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Abnormal Microorganisms and Cell-Mediated Immunity in Patients With Intraoral Cancer

Abnormal Microorganisms and Cell-Mediated Immunity in Patients With Intraoral Cancer Abstract • A substantial number of patients with intraoral malignant neoplasms have abnormal bacterial flora of skin, nasopharynx, and oropharynx, without a demonstrable relationship between tumor size, location, or degree of ulceration.1 Seventeen consecutive patients were studied to determine what relationship, if any, exists between the presence of abnormal microorganisms and the patients' immunological competence. Ten of 17 patients grew potentially pathogenic organisms, and all reacted to specific skin tests used to infer immunological competence. Thus, there appeared to be no relationship between cellular immunity and the presence of abnormal bacteria in patients with intraoral malignant neoplasms. (Arch Otolaryngol 102:99-100, 1976) References 1. Gill G, Rice DH: The effect of external irradiation on the bacterial flora of patients with intraoral malignancies. Read before the American College of Surgeons Meeting, San Francisco, October, 1975. 2. Mandel MA, Kiehn CL: The prognostic significance of delayed cutaneous reactivity in head and neck cancer patients . Plast Reconstr Surg 53:72-76, 1974.Crossref 3. Maisel RH, Ogura JH: Abnormal dinitrochlorobenzene skin sensitization: A prognostic sign of survival in head and neck squamous cell carcinoma . Laryngoscope 83:2012-2018, 1973.Crossref 4. Eilber FR, Morton DL: Impaired immunologic reactivity and recurrence following cancer surgery . Cancer 25:362-367, 1970.Crossref 5. Glasgow AH, Nimberg RB, Menzoian JO, et al: Association of anergy with an immunosuppressive peptide fraction in the serum of patients with cancer . N Engl J Med 291:1263-1267, 1974.Crossref 6. Kelly WD, Good RA, Varco RL: Anergy and skin homograft survival in Hodgkin's disease . Surg Gynecol Obstet 107:565-570, 1958. 7. Waldorf DS, Willkins RF, Decker JL: Impaired delayed hypersensitivity in an aging population . JAMA 203:831-834, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Abnormal Microorganisms and Cell-Mediated Immunity in Patients With Intraoral Cancer

Archives of Otolaryngology , Volume 102 (2) – Feb 1, 1976

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1976.00780070077010
Publisher site
See Article on Publisher Site

Abstract

Abstract • A substantial number of patients with intraoral malignant neoplasms have abnormal bacterial flora of skin, nasopharynx, and oropharynx, without a demonstrable relationship between tumor size, location, or degree of ulceration.1 Seventeen consecutive patients were studied to determine what relationship, if any, exists between the presence of abnormal microorganisms and the patients' immunological competence. Ten of 17 patients grew potentially pathogenic organisms, and all reacted to specific skin tests used to infer immunological competence. Thus, there appeared to be no relationship between cellular immunity and the presence of abnormal bacteria in patients with intraoral malignant neoplasms. (Arch Otolaryngol 102:99-100, 1976) References 1. Gill G, Rice DH: The effect of external irradiation on the bacterial flora of patients with intraoral malignancies. Read before the American College of Surgeons Meeting, San Francisco, October, 1975. 2. Mandel MA, Kiehn CL: The prognostic significance of delayed cutaneous reactivity in head and neck cancer patients . Plast Reconstr Surg 53:72-76, 1974.Crossref 3. Maisel RH, Ogura JH: Abnormal dinitrochlorobenzene skin sensitization: A prognostic sign of survival in head and neck squamous cell carcinoma . Laryngoscope 83:2012-2018, 1973.Crossref 4. Eilber FR, Morton DL: Impaired immunologic reactivity and recurrence following cancer surgery . Cancer 25:362-367, 1970.Crossref 5. Glasgow AH, Nimberg RB, Menzoian JO, et al: Association of anergy with an immunosuppressive peptide fraction in the serum of patients with cancer . N Engl J Med 291:1263-1267, 1974.Crossref 6. Kelly WD, Good RA, Varco RL: Anergy and skin homograft survival in Hodgkin's disease . Surg Gynecol Obstet 107:565-570, 1958. 7. Waldorf DS, Willkins RF, Decker JL: Impaired delayed hypersensitivity in an aging population . JAMA 203:831-834, 1968.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Feb 1, 1976

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