Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Epstein-Barr Virus Associated With Episodes of Recurrent Tonsillitis

Epstein-Barr Virus Associated With Episodes of Recurrent Tonsillitis Abstract • A group of patients with a history of recurrent tonsillitis were observed during an acute episode to determine the cause of the infection. The microbial pathogen that was consistently implicated was the Epstein-Barr virus. Seventeen (65%) of 26 patients exhibited a substantial seroconversion to the early antigen of Epstein-Barr-virus-infected lymphoblastoid cells (P3HR-1). We conclude that there is a high incidence of tonsillitis associated with the Epstein-Barr virus. The propensity of the virus for the palatine tonsils, a rich source of B cells, is suggested. Furthermore, the value of monitoring early antigen titers to confirm the nature of the infection is apparent, bearing relevance to future studies of this virus. (Arch Otolaryngol 101:552-556, 1975) References 1. Burkitt DP: A lymphoma syndrome in tropical Africa . Int Rev Exp Pathol 2:69-136, 1963. 2. Epstein MA, Achong BG, Barr YM, et al: Virus particles in cultured lymphoblasts from Burkitt's lymphoma . Lancet 1:702-703, 1964.Crossref 3. Henle G, Henle W: Immunofluorescence in cells derived from Burkitt's lymphoma . J Bacteriol 91:1248-1256, 1966. 4. Henle G, Henle W, Diehl V: Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis . Proc Natl Acad Sci USA 59:94-101, 1968.Crossref 5. DeSchryver A, Friberg S Jr, Klein G, et al: Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space . Clin Exp Immunol 5:443-459, 1969. 6. Henle W, Henle G, Burtin P, et al: Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and control groups . J Natl Cancer Inst 44:225-231, 1970. 7. Johansson B, Klein G, Henle G, et al: Epstein-Barr virus (EBV) associated antibody patterns in malignant lymphoma and leukemia: I. Hodgkin's disease . Int J Cancer 6:450, 1970.Crossref 8. Henle W, Henle G: Evidence for an oncogenic potential of the Epstein-Barr virus . Cancer Res 33:1419-1423, 1973. 9. Klein G: Herpes viruses and oncogenesis . Proc Natl Acad Sci USA 69:1056-1064, 1972.Crossref 10. Rapp R: Question: Do herpes viruses cause cancer? Answer: Of course they do . J Natl Cancer Inst 50:825-832, 1973. 11. Henle G, Henle W: Observations on childhood infections with the Epstein-Barr virus . J Infect Dis 121:303-310, 1970.Crossref 12. Schmitz H, Volz D, Krainick-Reichert C, et al: Acute Epstein-Barr infections in children . Med Microbiol Immunol 158:58-63, 1972.Crossref 13. Tischendorf P, Shramek GJ, Balagtas RC, et al: Development and persistence of immunity to Epstein-Barr virus in man . J Infect Dis 122:401-409, 1970.Crossref 14. Evans AS, Neiderman JC, McCollum EN: Seroepidemiologic studies of infectious mononucleosis with EB virus . N Engl J Med 279:1121-1127, 1968.Crossref 15. Beltran G, Northington JW, Leiderman E, et al: Antibody to human cell lines with and without ultrastructural evidence for Epstein-Barr virus (EBV) infection in sera from patients with diverse viral illnesses . Int J Cancer 7:375-379, 1971.Crossref 16. Porter D, Wimberly I, Benyesh-Melnick M: Prevalence of antibodies to EB virus and other herpes viruses . JAMA 208:1965-1967, 1969.Crossref 17. Demissie A, Svedmyr A: Age distribution of antibodies to EB virus in Swedish females as studied by indirect immunofluorescence on Burkitt cells . Acta Pathol Microbiol Scand 75:457-465, 1969. 18. Hinuma Y, Ohta-Hatano R, Suto T, et al: High incidence of Japanese infants with antibody to a herpes-type virus associated with cultured Burkitt lymphoma cells . Jap J Microbiol 13:309-311, 1969.Crossref 19. Neiderman JD, Evans AS, Subrahmanyan L, et al: Prevalence, incidence and persistence of EB virus antibody in young adults . N Engl J Med 282:361-365, 1970.Crossref 20. Veltri RW, Sprinkle PM, Keller SA, et al: Ecological alterations of oral microflora subsequent to tonsillectomy and adenoidectomy . J Laryngol Otol 86:893-903, 1972.Crossref 21. Blair JE, Lennette EH, Truant JP (eds): Manual of Clinical Microbiology , ed 1, Bethesda, Md, American Society for Microbiology, 1970, pp 61-386. 