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Benign Lymphoepithelial Lesions of the Salivary Glands

Benign Lymphoepithelial Lesions of the Salivary Glands Abstract The benign lymphoepithelial lesion of the salivary glands has been labeled with multiple, confusing terms. We recommend the abandonment of the vague term of Mikulicz disease. The histopathologic findings of lymphoid infiltration, intraductal proliferation, epimyoepithelial islands, and acinar atrophy are presented. The relationship between this lesion and autoimmune diseases, including Sjögren syndrome, is noted. Difficulty of histopathologic differentiation between this lesion and malignant lymphoma can occur. The association of the benign lymphoepithelial lesion with the simultaneous presence or future development of lymphoma is discussed. References 1. Mikulicz J: Concerning a peculiar symmetrical disease of the salivary glands . Med Classics 2:165-186, 1973. 2. Sjögren H: Zur kenntnis der keratoconjunctivitis sicca (keratitis filiformis bei hypofunction der tränendrüsen.) Acta Ophthalmol 2( (suppl) ):1-151, 1933. 3. Lloyd OC: Salivary adenoma and adenolymphoma . J Pathol Bacteriol 58:699-710, 1946.Crossref 4. Baver WH, Baver JD: Classification of glandular tumors of salivary glands: Study of 143 cases . Arch Pathol 55:328-346, 1953. 5. Swinton NW, Warren S: Salivary gland tumors . Surg Gynec Obstet 67:424-435, 1938. 6. Maxwell JH: Chronic lymphoepithelial sialadenopathy with sialodochiectasis . Trans Amer Acad Ophthalmol Otolaryngol 64:225-234, 1960. 7. Hemenway WG: Chronic Punctate Parotitis . Boulder, Colo, Associated University Press, 1971. 8. Fein MJ: Lympho-epithelioma of the parotid gland . Am J Cancer 40:434-440, 1940. 9. Godwin JT: Benign lymphoepithelial lesion of the parotid gland (adenolymphoma, chronic inflammation, lymphoepithelioma, lymphocytic tumor, Mikulicz disease): Report of 11 cases . Cancer 5:1089-1103, 1952.Crossref 10. Morgan WS, Castleman B: A clinicopathologic study of "Mikulicz's disease." Am J Pathol 29:471-489, 1953. 11. Blatt IM: On sialectasis and benign lymphosialadenopathy (the pyogenic parotitis, Gougerot-Sjögren's syndrome, Mikulicz's disease complex): A ten-year study . Laryngoscope 74:1684, 1964.Crossref 12. Patey DH, Thackray AC: Chronic "sialectatic" parotitis in the light of pathological studies on parotidectomy material . Br J Surg 43:43, 1955.Crossref 13. DuPlessis DI: Some important features in the development, structure, and function of the parotid salivary glands . S Afr Med J 31:773,1957. 14. Batsakis JG, Weaver DK, McBurney T: Controversial lympho reticular lesions of the head and neck: Mickulicz's disease and syndrome, Sjögren's syndrome, benign lymphoepithelial lesion of salivary glands, and "malignant granuloma." Univ Mich Med Center J 36:8-13, 1970. 15. Morgan WS: The probable systemic nature of Mikulicz's disease and its relation to Sjögren's syndrome . N Engl J Med 251:5-9, 1954.Crossref 16. Meyer D, Yanoff M, Hanno H: Differential diagnosis in Mikulicz's syndrome, Mikulicz's disease, and similar disease entities . Am J Ophthalmol 71:516-524, 1971. 17. Evans RW, Cruickshank AH: Mikulicz-Sjögren syndrome, solid adenolymphoma, benign lymphoepithelial lesion and lymphomatoid adenoma , in Epithelial Tumors of the Salivary Glands . Philadelphia, WB Saunders Co, pp 279-295, 1970. 18. Sidahara G: Ein operativ geheilter fall von lymphosarkom de parotis . Gann 31:41, 1937. 19. Azzopardi JG, Evans DJ: malignant lymphoma of parotid associated with Mikulicz's disease (benign lymphoepithelial lesion) . J Clin Pathol 24:744-752, 1971.Crossref 20. Schnitzer B: M alignant lymphomas . Univ Mich Med Center J 36:23-28, 1970. 21. Talal N, Bunim JJ: The development of malignant lymphoma in the course of Sjögren's syndrome . Am J Med 36:529, 1964.Crossref 22. Pinkus GS, Dekker A: Benign lymphoepithelial lesion of the parotid glands associated with reticulum cell sarcoma . Cancer 25:121-127, 1970.Crossref 23. Work WP, Hect DW: Non-neoplastic lesions of the parotid gland . Ann Otol Rhinol Laryngol 77:462, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Benign Lymphoepithelial Lesions of the Salivary Glands

