Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Diphenidol and Vestibular Function: A Comparative Study With Chlorpromazine in Rabbits

Diphenidol and Vestibular Function: A Comparative Study With Chlorpromazine in Rabbits Abstract INCREASING interest has been displayed in the development of potent and specific antivertigo drugs which are relatively free of the side effects noted with many of the agents in use today. Diphenidol (Vontrol) was introduced as an antivertigo, antiemetic agent which does not exhibit the side effects that may accompany antihistamines or phenothiazines.1 These effects include sedation, hypotension, and extrapyramidal signs. Chemically, diphenidol (Vontrol) is α, α-diphenyl-1-piperidinebutanol. Studies have suggested that this drug has its effect upon the central vestibular mechanism and the chemoreceptor trigger zone.1 Clinical evaluations of diphenidol indicate that it is an effective antiemetic, and can be useful in controlling labyrinthine vertigo.2 Cutt et al3 used diphenidol and dimenhydrinate (Dramamine) as vestibular depressants in squirrel monkeys which were subsequently subjected to caloric stimulation. The duration of nystagmus was measured visually, and although both agents appeared to be active vestibular depressants, no significant difference References 1. Leonard, C.A., et al: Observations on the Pharmacology of Diphenidol: A Potent Antiemetic , J Pharmacol Exp Ther 154:339-345 ( (Nov) ) 1966. 2. Yost, R.M.: Clinical Studies with Diphenidol: A New Compound With Antiemetic and Antivertigo Activity , Clin Med 74:50-52 ( (July) ) 1967. 3. Cutt, R.A., et al: A Caloric Test in the Monkey and its Application for Drug Evaluation , Ann Otol 76:436-446 ( (June) ) 1967. 4. Smith, Kline & French Laboratories: Vontrol, Brand of Diphenidol: Clinical Reports of 2,298 Patients (March) 1967. 5. New SKF Antiemetic Vontrol Curbed by Adverse Reactions , Med Trib 8:11 ( (July 20) ) 1967. 6. Diphenidol (Vontrol) , Med Lett Drugs Ther 9 ( (Nov) ) 1967. 7. Goodman, L.S., and Gilman, A.: The Pharmacologic Basis of Therapeutics ed 3, New York: Macmillan Co., Publishers 1965, pp 162-179. 8. Bergström, O., and Koch, H.: The Effect of Chlorpromazine on the Vestibular Function , Acta Otolaryng 46:484-498 ( (Nov) -Dec) 1956.Crossref 9. Eviatar, A., and Goodhill, V.: Comparative Sequential Studies of Effects of Drugs on the Vestibular System of Laboratory Animals, Acta Otolaryng Suppl, to be published. 10. Norris, C., and Rubin, W.: Nystagmography and Vertigo, presented as a scientific exhibit at the American Academy of Ophthalmology and Otolaryngology, Chicago, Nov 14-19, 1965. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Diphenidol and Vestibular Function: A Comparative Study With Chlorpromazine in Rabbits

Download PDF
6 pages

Loading next page...
 
/lp/american-medical-association/diphenidol-and-vestibular-function-a-comparative-study-with-2I9FbC3TOY

References (7)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1969.00770020490009
Publisher site
See Article on Publisher Site

Abstract

Abstract INCREASING interest has been displayed in the development of potent and specific antivertigo drugs which are relatively free of the side effects noted with many of the agents in use today. Diphenidol (Vontrol) was introduced as an antivertigo, antiemetic agent which does not exhibit the side effects that may accompany antihistamines or phenothiazines.1 These effects include sedation, hypotension, and extrapyramidal signs. Chemically, diphenidol (Vontrol) is α, α-diphenyl-1-piperidinebutanol. Studies have suggested that this drug has its effect upon the central vestibular mechanism and the chemoreceptor trigger zone.1 Clinical evaluations of diphenidol indicate that it is an effective antiemetic, and can be useful in controlling labyrinthine vertigo.2 Cutt et al3 used diphenidol and dimenhydrinate (Dramamine) as vestibular depressants in squirrel monkeys which were subsequently subjected to caloric stimulation. The duration of nystagmus was measured visually, and although both agents appeared to be active vestibular depressants, no significant difference References 1. Leonard, C.A., et al: Observations on the Pharmacology of Diphenidol: A Potent Antiemetic , J Pharmacol Exp Ther 154:339-345 ( (Nov) ) 1966. 2. Yost, R.M.: Clinical Studies with Diphenidol: A New Compound With Antiemetic and Antivertigo Activity , Clin Med 74:50-52 ( (July) ) 1967. 3. Cutt, R.A., et al: A Caloric Test in the Monkey and its Application for Drug Evaluation , Ann Otol 76:436-446 ( (June) ) 1967. 4. Smith, Kline & French Laboratories: Vontrol, Brand of Diphenidol: Clinical Reports of 2,298 Patients (March) 1967. 5. New SKF Antiemetic Vontrol Curbed by Adverse Reactions , Med Trib 8:11 ( (July 20) ) 1967. 6. Diphenidol (Vontrol) , Med Lett Drugs Ther 9 ( (Nov) ) 1967. 7. Goodman, L.S., and Gilman, A.: The Pharmacologic Basis of Therapeutics ed 3, New York: Macmillan Co., Publishers 1965, pp 162-179. 8. Bergström, O., and Koch, H.: The Effect of Chlorpromazine on the Vestibular Function , Acta Otolaryng 46:484-498 ( (Nov) -Dec) 1956.Crossref 9. Eviatar, A., and Goodhill, V.: Comparative Sequential Studies of Effects of Drugs on the Vestibular System of Laboratory Animals, Acta Otolaryng Suppl, to be published. 10. Norris, C., and Rubin, W.: Nystagmography and Vertigo, presented as a scientific exhibit at the American Academy of Ophthalmology and Otolaryngology, Chicago, Nov 14-19, 1965.

Journal

Archives of Otolaryngology – American Medical Association

Published: Mar 1, 1969

There are no references for this article.