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Giant Calcifying Epithelioma

Giant Calcifying Epithelioma Abstract • Calcifying epithelioma of Malherbe, or benign pilomatrixoma, is described as a skin tumor histologically composed of (1) "shadow" cells, (2) basophilic cells, (3) foreign body cells, and (4) intracellular and stromal calcifications. The dermatologic literature describes this tumor as a small benign lesion that never exhibits a malignant propensity. However, the recent surgical literature associates its enlarged size with its occasional aggressive behavior. In this regard, tumor dimension appears to influence prognosis. The term "giant calcifying epithelioma" appears taxonomically justified as a clinical description of this malignant tumor possessing histologic similarity to benign pilomatrixoma. The surgical literature has not previously stressed the mixed histologic characteristics of this pathologic variant. We report a case that demonstrates the malignant potential of giant calcifying epithelioma. The clinician should be alerted against a false security provided by the benign appearance of preoperative histologic sampling. (Arch Otolaryngol 102:753-755, 1976) References 1. Malherbe A, Chenantais J: Note sur l'epitheliome calcifié des glands sebacées . Prog Med Paris 8:826-828, 1880. 2. Beck SC: Das verkalkte Epitheliome , in Handbuch der Haut und Geschlechtskrankheiten . Berlin, West Germany, Julius Springer, 1933, vol 12, pp 468-473. 3. Turhan B, Krainer L: Bemerkungen uber sogen annten verkalk ended epitheliome der Haut und ihre Genese . Dermatologica 85:73-89, 1942.Crossref 4. McGavran MH: Ultrastructure of pilomatrixoma (calcifying epithelioma) . Cancer 18:1445-1446, 1965.Crossref 5. Holmes EJ: A histochemical test for citralline adaptation of the carbamide diacetyl reaction to histologic sections with positive results in pilomatrixoma (calcifying epitheliomas) . J Histochem Cytochem 16:136-145, 1968.Crossref 6. Moelenbeck FW: Pilomatrixoma (calcifying epithelioma): A statistical study . Arch Dermatol 108:532-536, 1973.Crossref 7. Lever WF: Histopathology of the Skin , ed 5. Philadelphia, JB Lippincott Co, 1975, pp 518-520. 8. Rothman D, Kendall AB, Baldi A: Giant pilomatrixoma (Malherbe calcifying epithelioma) . Arch Surg 111:86-87, 1976.Crossref 9. Krausen AS, Ansel DG, Mays BR: Pilomatrixoma masquerading as a parotid mass . Laryngoscope 84:528-535, 1974.Crossref 10. Urbach F: Geographic pathology of skin cancer , in Biologic Effects of Ultraviolet Radiation . Oxford, England, Pergamon Press Inc, 1969, p 635. 11. Wallace SA, Halpert B: Basal cell carcinoma . Arch Pathol 50:199-208, 1950. 12. Miller D: Cancer of the external auditory meatus . Laryngoscope 65:448-461, 1955.Crossref 13. Schuknecht HF, Carmody CS: Radionecrosis of the temporal bone . Laryngoscope 76:1416-1428, 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Giant Calcifying Epithelioma

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1976.00780170071012
Publisher site
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Abstract

Abstract • Calcifying epithelioma of Malherbe, or benign pilomatrixoma, is described as a skin tumor histologically composed of (1) "shadow" cells, (2) basophilic cells, (3) foreign body cells, and (4) intracellular and stromal calcifications. The dermatologic literature describes this tumor as a small benign lesion that never exhibits a malignant propensity. However, the recent surgical literature associates its enlarged size with its occasional aggressive behavior. In this regard, tumor dimension appears to influence prognosis. The term "giant calcifying epithelioma" appears taxonomically justified as a clinical description of this malignant tumor possessing histologic similarity to benign pilomatrixoma. The surgical literature has not previously stressed the mixed histologic characteristics of this pathologic variant. We report a case that demonstrates the malignant potential of giant calcifying epithelioma. The clinician should be alerted against a false security provided by the benign appearance of preoperative histologic sampling. (Arch Otolaryngol 102:753-755, 1976) References 1. Malherbe A, Chenantais J: Note sur l'epitheliome calcifié des glands sebacées . Prog Med Paris 8:826-828, 1880. 2. Beck SC: Das verkalkte Epitheliome , in Handbuch der Haut und Geschlechtskrankheiten . Berlin, West Germany, Julius Springer, 1933, vol 12, pp 468-473. 3. Turhan B, Krainer L: Bemerkungen uber sogen annten verkalk ended epitheliome der Haut und ihre Genese . Dermatologica 85:73-89, 1942.Crossref 4. McGavran MH: Ultrastructure of pilomatrixoma (calcifying epithelioma) . Cancer 18:1445-1446, 1965.Crossref 5. Holmes EJ: A histochemical test for citralline adaptation of the carbamide diacetyl reaction to histologic sections with positive results in pilomatrixoma (calcifying epitheliomas) . J Histochem Cytochem 16:136-145, 1968.Crossref 6. Moelenbeck FW: Pilomatrixoma (calcifying epithelioma): A statistical study . Arch Dermatol 108:532-536, 1973.Crossref 7. Lever WF: Histopathology of the Skin , ed 5. Philadelphia, JB Lippincott Co, 1975, pp 518-520. 8. Rothman D, Kendall AB, Baldi A: Giant pilomatrixoma (Malherbe calcifying epithelioma) . Arch Surg 111:86-87, 1976.Crossref 9. Krausen AS, Ansel DG, Mays BR: Pilomatrixoma masquerading as a parotid mass . Laryngoscope 84:528-535, 1974.Crossref 10. Urbach F: Geographic pathology of skin cancer , in Biologic Effects of Ultraviolet Radiation . Oxford, England, Pergamon Press Inc, 1969, p 635. 11. Wallace SA, Halpert B: Basal cell carcinoma . Arch Pathol 50:199-208, 1950. 12. Miller D: Cancer of the external auditory meatus . Laryngoscope 65:448-461, 1955.Crossref 13. Schuknecht HF, Carmody CS: Radionecrosis of the temporal bone . Laryngoscope 76:1416-1428, 1966.Crossref

Journal

Archives of Otolaryngology – American Medical Association

Published: Dec 1, 1976

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