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Squamous Cell Carcinoma of the Soft Palate

Squamous Cell Carcinoma of the Soft Palate Abstract • We performed a retrospective study of 106 patients with carcinoma of the soft palate who were treated at two university hospitals. Computer analysis using a new interactive data base program called MING was made to determine Berkson-Gage survival and Gehan tests of statistical significance. Statistically significant associations with an increased survival included the following: smaller lesions, a clinically negative neck examination, well- and moderately well-differentiated histopathologic features, radiation therapy dose of ≤ 6,300 rads, absence of a simultaneous primary, and surgical salvage. No statistically significant differences were seen with age, sex, stage, or the number of days during which patients were treated with radiation therapy. There appears to be a need for a prospective, multi-institutional, randomized therapy study to solidify treatment policy. Consideration should be given to combine surgery-radiation vs radiation therapy alone. (Arch Otolaryngol 105:710-718, 1979) References 1. Clinical Staging Systems for Cancers of the Head and Neck . Chicago, American Joint Committee for Cancer Staging and End Results Reporting, 1977. 2. Reporting of Cancer Survival and End Results . Chicago, American Joint Committee for Cancer Staging and End Results Reporting. 1963. 3. Brown BW, Hollander M: Statistics: A Biomedical Introduction . New York, John Wiley & Sons, 1977. 4. Bagshaw MA, Doggett RLS, Smith KC, et al: Intra-arterial 5-bromodeoxyuridine and x-ray therapy . Am J Roentgenol Rad Ther Nucl Med 99:886-894, 1967.Crossref 5. Ratzer ER, Schweitzer RJ, Frazell EL: Epidermoid carcinoma of the palate . Am J Surg 119:294-297, 1970.Crossref 6. Russ JW, Applebaum EL, Sisson GA: Squamous cell carcinoma of the soft palate . Laryngoscope 87:1151-1156, 1977.Crossref 7. Seydel HG, Scholl H: Carcinoma of the soft palate and uvula . Am J Roentgenol Rad Ther Nucl Med 120:603-607, 1974.Crossref 8. Fletcher GH, Lindberg RD: Squamous cell carcinomas of the tonsillar area and palatine arch . Am J Roentgenol Rad Ther Nucl Med 96:574-587, 1966.Crossref 9. Konrad HR, Canalis RF, Calcaterra TC: Epidermoid carcinoma of the palate . Arch Otolaryngol 104:208-212, 1978.Crossref 10. Gluckman JL: Synchronous multiple primaries of the upper aerodigestive system. Read before the joint meeting of the American Society for Head and Neck Surgery and the Society of Head and Neck Surgeons, Toronto, May 29, 1978. 11. Martin H: Tumors of the palate (benign and malignant) . Arch Surg 4:599-635, 1942.Crossref 12. Sciarra PA, Locke A Jr, Lehman R: Carcinoma of the palatine arch . ORL Dig , 1974. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Squamous Cell Carcinoma of the Soft Palate

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1979.00790240024006
Publisher site
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Abstract

Abstract • We performed a retrospective study of 106 patients with carcinoma of the soft palate who were treated at two university hospitals. Computer analysis using a new interactive data base program called MING was made to determine Berkson-Gage survival and Gehan tests of statistical significance. Statistically significant associations with an increased survival included the following: smaller lesions, a clinically negative neck examination, well- and moderately well-differentiated histopathologic features, radiation therapy dose of ≤ 6,300 rads, absence of a simultaneous primary, and surgical salvage. No statistically significant differences were seen with age, sex, stage, or the number of days during which patients were treated with radiation therapy. There appears to be a need for a prospective, multi-institutional, randomized therapy study to solidify treatment policy. Consideration should be given to combine surgery-radiation vs radiation therapy alone. (Arch Otolaryngol 105:710-718, 1979) References 1. Clinical Staging Systems for Cancers of the Head and Neck . Chicago, American Joint Committee for Cancer Staging and End Results Reporting, 1977. 2. Reporting of Cancer Survival and End Results . Chicago, American Joint Committee for Cancer Staging and End Results Reporting. 1963. 3. Brown BW, Hollander M: Statistics: A Biomedical Introduction . New York, John Wiley & Sons, 1977. 4. Bagshaw MA, Doggett RLS, Smith KC, et al: Intra-arterial 5-bromodeoxyuridine and x-ray therapy . Am J Roentgenol Rad Ther Nucl Med 99:886-894, 1967.Crossref 5. Ratzer ER, Schweitzer RJ, Frazell EL: Epidermoid carcinoma of the palate . Am J Surg 119:294-297, 1970.Crossref 6. Russ JW, Applebaum EL, Sisson GA: Squamous cell carcinoma of the soft palate . Laryngoscope 87:1151-1156, 1977.Crossref 7. Seydel HG, Scholl H: Carcinoma of the soft palate and uvula . Am J Roentgenol Rad Ther Nucl Med 120:603-607, 1974.Crossref 8. Fletcher GH, Lindberg RD: Squamous cell carcinomas of the tonsillar area and palatine arch . Am J Roentgenol Rad Ther Nucl Med 96:574-587, 1966.Crossref 9. Konrad HR, Canalis RF, Calcaterra TC: Epidermoid carcinoma of the palate . Arch Otolaryngol 104:208-212, 1978.Crossref 10. Gluckman JL: Synchronous multiple primaries of the upper aerodigestive system. Read before the joint meeting of the American Society for Head and Neck Surgery and the Society of Head and Neck Surgeons, Toronto, May 29, 1978. 11. Martin H: Tumors of the palate (benign and malignant) . Arch Surg 4:599-635, 1942.Crossref 12. Sciarra PA, Locke A Jr, Lehman R: Carcinoma of the palatine arch . ORL Dig , 1974.

Journal

Archives of Otolaryngology – American Medical Association

Published: Dec 1, 1979

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