William Wood, 1885, p 56. 4. Robinson B: A Practical Treatise on Nasal Catarrh and Allied Diseases . New York, William Wood, 1880, p 61. 5. Ballenger WL: Diseases of the Nose, Throat and Ear: Medical and Surgical . Philadelphia, Lea & Febiger, 1909, p 136. 6. Price-Brown J: Diseases of the Nose and Throat . Philadelphia, FA Davis Co, 1900, p 102. 7. Richards GL: Nose and Throat Work for the General Practitioner . New York, International Journal of Surgery, 1903, p 239. 8. Reik HO: Diseases of the Ear, Nose and Throat . New York, D Appleton, 1911, p 277. 9. AMA Drug Evaluations , ed 4. New York, John Wiley & Sons Inc, 1980, pp 463-466. 10. Davis WB: The prevention and treatment of the common cold in children . Arch Pediatr 1929;46:172-175. 11. Diehl HS: Medicinal treatment of the common cold . JAMA 1933;101:2042-2049.Crossref 12. Lord FT: Certain aspects of the common cold . Med Clin North Am 1936;19:1499-1504. 13. Sollman T: A Manual of Pharmacology and its Applications to Therapeutics and Toxicology , ed 8. Philadelphia, WB Saunders Co, 1957, p 387. 14. Salter W: A Textbook of Pharmacology . Philadelphia, WB Saunders Co, 1952. 15. Eccles R, Wilson H: The autonomic innervation of the nasal blood vessels of the cat . J Physiol 1974;238:549-560. 16. Malm L: Physiological and pharmacological studies of the cat's nasal vessels . Acta Otolaryngol 1973;73:277-282.Crossref 17. Anggard A: The effects of parasympathetic nerve stimulation on the microcirculation and secretion in the nasal mucosa of the cat . Acta Otolaryngol 1974;78:98-105.Crossref 18. Gadlage R, Behnke EE, Jackson RT: Is the Vidian nerve cholinergic? Arch Otolaryngol 1975;101:422-425.Crossref 19. Malcomson KG: The vasomotor activities of the nasal mucous membrane . J Laryngol Otol 1959;73:73-98.Crossref 20. Mitchell GAG: The automatic nerve supply of the throat, nose and ear . J Laryngol Otol 1954;68:505-509.Crossref 21. Jackson RT: Evidence for presynaptic, parasympathetic receptors on nasal blood vessels . Ann Otol Rhinol Laryngol , to be published. 22. Goodman L, Gilman A: The Pharmacological Basis of Therapeutics , ed 3. New York, Macmillan Publishing Co Inc, 1965, p 531.

Journal

Archives of Otolaryngology – American Medical Association

Published: May 1, 1981

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