Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Lymphocyte Response in Patients With Head and Neck Cancer: Effect of Clinical Stage and Radiotherapy

Lymphocyte Response in Patients With Head and Neck Cancer: Effect of Clinical Stage and Radiotherapy Abstract • Fifty-three patients with head and neck cancer tested before radiation treatment to determine numbers of blood lymphocytes and immunologic responses to mitogens of lymphocytes in whole-blood cultures had mean values that were 19% to 26% less than values for healthy individuals. Thirty patients whose disease was in stages III or IV had values similar to those in 23 patients whose disease was in stages I or II. Values for 45 patients tested at end of radiotherapy decreased to about 50% of pretreatment values; however, patients with advanced lesions experienced greater decreases (to 24% to 50%) than patients with localized lesions (to 71% to 84%). Patients with advanced lesions usually received radiation to larger areas than patients with localized lesions; therefore, the extent of decline in laboratory values was most likely dependent on volume of tissue treated. (Arch Otolaryngol 102:596-600, 1976) References 1. Catalona WJ, Sample WF, Chretien PB: Lymphocyte reactivity in cancer patients: Correlation with tumor histology and clinical stage . Cancer 31:65-71, 1973.Crossref 2. Harris J, Copeland D: Impaired immunoresponsiveness in tumor patients . Ann NY Acad Sci 230:56-85, 1974.Crossref 3. Hellstrom I, Hellstrom KE, Sjorgren HO, et al: Demonstration of cell-mediated immunity to human neoplasms of various histological types . Int J Cancer 7:1-16, 1971.Crossref 4. Eilber FR, Morton DL: Impaired immunologic reactivity and recurrence following cancer surgery . Cancer 25:362-367, 1970.Crossref 5. O'Toole C, Perlmann P, Unsgaard B, et al: Cellular immunity to human urinary bladder carcinoma: I. Correlation to clinical stage and radiotherapy . Int J Cancer 10:77-91, 1972.Crossref 6. Fisher B, Slack NH, Cavanaugh PJ, et al: Postoperative radiotherapy in treatment of breast cancer: Results of the NSABP clinical trial . Ann Surg 172:711-732, 1970.Crossref 7. Deodhar SD, Crile Jr G, Esselstyn Jr CB: Study of the tumor cell-lymphocyte interaction in patients with breast cancer . Cancer 29:1321-1325, 1972.Crossref 8. Dao TL, Kovaric J: Incidence of pulmonary and skin metastases in women with breast cancer who received post-operative irradiation . Surgery 52:203-212, 1962. 9. Meyer KK: Radiation-induced lymphocyte-immune deficiency: A factor in the increased visceral metastases and decreased hormonal responsiveness of breast cancer . Arch Surg 101:114-121, 1970.Crossref 10. Stjernsward J, Jondal M, Vanky F, et al: Lymphopenia and change in distribution of human B and T lymphocytes in peripheral blood induced by irradiation for mammary carcinoma . Lancet 1:1352-1356, 1972.Crossref 11. Gatti RA, Garrioch DB, Good RA: Depressed PHA responses in patients with nonlymphoid malignancies , in Harris JE (ed): Proceedings of the Fifth Leukocyte Culture Conference . New York, Adademic Press, 1970, pp 339-358. 12. Mekori T, Sher S, Robinson E: Suppression of the mitogenic response to phytohemagglutinin in malignant neoplasia: Correlation with clinical stage of therapy . J Natl Cancer Inst 52:9-12, 1974. 