22. Hsuing GD: Diagnostic Virology . New Haven, Conn, Yale University Press, 1973. 23. Veltri RW, Sprinkle PM, Keller SA, et al: Immunoglobulin changes in a patient sample subsequent to tonsillectomy and adenoidectomy . J Laryngol Oto 86:905-916, 1972. 24. Paul JR, Bunnell WW: The presence of heterophile antibodies in infectious mononucleosis . Am J Med Sci 183:90-94, 1932.Crossref 25. Oberhofer TR, Hajkowski R: Evaluation of the microtiter technic for heterophilic antibody determinations . Am J Clin Pathol 53:498-505, 1970. 26. Glaser R, O'Neill FJ: Hybridization of Burkitt lymphoblastoid cells . Science 176:1245-1247, 1972.Crossref 27. Henle W, Henle G, Zajac BA, et al: Differential reactivity of human serums with early antigens induced by Epstein-Barr virus . Science 169:188-190, 1970.Crossref 28. Hinuma Y, Kinn M, Yamaguchi J, et al: Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line . J Virol 1:1045-1051, 1967. 29. Gerber P, Lucas S: Epstein-Barr virus associated antigens activated in human cells by 5-bromodeoxy uridine . Proc Soc Exp Biol Med 141:431-435, 1972.Crossref 30. Didier-Fichet ML, De-Thé G: Induction d'une expression virale par le 5-bromodeoxyuridine (iuDR) dans les ligne'es issues de lymphomes de Burkitt et de cancers du rhinopharynx . C R Acad Sci 274:2549-2552, 1972. 31. Hampar B, Derge JG, Martas DM, et al: Identification of a critical period during the S phase for activation of the Epstein-Barr virus by 5-iododeoxyruidine . Nature New Biol 244:214-217, 1973.Crossref 32. Sloyer JL, Veltri RW, Sprinkle PM: In vitro IgM antibody synthesis by human tonsil derived lymphocytes . J Immunol 111:183-188, 1973. 33. Schmitz H, Scherer M: IgM antibodies to Epstein-Barr virus in infectious mononucleosis . Arch Ges Virusforsch 37:332-339, 1972.Crossref 34. Bantavala JE, Best JM, Waller DK: Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma and nasopharyngeal carcinoma . Lancet 1:1205-1208, 1972.Crossref 35. Mantanoski GM, Price WH, Ferencz C: epidemiology of streptococcal infections in rheumatic and non-rheumatic families: III. Comparison of the immune response to streptococcal infections in the two populations . Am J Epidemiol 87:207-225, 1968. 36. Miller G, Neiderman JC, Andrews L: Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis . N Engl J Med 288:229-232, 1973.Crossref 37. Gerber P, Lucas S, Nonoyama M, et al: Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis . Lancet 2:988-989, 1972.Crossref 38. Dayton DH, Small PA, Chanock RM, et al: The Secretory Immunologic System. Bethesda , Md, Public Health Service, National Institutes of Health, 1971, pp 1-544. 39. Henle G, Henle W, Klein G, et al: Antibodies to early EBV-induced antigens in Burkitt's lymphoma . J Natl Cancer Inst 46:861-871, 1971. 40. Henle W, Henle G, Gunven P, et al: Patterns of antibodies to Epstein-Barr virus induced early antigens in Burkitt's lymphoma . J Natl Cancer Inst 50:1163-1173, 1973. 41. Plotkin S, Farquhar JD, Ogra PL: Immunologic properties of RA 27/3 Rubella vaccine . JAMA 225:585-590, 1973.Crossref 42. Diehl V, Wolf H, Holthausen-Schultze H, et al: Re-exposure of human lymphoblastoid cell lines to Epstein-Barr virus . Int J Cancer 10:641-651, 1972.Crossref 43. Cedrig L, Derge JG, Hampar B: Procedure for activating Epstein-Barr virus early antigen in non-producer cells by 5-iododeoxyuridine . J Natl Cancer Inst 52:1355-1357, 1974. 44. Klein G: Immunological studies on Burkitt's lymphoma . Postgrad Med J 47:141-155, 1971.Crossref 45. Werner J, Pinto CA, Haff RF, et al: Response of Gibbons to inoculation of Epstein-Barr virus . J Infect Dis 126:678-681, 1972.Crossref 46. Reedman BM, Klein G: Cellular localization of an Epstein-Barr virus (EBV) associated complement-fixing antigen in producer and nonproducer lymphoblastoid cell lines . J Natl Cancer Inst 11:499-520, 1973.Crossref 47. Nonoyama M, Pagano JS: Detection of Epstein-Barr viral genome in non-productive cells . Nature New Biol 233:103-106, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Epstein-Barr Virus Associated With Episodes of Recurrent Tonsillitis

Download PDF
5 pages

Loading next page...
 