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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1975.00780300075020
Publisher site
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Abstract

Abstract The benign lymphoepithelial lesion of the salivary glands has been labeled with multiple, confusing terms. We recommend the abandonment of the vague term of Mikulicz disease. The histopathologic findings of lymphoid infiltration, intraductal proliferation, epimyoepithelial islands, and acinar atrophy are presented. The relationship between this lesion and autoimmune diseases, including Sjögren syndrome, is noted. Difficulty of histopathologic differentiation between this lesion and malignant lymphoma can occur. The association of the benign lymphoepithelial lesion with the simultaneous presence or future development of lymphoma is discussed. References 1. Mikulicz J: Concerning a peculiar symmetrical disease of the salivary glands . Med Classics 2:165-186, 1973. 2. Sjögren H: Zur kenntnis der keratoconjunctivitis sicca (keratitis filiformis bei hypofunction der tränendrüsen.) Acta Ophthalmol 2( (suppl) ):1-151, 1933. 3. Lloyd OC: Salivary adenoma and adenolymphoma . J Pathol Bacteriol 58:699-710, 1946.Crossref 4. Baver WH, Baver JD: Classification of glandular tumors of salivary glands: Study of 143 cases . Arch Pathol 55:328-346, 1953. 5. Swinton NW, Warren S: Salivary gland tumors . Surg Gynec Obstet 67:424-435, 1938. 6. Maxwell JH: Chronic lymphoepithelial sialadenopathy with sialodochiectasis . Trans Amer Acad Ophthalmol Otolaryngol 64:225-234, 1960. 7. Hemenway WG: Chronic Punctate Parotitis . Boulder, Colo, Associated University Press, 1971. 8. Fein MJ: Lympho-epithelioma of the parotid gland . Am J Cancer 40:434-440, 1940. 9. Godwin JT: Benign lymphoepithelial lesion of the parotid gland (adenolymphoma, chronic inflammation, lymphoepithelioma, lymphocytic tumor, Mikulicz disease): Report of 11 cases . Cancer 5:1089-1103, 1952.Crossref 10. Morgan WS, Castleman B: A clinicopathologic study of "Mikulicz's disease." Am J Pathol 29:471-489, 1953. 11. Blatt IM: On sialectasis and benign lymphosialadenopathy (the pyogenic parotitis, Gougerot-Sjögren's syndrome, Mikulicz's disease complex): A ten-year study . Laryngoscope 74:1684, 1964.Crossref 12. Patey DH, Thackray AC: Chronic "sialectatic" parotitis in the light of pathological studies on parotidectomy material . Br J Surg 43:43, 1955.Crossref 13. DuPlessis DI: Some important features in the development, structure, and function of the parotid salivary glands . S Afr Med J 31:773,1957. 14. Batsakis JG, Weaver DK, McBurney T: Controversial lympho reticular lesions of the head and neck: Mickulicz's disease and syndrome, Sjögren's syndrome, benign lymphoepithelial lesion of salivary glands, and "malignant granuloma." Univ Mich Med Center J 36:8-13, 1970. 15. Morgan WS: The probable systemic nature of Mikulicz's disease and its relation to Sjögren's syndrome . N Engl J Med 251:5-9, 1954.Crossref 16. Meyer D, Yanoff M, Hanno H: Differential diagnosis in Mikulicz's syndrome, Mikulicz's disease, and similar disease entities . Am J Ophthalmol 71:516-524, 1971. 17. Evans RW, Cruickshank AH: Mikulicz-Sjögren syndrome, solid adenolymphoma, benign lymphoepithelial lesion and lymphomatoid adenoma , in Epithelial Tumors of the Salivary Glands . Philadelphia, WB Saunders Co, pp 279-295, 1970. 18. Sidahara G: Ein operativ geheilter fall von lymphosarkom de parotis . Gann 31:41, 1937. 19. Azzopardi JG, Evans DJ: malignant lymphoma of parotid associated with Mikulicz's disease (benign lymphoepithelial lesion) . J Clin Pathol 24:744-752, 1971.Crossref 20. Schnitzer B: M alignant lymphomas . Univ Mich Med Center J 36:23-28, 1970. 21. Talal N, Bunim JJ: The development of malignant lymphoma in the course of Sjögren's syndrome . Am J Med 36:529, 1964.Crossref 22. Pinkus GS, Dekker A: Benign lymphoepithelial lesion of the parotid glands associated with reticulum cell sarcoma . Cancer 25:121-127, 1970.Crossref 23. Work WP, Hect DW: Non-neoplastic lesions of the parotid gland . Ann Otol Rhinol Laryngol 77:462, 1968.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Jan 1, 1975

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