13. Whittaker MG, Rees K, Clark CG: Reduced lymphocyte transformation in breast cancer . Lancet 1:892-893, 1971.Crossref 14. Jenkins VK, Olson MH, Ellis HN, et al: In vitro lymphocyte response of patients with uterine cancer as related to clinical stage and radiotherapy . Gynecol Oncol 3:191-200, 1975.Crossref 15. Clinical Staging System for Carcinoma of the Larynx , American Joint Committee for Cancer Staging and End Results Reporting. Chicago, American College of Surgeons, 1972. 16. Clinical Staging System for Carcinoma of the Oral Cavity , American Joint Committee for Cancer Staging and End Results Reporting. Chicago, American College of Surgeons, 1968. 17. Clinical Classification and Staging of the Pharynx , American Joint Committee for Cancer Staging and End Results Reporting. Chicago, American College of Surgeons, 1965. 18. Pauly JL, Sokal JE, Han T: Whole-blood culture technique for functional studies of lymphocyte reactivity to mitogens, antigens, and homologous lymphocytes . J Lab Clin Med 82:500-513, 1973. 19. Pauly JL, Sokal JE: A simplified technique for in vitro studies of lymphocyte reactivity . Proc Soc Exp Biol Med 140:40-44, 1972.Crossref 20. Jenkins VK, Olson MH, Ellis HN: In vitro methods of assessing lymphocyte transformation in patients undergoing radiotherapy for bronchogenic cancer . Tex Rep Biol Med 31:19-28, 1973. 21. Jenkins VK, Olson MH, Cooley RN, et al: Effect of therapeutic radiation on peripheral blood lymphocytes in patients with carcinoma of the breast . Acta Radiol 14:385-395, 1975.Crossref 22. Andersson J, Moller G, Sjoberg O: B lymphocytes can be stimulated by Concanavalin A in the presence of humoral factors released by T cells . Eur J Immunol 2:99-101, 1972.Crossref 23. Janossy G, Greaves MF: Lymphocyte activation: I. Response of T and B lymphocytes to phytomitogens . Clin Exp Immunol 9:483-498, 1971. 24. Byrd W, Boehmer H, Rouse BT: The role of the thymus in maturational developments of phytohemagglutinin and pokeweed mitogen responsiveness . Cell Immunol 6:12-24, 1973.Crossref 25. Weksler ME, Bodine S, Rommer J: Response of lymphocytes to plant lectins: I. A thymic-dependent lymphoid population responsive to pokeweed mitogen . Immunology 16:281-290, 1974. 26. Curtis JE, Hersh EM, Harris JE, et al: The human primary immune response to keyhole limpet haemocyanin: Inter-relationships of delayed hypersensitivity, antibody response and in vitro blast transformation . Clin Exp Immunol 6:473-491, 1970. 27. Cosimi AB, Brunstetter FH, Kemmerer WT, et al: Cellular immune competence of breast cancer patients receiving radiotherapy . Arch Surg 107:531-535, 1973.Crossref 28. Gross L, Manfredi OL, Protos AA: Effect of Cobalt-60 irradiation upon cell-mediated immunity . Radiology 106:653-655, 1973.Crossref 29. Clement JA, Kramer S: Immunocompetence in patients with solid tumors undergoing Cobalt 60 irradiation . Cancer 34:193-196, 1974.Crossref 30. McCredie JA, Inch WR, Sutherland RM: Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast . Cancer 29:349-356, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Lymphocyte Response in Patients With Head and Neck Cancer: Effect of Clinical Stage and Radiotherapy

