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Cephaloridine in Meningitis

Cephaloridine in Meningitis Abstract To the Editor.—I read with interest the report of Newlands1 concerning meningitis after stapedectomy. It is essential that the otologic surgeon be prepared to handle this complication at an early stage to preserve the life of his patient. The use of cephaloridine may not be effective in treating or preventing meningitis, however. An article in a recent issue of the Medical Letter2 based on a consensus of its infectious disease consultants recommends chloramphenicol as the first-choice antibiotic in penicillinallergic individuals with pneumococcal meningitis and states that cephalosporins are not generally recommended for the treatment of this disease. Likewise, a recent review by Moellering and Swartz' emphasizes the poor penetration of cephalosporins into cerebrospinal fluid, representing one of the greatest drawbacks of this class of antibiotics. Fisher et al4 found that only 76% of 72 patients with meningitis responded favorably to cephaloridine, despite intrathecal administration in many cases. References 1. Newlands WJ: Poststapedectomy otitis media and meningitis . Arch Otolaryngol 102:51-56, 1976.Crossref 2. The Medical Letter 18:9-16, (Jan 30) , 1976. 3. Moellering RE Jr, Swartz MN: Drug therapy: The newer cephalosporins . N Engl J Med 294:24-28, 1976.Crossref 4. Fisher LS, Chow AW, Yoshikawa TT, et al: Cephalothin and cephaloridine therapy for bacterial meningitis: An evaluation . Ann Intern Med 82:689-693, 1975.Crossref 5. Mangi RJ, Kundargi RS, Quintiliani R, et al: Development of meningitis during cephalothin therapy . Ann Intern Med 78:347-351, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Cephaloridine in Meningitis

Archives of Otolaryngology , Volume 102 (10) – Oct 1, 1976

Cephaloridine in Meningitis

Abstract

Abstract To the Editor.—I read with interest the report of Newlands1 concerning meningitis after stapedectomy. It is essential that the otologic surgeon be prepared to handle this complication at an early stage to preserve the life of his patient. The use of cephaloridine may not be effective in treating or preventing meningitis, however. An article in a recent issue of the Medical Letter2 based on a consensus of its infectious disease consultants recommends chloramphenicol as the...
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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1976.00780150113019
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.—I read with interest the report of Newlands1 concerning meningitis after stapedectomy. It is essential that the otologic surgeon be prepared to handle this complication at an early stage to preserve the life of his patient. The use of cephaloridine may not be effective in treating or preventing meningitis, however. An article in a recent issue of the Medical Letter2 based on a consensus of its infectious disease consultants recommends chloramphenicol as the first-choice antibiotic in penicillinallergic individuals with pneumococcal meningitis and states that cephalosporins are not generally recommended for the treatment of this disease. Likewise, a recent review by Moellering and Swartz' emphasizes the poor penetration of cephalosporins into cerebrospinal fluid, representing one of the greatest drawbacks of this class of antibiotics. Fisher et al4 found that only 76% of 72 patients with meningitis responded favorably to cephaloridine, despite intrathecal administration in many cases. References 1. Newlands WJ: Poststapedectomy otitis media and meningitis . Arch Otolaryngol 102:51-56, 1976.Crossref 2. The Medical Letter 18:9-16, (Jan 30) , 1976. 3. Moellering RE Jr, Swartz MN: Drug therapy: The newer cephalosporins . N Engl J Med 294:24-28, 1976.Crossref 4. Fisher LS, Chow AW, Yoshikawa TT, et al: Cephalothin and cephaloridine therapy for bacterial meningitis: An evaluation . Ann Intern Med 82:689-693, 1975.Crossref 5. Mangi RJ, Kundargi RS, Quintiliani R, et al: Development of meningitis during cephalothin therapy . Ann Intern Med 78:347-351, 1973.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Oct 1, 1976

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