/lp/american-medical-association/epstein-barr-virus-associated-with-episodes-of-recurrent-tonsillitis-cl0q6UQ3ek

References (52)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1975.00780380030007
Publisher site
See Article on Publisher Site

Abstract

Abstract • A group of patients with a history of recurrent tonsillitis were observed during an acute episode to determine the cause of the infection. The microbial pathogen that was consistently implicated was the Epstein-Barr virus. Seventeen (65%) of 26 patients exhibited a substantial seroconversion to the early antigen of Epstein-Barr-virus-infected lymphoblastoid cells (P3HR-1). We conclude that there is a high incidence of tonsillitis associated with the Epstein-Barr virus. The propensity of the virus for the palatine tonsils, a rich source of B cells, is suggested. Furthermore, the value of monitoring early antigen titers to confirm the nature of the infection is apparent, bearing relevance to future studies of this virus. (Arch Otolaryngol 101:552-556, 1975) References 1. Burkitt DP: A lymphoma syndrome in tropical Africa . Int Rev Exp Pathol 2:69-136, 1963. 2. Epstein MA, Achong BG, Barr YM, et al: Virus particles in cultured lymphoblasts from Burkitt's lymphoma . Lancet 1:702-703, 1964.Crossref 3. Henle G, Henle W: Immunofluorescence in cells derived from Burkitt's lymphoma . J Bacteriol 91:1248-1256, 1966. 4. Henle G, Henle W, Diehl V: Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis . Proc Natl Acad Sci USA 59:94-101, 1968.Crossref 5. DeSchryver A, Friberg S Jr, Klein G, et al: Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space . Clin Exp Immunol 5:443-459, 1969. 6. Henle W, Henle G, Burtin P, et al: Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and control groups . J Natl Cancer Inst 44:225-231, 1970. 7. Johansson B, Klein G, Henle G, et al: Epstein-Barr virus (EBV) associated antibody patterns in malignant lymphoma and leukemia: I. Hodgkin's disease . Int J Cancer 6:450, 1970.Crossref 8. Henle W, Henle G: Evidence for an oncogenic potential of the Epstein-Barr virus . Cancer Res 33:1419-1423, 1973. 9. Klein G: Herpes viruses and oncogenesis . Proc Natl Acad Sci USA 69:1056-1064, 1972.Crossref 10. Rapp R: Question: Do herpes viruses cause cancer? Answer: Of course they do . J Natl Cancer Inst 50:825-832, 1973. 11. Henle G, Henle W: Observations on childhood infections with the Epstein-Barr virus . J Infect Dis 121:303-310, 1970.Crossref 12. Schmitz H, Volz D, Krainick-Reichert C, et al: Acute Epstein-Barr infections in children . Med Microbiol Immunol 158:58-63, 1972.Crossref 13. Tischendorf P, Shramek GJ, Balagtas RC, et al: Development and persistence of immunity to Epstein-Barr virus in man . J Infect Dis 122:401-409, 1970.Crossref 14. Evans AS, Neiderman JC, McCollum EN: Seroepidemiologic studies of infectious mononucleosis with EB virus . N Engl J Med 279:1121-1127, 1968.Crossref 15. Beltran G, Northington JW, Leiderman E, et al: Antibody to human cell lines with and without ultrastructural evidence for Epstein-Barr virus (EBV) infection in sera from patients with diverse viral illnesses . Int J Cancer 7:375-379, 1971.Crossref 16. Porter D, Wimberly I, Benyesh-Melnick M: Prevalence of antibodies to EB virus and other herpes viruses . JAMA 208:1965-1967, 1969.Crossref 17. Demissie A, Svedmyr A: Age distribution of antibodies to EB virus in Swedish females as studied by indirect immunofluorescence on Burkitt cells . Acta Pathol Microbiol Scand 75:457-465, 1969. 18. Hinuma Y, Ohta-Hatano R, Suto T, et al: High incidence of Japanese infants with antibody to a herpes-type virus associated with cultured Burkitt lymphoma cells . Jap J Microbiol 13:309-311, 1969.Crossref 19. Neiderman JD, Evans AS, Subrahmanyan L, et al: Prevalence, incidence and persistence of EB virus antibody in young adults . N Engl J Med 282:361-365, 1970.Crossref 20. Veltri RW, Sprinkle PM, Keller SA, et al: Ecological alterations of oral microflora subsequent to tonsillectomy and adenoidectomy . J Laryngol Otol 86:893-903, 1972.Crossref 21. Blair JE, Lennette EH, Truant JP (eds): Manual of Clinical Microbiology , ed 1, Bethesda, Md, American Society for Microbiology, 1970, pp 61-386. 