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Intravenous and Optimum-Dosage Histamine Therapy in Meniere's Disease

Intravenous and Optimum-Dosage Histamine Therapy in Meniere's Disease Abstract Reexamination of accepted techniques of histamine therapy for episodic vertigos in the light of clinical experience and recent laboratory studies suggests than an optimum dosage of exogenous histamine may be of therapeutic value in selected cases. Patients surmised to be capable of manifesting an abnormal response to stress by local microcirculatory dysfunction are, theoretically, favorable candidates for such therapy. Microvascular dysfunction of the cochlear or vestibular labyrinth may or may not contraindicate intravenous histamine therapy. References 1. Schayer RW: The normal cell and its response to allergic stimuli , in: Report of the Thirty-Eighth Ross Conference on Pediatric Research . Columbus, Ohio, Ross Laboratories, 1961, pp 52-57. 2. Schayer RW: Evidence that induced histamine is an intrinsic regulator of the microcirculation system . Am J Physiol 202:66-72, 1962. 3. Majno G, Gilmore V, Leventhal M: On the mechanism of vascular leakage caused by histamine-type mediators . Circ Res 21:833-847, 1967.Crossref 4. Zeller EA: Enzymes . New York, Academic Press Inc, 1963, vol 8, p 313. 5. Brown DD, Tomchick R, Axelrod J: The distribution and properties of a histaminemethylating enzyme . J Biol Chem 234( (pt 4) ):2948-2950, 1959. 6. Reilly MA, Schayer RW: In vivo studies on histamine catabolism and its inhibition . Br J Pharmacol 38:478-489, 1970.Crossref 7. Krajewska JM, Maslinski C: Plasma diamine oxidase activity after single or chronic administration of histamine . Eur J Pharmacol 7:300-306, 1969.Crossref 8. Hansel FK: Treatment of certain specific types of headache with histamine . Ann Otol Rhinol Laryngol 56:152-160, 1947. 9. Rinkel HJ: Inhalant allergy: III. The co-seasonal application of serial dilution testing (titration) . Ann Allergy 7:645-693, 1949. 10. Albers GD, Wilson WH: Diplacusis . Arch Otolaryngol 87:601-614, 1968.Crossref 11. Shambaugh GE Jr: Surgery of the Ear . Philadelphia, WB Saunders Co, 1967, pp 621-622. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Intravenous and Optimum-Dosage Histamine Therapy in Meniere's Disease

Wilson, William H.
Archives of Otolaryngology , Volume 97 (2) – Feb 1, 1973
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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1973.00780010145009
Publisher site
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Abstract

Abstract Reexamination of accepted techniques of histamine therapy for episodic vertigos in the light of clinical experience and recent laboratory studies suggests than an optimum dosage of exogenous histamine may be of therapeutic value in selected cases. Patients surmised to be capable of manifesting an abnormal response to stress by local microcirculatory dysfunction are, theoretically, favorable candidates for such therapy. Microvascular dysfunction of the cochlear or vestibular labyrinth may or may not contraindicate intravenous histamine therapy. References 1. Schayer RW: The normal cell and its response to allergic stimuli , in: Report of the Thirty-Eighth Ross Conference on Pediatric Research . Columbus, Ohio, Ross Laboratories, 1961, pp 52-57. 2. Schayer RW: Evidence that induced histamine is an intrinsic regulator of the microcirculation system . Am J Physiol 202:66-72, 1962. 3. Majno G, Gilmore V, Leventhal M: On the mechanism of vascular leakage caused by histamine-type mediators . Circ Res 21:833-847, 1967.Crossref 4. Zeller EA: Enzymes . New York, Academic Press Inc, 1963, vol 8, p 313. 5. Brown DD, Tomchick R, Axelrod J: The distribution and properties of a histaminemethylating enzyme . J Biol Chem 234( (pt 4) ):2948-2950, 1959. 6. Reilly MA, Schayer RW: In vivo studies on histamine catabolism and its inhibition . Br J Pharmacol 38:478-489, 1970.Crossref 7. Krajewska JM, Maslinski C: Plasma diamine oxidase activity after single or chronic administration of histamine . Eur J Pharmacol 7:300-306, 1969.Crossref 8. Hansel FK: Treatment of certain specific types of headache with histamine . Ann Otol Rhinol Laryngol 56:152-160, 1947. 9. Rinkel HJ: Inhalant allergy: III. The co-seasonal application of serial dilution testing (titration) . Ann Allergy 7:645-693, 1949. 10. Albers GD, Wilson WH: Diplacusis . Arch Otolaryngol 87:601-614, 1968.Crossref 11. Shambaugh GE Jr: Surgery of the Ear . Philadelphia, WB Saunders Co, 1967, pp 621-622.

Journal

Archives of Otolaryngology – American Medical Association

Published: Feb 1, 1973

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