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The Melkersson-Rosenthal Syndrome

The Melkersson-Rosenthal Syndrome Abstract IN 1928, Melkersson1 wrote of a 35-year-old female patient afflicted with facial paralysis and facial edema. In 1931, Rosenthal2 described two families who displayed three cases of lingua plicata associated with the facial paralyses and facial edema. Prior to these descriptions, Hubschmann,3 in 1894, and Rossolimo,4 in 1901, reported syndromes of relapsing facial paralyses and facial edema, but the triad of seventh nerve palsy, facial edema, and lingua plicata was not attributed to Melkersson until Ekbom so declared it in his honor. Hubschmann did not note the tongue involvement, and Rossolimo augmented the triad to include migraine headaches. The European literature contains abundant reports referable to the Melkersson-Rosenthal syndrome. In the British and American literature, such reports are sparse. The purpose of this article is to arouse the reader to the existence of this entity, its prognostic implications, and its management. In 1933, New and Kirch References 1. Melkersson, E.: Et fall ay recidiverande facilspares i samband med angioneurotiskt öden , Hygiea 90:737, 1928. 2. Rosenthal, C.: Klinisch-ebbiologischer Beitrag zur Konstitutionspathologic. Gemeinsames Auftreten von (rezidivierender familiärer) Facialislähmung, angioneurotischem Gesichtsödem und Lingua plicata in Arthritismus-Familien , Z Neurol Psychiat 131:475-501, 1931.Crossref 3. Hubschmann, Von P.: Ueber Recidive und Diplegie bei der sogenannten rheumatischen Facialislähmung , Zbl Neurochir 13:815, 1894. 4. Rossolimo, G.J.: Recidiverende Facialislähmung bei Migräne , Zbl Neurochir 20:744, 1901. 5. New, G.B., and Kirch, W.A.: Permanent Enlargement of Lips and Face Secondary to Recurring Swellings and Associated With Facial Paralysis: Clinical Entity , JAMA 100:1230-1233 ( (April 22) ) 1933.Crossref 6. Kettel, K.: Melkersson's Syndrome , Arch Otolaryng 46:341-360 ( (Sept) ) 1947.Crossref 7. Kettel, K.: Surgical Treatment in Atraumatic Facial Palsies , J Laryng 73:491 ( (Aug) ) 1959.Crossref 8. Conway, H.: Macrocheilia Due to Hyperplasia of the Labial Salivary Glands: Operative Correction , Surg Gynec Obstet 66:1024 ( (June) ) 1938. 9. McGovern, F.H.: Melkersson's Syndrome , Arch Otolaryng 51:371-377 ( (March) ) 1950.Crossref 10. Hilger, J.A.: The Nature of Bell's Palsy , Laryngoscope 59:228 ( (March) ) 1949. 11. Ascher, K.W.: Blepharochalasis mit Struma und Doppellippe , Klin Mbl Augenheilk 65:86, 1920. 12. Ekbom, K.A.: Plicated Tongue in Melkersson's Syndrome and in Paralysis of the Facial Nerve , Acta Med Scand 138:42, 1950.Crossref 13. Cockayne, E.A.: Inherited Abnormalities of the Skin and Its Appendages , New York: Oxford University Press, Inc, 1933, pp 95, 209. 14. Aukland, G.: Melkersson's Syndrome , Brit J Derm 70:458 ( (May) ) 1958.Crossref 15. Miescher, G.: Über Essentielle Granulomatöse, Makrocheilie , Dermatologica 91:57, 1945.Crossref 16. Laymon, C.W.: Cheilitis Granulomatosa and Melkersson-Rosenthal Syndrome , Arch Derm 83:112 ( (Jan) ) 1961.Crossref 17. Findlay, G.H.: Idiopathic Enlargements of the Lips: Cheilitis Granulomatosa, Ascher's Syndrome and Double Lip , Brit J Derm 66:129, 1954.Crossref 18. Stevens, F.A.: Streptococci Infection of the "Fibroedema" of Melkersson's Syndrome , JAMA 156:223-224 ( (Sept 18) ) 1954.Crossref 19. Klaus, S.N., and Brunsting, L.A.: Melkersson's Syndrome (Persistent Swelling of the Face, Recurrent Facial Paralysis, and Lingua Plicata): Report of Case , Proc Mayo Clin 34:365 ( (July 22) ) 1959. 20. Barley, D., and Jolly, H.: Melkersson's Syndrome , Proc Roy Soc Med 53:787 ( (Sept) ) 1960. 21. Abu-Jaudeh, C.N.: Melkersson's Syndrome , Ann Otol 69:989 ( (Dec) ) 1960. 22. Cairns, R.J.: Melkersson-Rosenthal Syndrome , Proc Roy Soc Med 54:217 ( (March) ) 1961. 23. Wallk, S., and Bluefarb, S.M.: Melkersson-Rosenthal Syndrome , Arch Derm 84:798 ( (Nov) ) 1961.Crossref 24. Aderhold, K.; Krönke, E.; and Pawlik, H.J.: Melkersson-Rosenthal Syndrom mit Megacolon Congenitum , Deutsch Gesundh 12:513, 1957. 25. Panebianco, G., and Manara, E.: La sindrome di Melkersson-Rosenthal, observazione di die casi , Otorinolaring Ital 25:493, 1957. 26. Scott, G.A.: Melkersson's Syndrome , Brit J Clin Pract 18:415 ( (July) ) 1964. 27. Stumpf, W., and Schuppener, H.J.: Das Melkersson-Rosenthal Syndrom: Untersuchungen zur Psychogenese , Klin Wschr 35:882 ( (Sept) ) 1957.Crossref 28. Streeto, J.M., and Watters, F.B.: Melkersson's Syndrome: Multiple Recurrences of Bell's Palsy and Episodic Facial Edema , New Eng J Med 271:308 ( (Aug 6) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