Loading next page...
 
/lp/american-medical-association/lymphocyte-response-in-patients-with-head-and-neck-cancer-effect-of-Jx03l0ckX6

References (31)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1976.00780150064003
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fifty-three patients with head and neck cancer tested before radiation treatment to determine numbers of blood lymphocytes and immunologic responses to mitogens of lymphocytes in whole-blood cultures had mean values that were 19% to 26% less than values for healthy individuals. Thirty patients whose disease was in stages III or IV had values similar to those in 23 patients whose disease was in stages I or II. Values for 45 patients tested at end of radiotherapy decreased to about 50% of pretreatment values; however, patients with advanced lesions experienced greater decreases (to 24% to 50%) than patients with localized lesions (to 71% to 84%). Patients with advanced lesions usually received radiation to larger areas than patients with localized lesions; therefore, the extent of decline in laboratory values was most likely dependent on volume of tissue treated. (Arch Otolaryngol 102:596-600, 1976) References 1. Catalona WJ, Sample WF, Chretien PB: Lymphocyte reactivity in cancer patients: Correlation with tumor histology and clinical stage . Cancer 31:65-71, 1973.Crossref 2. Harris J, Copeland D: Impaired immunoresponsiveness in tumor patients . Ann NY Acad Sci 230:56-85, 1974.Crossref 3. Hellstrom I, Hellstrom KE, Sjorgren HO, et al: Demonstration of cell-mediated immunity to human neoplasms of various histological types . Int J Cancer 7:1-16, 1971.Crossref 4. Eilber FR, Morton DL: Impaired immunologic reactivity and recurrence following cancer surgery . Cancer 25:362-367, 1970.Crossref 5. O'Toole C, Perlmann P, Unsgaard B, et al: Cellular immunity to human urinary bladder carcinoma: I. Correlation to clinical stage and radiotherapy . Int J Cancer 10:77-91, 1972.Crossref 6. Fisher B, Slack NH, Cavanaugh PJ, et al: Postoperative radiotherapy in treatment of breast cancer: Results of the NSABP clinical trial . Ann Surg 172:711-732, 1970.Crossref 7. Deodhar SD, Crile Jr G, Esselstyn Jr CB: Study of the tumor cell-lymphocyte interaction in patients with breast cancer . Cancer 29:1321-1325, 1972.Crossref 8. Dao TL, Kovaric J: Incidence of pulmonary and skin metastases in women with breast cancer who received post-operative irradiation . Surgery 52:203-212, 1962. 9. Meyer KK: Radiation-induced lymphocyte-immune deficiency: A factor in the increased visceral metastases and decreased hormonal responsiveness of breast cancer . Arch Surg 101:114-121, 1970.Crossref 10. Stjernsward J, Jondal M, Vanky F, et al: Lymphopenia and change in distribution of human B and T lymphocytes in peripheral blood induced by irradiation for mammary carcinoma . Lancet 1:1352-1356, 1972.Crossref 11. Gatti RA, Garrioch DB, Good RA: Depressed PHA responses in patients with nonlymphoid malignancies , in Harris JE (ed): Proceedings of the Fifth Leukocyte Culture Conference . New York, Adademic Press, 1970, pp 339-358. 12. Mekori T, Sher S, Robinson E: Suppression of the mitogenic response to phytohemagglutinin in malignant neoplasia: Correlation with clinical stage of therapy . J Natl Cancer Inst 52:9-12, 1974. 13. Whittaker MG, Rees K, Clark CG: Reduced lymphocyte transformation in breast cancer . Lancet 1:892-893, 1971.Crossref 14. Jenkins VK, Olson MH, Ellis HN, et al: In vitro lymphocyte response of patients with uterine cancer as related to clinical stage and radiotherapy . Gynecol Oncol 3:191-200, 1975.Crossref 15. Clinical Staging System for Carcinoma of the Larynx , American Joint Committee for Cancer Staging and End Results Reporting. Chicago, American College of Surgeons, 1972. 16. Clinical Staging System for Carcinoma of the Oral Cavity , American Joint Committee for Cancer Staging and End Results Reporting. Chicago, American College of Surgeons, 1968. 17. Clinical Classification and Staging of the Pharynx , American Joint Committee for Cancer Staging and End Results Reporting. Chicago, American College of Surgeons, 1965. 18. Pauly JL, Sokal JE, Han T: Whole-blood culture technique for functional studies of lymphocyte reactivity to mitogens, antigens, and homologous lymphocytes . J Lab Clin Med 82:500-513, 1973. 19. Pauly JL, Sokal JE: A simplified technique for in vitro studies of lymphocyte reactivity . Proc Soc Exp Biol Med 140:40-44, 1972.Crossref 20. Jenkins VK, Olson MH, Ellis HN: In vitro methods of assessing lymphocyte transformation in patients undergoing radiotherapy for bronchogenic cancer . Tex Rep Biol Med 31:19-28, 1973. 21. Jenkins VK, Olson MH, Cooley RN, et al: Effect of therapeutic radiation on peripheral blood lymphocytes in patients with carcinoma of the breast . Acta Radiol 14:385-395, 1975.Crossref 22. Andersson J, Moller G, Sjoberg O: B lymphocytes can be stimulated by Concanavalin A in the presence of humoral factors released by T cells . Eur J Immunol 2:99-101, 1972.Crossref 23. Janossy G, Greaves MF: Lymphocyte activation: I. Response of T and B lymphocytes to phytomitogens . Clin Exp Immunol 9:483-498, 1971. 24. Byrd W, Boehmer H, Rouse BT: The role of the thymus in maturational developments of phytohemagglutinin and pokeweed mitogen responsiveness . Cell Immunol 6:12-24, 1973.Crossref 25. Weksler ME, Bodine S, Rommer J: Response of lymphocytes to plant lectins: I. A thymic-dependent lymphoid population responsive to pokeweed mitogen . Immunology 16:281-290, 1974. 26. Curtis JE, Hersh EM, Harris JE, et al: The human primary immune response to keyhole limpet haemocyanin: Inter-relationships of delayed hypersensitivity, antibody response and in vitro blast transformation . Clin Exp Immunol 6:473-491, 1970. 27. Cosimi AB, Brunstetter FH, Kemmerer WT, et al: Cellular immune competence of breast cancer patients receiving radiotherapy . Arch Surg 107:531-535, 1973.Crossref 28. Gross L, Manfredi OL, Protos AA: Effect of Cobalt-60 irradiation upon cell-mediated immunity . Radiology 106:653-655, 1973.Crossref 29. Clement JA, Kramer S: Immunocompetence in patients with solid tumors undergoing Cobalt 60 irradiation . Cancer 34:193-196, 1974.Crossref 30. McCredie JA, Inch WR, Sutherland RM: Effect of postoperative radiotherapy on peripheral blood lymphocytes in patients with carcinoma of the breast . Cancer 29:349-356, 1972.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Oct 1, 1976

There are no references for this article.