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Inhibition of Experimental Esophageal Lye Strictures by Penicillamine

Inhibition of Experimental Esophageal Lye Strictures by Penicillamine Abstract • We describe a new experimental model for the study of caustic stenosis of the esophagus in the rat. Sixty-five Wistar rats were given a standard esophageal lye burn. Animals were divided into two groups: (1) a control group and (2) a treatment group that received penicillamine from the day after the esophageal lye burn. Stenosis developed in only two of the 23 treated rats. Our conclusion is that penicillamine-induced lathyrism inhibits the onset of stenosis in the rat. Double-blind controlled studies of the effect of penicillamine in the prevention of corrosive strictures of the esophagus in man seem warranted. (Arch Otolaryngol 1981;107:145-147) References 1. Davis MW, Madden JW, Peacock EE Jr: A new approach to the control of esophageal stenosis . Ann Surg 1972;176:469-475.Crossref 2. Nimni ME, Deshmukh K, Gerth N, et al: Changes in collagen metabolism associated with the administration of penicillamine and various amino and thiol compounds . Biochem Pharmacol 1969;18:707-714.Crossref 3. Vogel HG: Effects of D-penicillamine and prednisolone on connective tissue in rats . Connect Tissue Res 1972;1:283-289.Crossref 4. Nimni ME: Abnormality in collagen metabolism penicillamine-treated rats . Arthritis Rheum 1966;9:526-527. 5. Haller JA, Bachman K: The comparative effect of pediatrics current therapy on experimental caustic burn of the esophagus . Pediatrics 1964;34:236-245. 6. Rosenberg N, Kunderman PJ, Vroman L, et al: Prevention of experimental lye strictures of the esophagus by cortisone . Arch Surg 1951;63:147-151.Crossref 7. Bosher LH Jr, Burford TH, Ackerman L: The pathology of experimentally produced lye burns and strictures of the esophagus . J Thorac Surg 1951;21:483-489. 8. Ronald A, McNeill RA, Welbourn RB: Prevention of corrosive strictures of the esophagus in the rat . J Laryngol Otol 1966;80:346-358.Crossref 9. Knox WG, Scott JR, Lintel HA, et al: Bougienage and steroids used singly or in combination in experimental corrosive esophagitis . Ann Surg 1967;166:930-941.Crossref 10. Madden JW, Davis WM, Butler CH, et al: Experimental esophageal lye burns: II. Correcting established strictures with beta-amino-propionitrile and bougienage . Ann Surg 1973;178:277-283.Crossref 11. Butler C, Madden JW, Davis WM, et al: Morphologic aspects of experimental esophageal lye strictures: II. Effects of steroid hormones, bougienage, and induced lathyrism on acute lye burns . Surgery 1977;81:431-435. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Inhibition of Experimental Esophageal Lye Strictures by Penicillamine

Gehanno, Pierre; Guedon, Charles
Archives of Otolaryngology , Volume 107 (3) – Mar 1, 1981
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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1981.00790390011004
Publisher site
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Abstract

Abstract • We describe a new experimental model for the study of caustic stenosis of the esophagus in the rat. Sixty-five Wistar rats were given a standard esophageal lye burn. Animals were divided into two groups: (1) a control group and (2) a treatment group that received penicillamine from the day after the esophageal lye burn. Stenosis developed in only two of the 23 treated rats. Our conclusion is that penicillamine-induced lathyrism inhibits the onset of stenosis in the rat. Double-blind controlled studies of the effect of penicillamine in the prevention of corrosive strictures of the esophagus in man seem warranted. (Arch Otolaryngol 1981;107:145-147) References 1. Davis MW, Madden JW, Peacock EE Jr: A new approach to the control of esophageal stenosis . Ann Surg 1972;176:469-475.Crossref 2. Nimni ME, Deshmukh K, Gerth N, et al: Changes in collagen metabolism associated with the administration of penicillamine and various amino and thiol compounds . Biochem Pharmacol 1969;18:707-714.Crossref 3. Vogel HG: Effects of D-penicillamine and prednisolone on connective tissue in rats . Connect Tissue Res 1972;1:283-289.Crossref 4. Nimni ME: Abnormality in collagen metabolism penicillamine-treated rats . Arthritis Rheum 1966;9:526-527. 5. Haller JA, Bachman K: The comparative effect of pediatrics current therapy on experimental caustic burn of the esophagus . Pediatrics 1964;34:236-245. 6. Rosenberg N, Kunderman PJ, Vroman L, et al: Prevention of experimental lye strictures of the esophagus by cortisone . Arch Surg 1951;63:147-151.Crossref 7. Bosher LH Jr, Burford TH, Ackerman L: The pathology of experimentally produced lye burns and strictures of the esophagus . J Thorac Surg 1951;21:483-489. 8. Ronald A, McNeill RA, Welbourn RB: Prevention of corrosive strictures of the esophagus in the rat . J Laryngol Otol 1966;80:346-358.Crossref 9. Knox WG, Scott JR, Lintel HA, et al: Bougienage and steroids used singly or in combination in experimental corrosive esophagitis . Ann Surg 1967;166:930-941.Crossref 10. Madden JW, Davis WM, Butler CH, et al: Experimental esophageal lye burns: II. Correcting established strictures with beta-amino-propionitrile and bougienage . Ann Surg 1973;178:277-283.Crossref 11. Butler C, Madden JW, Davis WM, et al: Morphologic aspects of experimental esophageal lye strictures: II. Effects of steroid hormones, bougienage, and induced lathyrism on acute lye burns . Surgery 1977;81:431-435.

Journal

Archives of Otolaryngology – American Medical Association

Published: Mar 1, 1981

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