The Melkersson-Rosenthal Syndrome

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References (33)

Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1966.00760030294006
Publisher site
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Abstract

Abstract IN 1928, Melkersson1 wrote of a 35-year-old female patient afflicted with facial paralysis and facial edema. In 1931, Rosenthal2 described two families who displayed three cases of lingua plicata associated with the facial paralyses and facial edema. Prior to these descriptions, Hubschmann,3 in 1894, and Rossolimo,4 in 1901, reported syndromes of relapsing facial paralyses and facial edema, but the triad of seventh nerve palsy, facial edema, and lingua plicata was not attributed to Melkersson until Ekbom so declared it in his honor. Hubschmann did not note the tongue involvement, and Rossolimo augmented the triad to include migraine headaches. The European literature contains abundant reports referable to the Melkersson-Rosenthal syndrome. In the British and American literature, such reports are sparse. The purpose of this article is to arouse the reader to the existence of this entity, its prognostic implications, and its management. In 1933, New and Kirch References 1. Melkersson, E.: Et fall ay recidiverande facilspares i samband med angioneurotiskt öden , Hygiea 90:737, 1928. 2. Rosenthal, C.: Klinisch-ebbiologischer Beitrag zur Konstitutionspathologic. Gemeinsames Auftreten von (rezidivierender familiärer) Facialislähmung, angioneurotischem Gesichtsödem und Lingua plicata in Arthritismus-Familien , Z Neurol Psychiat 131:475-501, 1931.Crossref 3. Hubschmann, Von P.: Ueber Recidive und Diplegie bei der sogenannten rheumatischen Facialislähmung , Zbl Neurochir 13:815, 1894. 4. Rossolimo, G.J.: Recidiverende Facialislähmung bei Migräne , Zbl Neurochir 20:744, 1901. 5. New, G.B., and Kirch, W.A.: Permanent Enlargement of Lips and Face Secondary to Recurring Swellings and Associated With Facial Paralysis: Clinical Entity , JAMA 100:1230-1233 ( (April 22) ) 1933.Crossref 6. Kettel, K.: Melkersson's Syndrome , Arch Otolaryng 46:341-360 ( (Sept) ) 1947.Crossref 7. Kettel, K.: Surgical Treatment in Atraumatic Facial Palsies , J Laryng 73:491 ( (Aug) ) 1959.Crossref 8. Conway, H.: Macrocheilia Due to Hyperplasia of the Labial Salivary Glands: Operative Correction , Surg Gynec Obstet 66:1024 ( (June) ) 1938. 