22. Hsuing GD: Diagnostic Virology . New Haven, Conn, Yale University Press, 1973. 23. Veltri RW, Sprinkle PM, Keller SA, et al: Immunoglobulin changes in a patient sample subsequent to tonsillectomy and adenoidectomy . J Laryngol Oto 86:905-916, 1972. 24. Paul JR, Bunnell WW: The presence of heterophile antibodies in infectious mononucleosis . Am J Med Sci 183:90-94, 1932.Crossref 25. Oberhofer TR, Hajkowski R: Evaluation of the microtiter technic for heterophilic antibody determinations . Am J Clin Pathol 53:498-505, 1970. 26. Glaser R, O'Neill FJ: Hybridization of Burkitt lymphoblastoid cells . Science 176:1245-1247, 1972.Crossref 27. Henle W, Henle G, Zajac BA, et al: Differential reactivity of human serums with early antigens induced by Epstein-Barr virus . Science 169:188-190, 1970.Crossref 28. Hinuma Y, Kinn M, Yamaguchi J, et al: Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line . J Virol 1:1045-1051, 1967. 29. Gerber P, Lucas S: Epstein-Barr virus associated antigens activated in human cells by 5-bromodeoxy uridine . Proc Soc Exp Biol Med 141:431-435, 1972.Crossref 30. Didier-Fichet ML, De-Thé G: Induction d'une expression virale par le 5-bromodeoxyuridine (iuDR) dans les ligne'es issues de lymphomes de Burkitt et de cancers du rhinopharynx . C R Acad Sci 274:2549-2552, 1972. 31. Hampar B, Derge JG, Martas DM, et al: Identification of a critical period during the S phase for activation of the Epstein-Barr virus by 5-iododeoxyruidine . Nature New Biol 244:214-217, 1973.Crossref 32. Sloyer JL, Veltri RW, Sprinkle PM: In vitro IgM antibody synthesis by human tonsil derived lymphocytes . J Immunol 111:183-188, 1973. 33. Schmitz H, Scherer M: IgM antibodies to Epstein-Barr virus in infectious mononucleosis . Arch Ges Virusforsch 37:332-339, 1972.Crossref 34. Bantavala JE, Best JM, Waller DK: Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma and nasopharyngeal carcinoma . Lancet 1:1205-1208, 1972.Crossref 35. Mantanoski GM, Price WH, Ferencz C: epidemiology of streptococcal infections in rheumatic and non-rheumatic families: III. Comparison of the immune response to streptococcal infections in the two populations . Am J Epidemiol 87:207-225, 1968. 36. Miller G, Neiderman JC, Andrews L: Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis . N Engl J Med 288:229-232, 1973.Crossref 37. Gerber P, Lucas S, Nonoyama M, et al: Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis . Lancet 2:988-989, 1972.Crossref 38. Dayton DH, Small PA, Chanock RM, et al: The Secretory Immunologic System. Bethesda , Md, Public Health Service, National Institutes of Health, 1971, pp 1-544. 39. Henle G, Henle W, Klein G, et al: Antibodies to early EBV-induced antigens in Burkitt's lymphoma . J Natl Cancer Inst 46:861-871, 1971. 40. Henle W, Henle G, Gunven P, et al: Patterns of antibodies to Epstein-Barr virus induced early antigens in Burkitt's lymphoma . J Natl Cancer Inst 50:1163-1173, 1973. 41. Plotkin S, Farquhar JD, Ogra PL: Immunologic properties of RA 27/3 Rubella vaccine . JAMA 225:585-590, 1973.Crossref 42. Diehl V, Wolf H, Holthausen-Schultze H, et al: Re-exposure of human lymphoblastoid cell lines to Epstein-Barr virus . Int J Cancer 10:641-651, 1972.Crossref 43. Cedrig L, Derge JG, Hampar B: Procedure for activating Epstein-Barr virus early antigen in non-producer cells by 5-iododeoxyuridine . J Natl Cancer Inst 52:1355-1357, 1974. 44. Klein G: Immunological studies on Burkitt's lymphoma . Postgrad Med J 47:141-155, 1971.Crossref 45. Werner J, Pinto CA, Haff RF, et al: Response of Gibbons to inoculation of Epstein-Barr virus . J Infect Dis 126:678-681, 1972.Crossref 46. Reedman BM, Klein G: Cellular localization of an Epstein-Barr virus (EBV) associated complement-fixing antigen in producer and nonproducer lymphoblastoid cell lines . J Natl Cancer Inst 11:499-520, 1973.Crossref 47. Nonoyama M, Pagano JS: Detection of Epstein-Barr viral genome in non-productive cells . Nature New Biol 233:103-106, 1971.Crossref

Journal

Archives of Otolaryngology – American Medical Association

Published: Sep 1, 1975

There are no references for this article.