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Droperidol and Fentanyl Citrate Compound as a Vestibular Depressant

Droperidol and Fentanyl Citrate Compound as a Vestibular Depressant Abstract MUCH attention has been directed in recent years to the growing field of active, potent drugs suggested for use in combating the symptoms of vertigo. Often such drugs have been employed previously for unrelated purposes, but their effects on the vestibular system have been observed only secondarily. Droperidol and fentanyl citrate (Innovar), a drug originally introduced as an adjunct to general anesthesia,1 later was used to induce neuroleptanalgesia,2,3 the main characteristics of which are indifference, hypomotility, and analgesia. Neuroleptanalgesia is a state under which minor surgical procedures can be performed and thus has been advocated for endoscopic procedures.4 Dowdy et al5 observed that droperidol and fentanyl citrate depresses vestibular activity, and proposed its use in the treatment of Meniere's disease. Fentanyl citrate is a narcotic, related structurally to meperidin and pharmacologically to both meperidin and morphine. Its chemistry has been described by Janssen.6 It is References 1. Holderness, M.C.; Chase, P.E.; and Dribbis, R.D.: Use of a Narcotic Analgesic and a Butyrophenone With Nitrous Oxide for General Anesthesia , Anesthesiology 24:336-340 ( (May) -June) 1963.Crossref 2. Nilsson, E.: Origin and Rationale of Neurolept-Analgesia , Anesthesiology 24:267 ( (May) -June) 1963.Crossref 3. Nilsson, E., and Janssen, P.A.J.: Neuroleptanalgesia: An Alternative to General Anesthesia , Acta Anaesth Scandinav 5:73 ( (July) ) 1961.Crossref 4. Farb, S., and Tornetta, F.J.: Topical Endoscopic Anesthesia With Two New Adjuncts , Eye Ear Nose Throat Monthly 44:56-58 ( (Oct) ) 1965. 5. Dowdy, E.G., et al: A New Treatment of Meniere's Disease , Arch Otolaryng 82:491-497 ( (Nov) ) 1965.Crossref 6. Janssen, P.A.: A Review of the Chemical Features Associated With Strong Morphine-Like Activity , Brit J Anesth 34:260-267 ( (April) ) 1962.Crossref 7. Gardocki, J.F., and Yelonsky, J.: A Study of Some of the Pharmacological Actions of Fentanyl Citrate , Toxic Appl Pharmacol 6:48-62 ( (Jan) ) 1964.Crossref 8. Janssen, P.A., et al: The Pharmacology of Dehydrobenzperidol (R-4749): A New Potent and Short Acting Neuroleptic Agent Chemically Related to Haloperidol , Arzneimittelforschung 13:205-211 ( (March) ) 1963. 9. Yelonsky, J.; Katz, R.; and Dieterich, E.V.: A Study of Some of the Pharmacological Actions of Droperidol , Toxic Appl Pharmacol 6:37-47 ( (Jan) ) 1964.Crossref 10. Yelonsky, J.; Katz, R.; and Dieterich, E.V.: A Study of Some of the Pharmacological Actions of Fentanyl Citrate and Droperidol , Toxic Appl Pharmacol 6:63 ( (Jan) ) 1964.Crossref 11. Gorodetsky, C.W., and Martin, W.R.: A Comparison of Fentanyl, Droperidol, and Morphine , Clin Pharmacol Ther 6:731-739 ( (Nov) -Dec) 1965. 12. Gardocki, J.F., et al: A Study of the Interaction of Nalorphine With Fentanyl and Innovar , Toxic Appl Pharmacol 6:593-601 ( (Sept) ) 1964.Crossref 13. Eviatar, A., and Goodhill, V.: Comparative Sequential Studies of Effects of Drugs on the Vestibular System of Laboratory Animals, Acta Otolaryng, suppl, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Droperidol and Fentanyl Citrate Compound as a Vestibular Depressant

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1969.00770020484008
Publisher site
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Abstract

Abstract MUCH attention has been directed in recent years to the growing field of active, potent drugs suggested for use in combating the symptoms of vertigo. Often such drugs have been employed previously for unrelated purposes, but their effects on the vestibular system have been observed only secondarily. Droperidol and fentanyl citrate (Innovar), a drug originally introduced as an adjunct to general anesthesia,1 later was used to induce neuroleptanalgesia,2,3 the main characteristics of which are indifference, hypomotility, and analgesia. Neuroleptanalgesia is a state under which minor surgical procedures can be performed and thus has been advocated for endoscopic procedures.4 Dowdy et al5 observed that droperidol and fentanyl citrate depresses vestibular activity, and proposed its use in the treatment of Meniere's disease. Fentanyl citrate is a narcotic, related structurally to meperidin and pharmacologically to both meperidin and morphine. Its chemistry has been described by Janssen.6 It is References 1. Holderness, M.C.; Chase, P.E.; and Dribbis, R.D.: Use of a Narcotic Analgesic and a Butyrophenone With Nitrous Oxide for General Anesthesia , Anesthesiology 24:336-340 ( (May) -June) 1963.Crossref 2. Nilsson, E.: Origin and Rationale of Neurolept-Analgesia , Anesthesiology 24:267 ( (May) -June) 1963.Crossref 3. Nilsson, E., and Janssen, P.A.J.: Neuroleptanalgesia: An Alternative to General Anesthesia , Acta Anaesth Scandinav 5:73 ( (July) ) 1961.Crossref 4. Farb, S., and Tornetta, F.J.: Topical Endoscopic Anesthesia With Two New Adjuncts , Eye Ear Nose Throat Monthly 44:56-58 ( (Oct) ) 1965. 5. Dowdy, E.G., et al: A New Treatment of Meniere's Disease , Arch Otolaryng 82:491-497 ( (Nov) ) 1965.Crossref 6. Janssen, P.A.: A Review of the Chemical Features Associated With Strong Morphine-Like Activity , Brit J Anesth 34:260-267 ( (April) ) 1962.Crossref 7. Gardocki, J.F., and Yelonsky, J.: A Study of Some of the Pharmacological Actions of Fentanyl Citrate , Toxic Appl Pharmacol 6:48-62 ( (Jan) ) 1964.Crossref 8. Janssen, P.A., et al: The Pharmacology of Dehydrobenzperidol (R-4749): A New Potent and Short Acting Neuroleptic Agent Chemically Related to Haloperidol , Arzneimittelforschung 13:205-211 ( (March) ) 1963. 9. Yelonsky, J.; Katz, R.; and Dieterich, E.V.: A Study of Some of the Pharmacological Actions of Droperidol , Toxic Appl Pharmacol 6:37-47 ( (Jan) ) 1964.Crossref 10. Yelonsky, J.; Katz, R.; and Dieterich, E.V.: A Study of Some of the Pharmacological Actions of Fentanyl Citrate and Droperidol , Toxic Appl Pharmacol 6:63 ( (Jan) ) 1964.Crossref 11. Gorodetsky, C.W., and Martin, W.R.: A Comparison of Fentanyl, Droperidol, and Morphine , Clin Pharmacol Ther 6:731-739 ( (Nov) -Dec) 1965. 12. Gardocki, J.F., et al: A Study of the Interaction of Nalorphine With Fentanyl and Innovar , Toxic Appl Pharmacol 6:593-601 ( (Sept) ) 1964.Crossref 13. Eviatar, A., and Goodhill, V.: Comparative Sequential Studies of Effects of Drugs on the Vestibular System of Laboratory Animals, Acta Otolaryng, suppl, to be published.

Journal

Archives of Otolaryngology – American Medical Association

Published: Mar 1, 1969

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