9. McGovern, F.H.: Melkersson's Syndrome , Arch Otolaryng 51:371-377 ( (March) ) 1950.Crossref 10. Hilger, J.A.: The Nature of Bell's Palsy , Laryngoscope 59:228 ( (March) ) 1949. 11. Ascher, K.W.: Blepharochalasis mit Struma und Doppellippe , Klin Mbl Augenheilk 65:86, 1920. 12. Ekbom, K.A.: Plicated Tongue in Melkersson's Syndrome and in Paralysis of the Facial Nerve , Acta Med Scand 138:42, 1950.Crossref 13. Cockayne, E.A.: Inherited Abnormalities of the Skin and Its Appendages , New York: Oxford University Press, Inc, 1933, pp 95, 209. 14. Aukland, G.: Melkersson's Syndrome , Brit J Derm 70:458 ( (May) ) 1958.Crossref 15. Miescher, G.: Über Essentielle Granulomatöse, Makrocheilie , Dermatologica 91:57, 1945.Crossref 16. Laymon, C.W.: Cheilitis Granulomatosa and Melkersson-Rosenthal Syndrome , Arch Derm 83:112 ( (Jan) ) 1961.Crossref 17. Findlay, G.H.: Idiopathic Enlargements of the Lips: Cheilitis Granulomatosa, Ascher's Syndrome and Double Lip , Brit J Derm 66:129, 1954.Crossref 18. Stevens, F.A.: Streptococci Infection of the "Fibroedema" of Melkersson's Syndrome , JAMA 156:223-224 ( (Sept 18) ) 1954.Crossref 19. Klaus, S.N., and Brunsting, L.A.: Melkersson's Syndrome (Persistent Swelling of the Face, Recurrent Facial Paralysis, and Lingua Plicata): Report of Case , Proc Mayo Clin 34:365 ( (July 22) ) 1959. 20. Barley, D., and Jolly, H.: Melkersson's Syndrome , Proc Roy Soc Med 53:787 ( (Sept) ) 1960. 21. Abu-Jaudeh, C.N.: Melkersson's Syndrome , Ann Otol 69:989 ( (Dec) ) 1960. 22. Cairns, R.J.: Melkersson-Rosenthal Syndrome , Proc Roy Soc Med 54:217 ( (March) ) 1961. 23. Wallk, S., and Bluefarb, S.M.: Melkersson-Rosenthal Syndrome , Arch Derm 84:798 ( (Nov) ) 1961.Crossref 24. Aderhold, K.; Krönke, E.; and Pawlik, H.J.: Melkersson-Rosenthal Syndrom mit Megacolon Congenitum , Deutsch Gesundh 12:513, 1957. 25. Panebianco, G., and Manara, E.: La sindrome di Melkersson-Rosenthal, observazione di die casi , Otorinolaring Ital 25:493, 1957. 26. Scott, G.A.: Melkersson's Syndrome , Brit J Clin Pract 18:415 ( (July) ) 1964. 27. Stumpf, W., and Schuppener, H.J.: Das Melkersson-Rosenthal Syndrom: Untersuchungen zur Psychogenese , Klin Wschr 35:882 ( (Sept) ) 1957.Crossref 28. Streeto, J.M., and Watters, F.B.: Melkersson's Syndrome: Multiple Recurrences of Bell's Palsy and Episodic Facial Edema , New Eng J Med 271:308 ( (Aug 6) ) 1964.Crossref

Journal

Archives of Otolaryngology – American Medical Association

Published: Sep 1, 1966

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