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Kapferer Jm (1962)
[Experience with "neuroleptanalgesia"].Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression
J. Decastro (1959)
Anesthesia sans barbiturique: la neuroleptanalgesiaAnesth Analg (Paris), 16
M. Holderness, P. Chase, R. Dripps (1963)
A Narcotic Analgesic and a Butyrophenone with Nitrous Oxide for General AnesthesiaAnesthesiology, 24
E. Nilsson (1962)
[Experiences with neuroleptic analgesia].Der Anaesthesist, 11
A. Dobkin, J. Israel, P. Byles (1964)
Innovan-N2O anaesthesia in normal men effect on respiration, circulatory dynamics, liver function, metabolic functions, acid-base balance, and psychic responsesCanadian Anaesthetists’ Society Journal, 11
G. Corssen , E.F. Domino, R.B. and Sweet (1964)
Neurolept-Analgesia and Anesthesia: Pharmacologic and Clinical ConsiderationsAnesth Analg (Cleveland), 43
Abstract Vestibular Depression by a Droperidol-Fentanyl Combination JANSSEN has recently developed several analgesic and hypnotic drugs.1 Two of these have been used in combination to produce an anesthetic state.2-6 They are droperidol and fentanyl citrate (Innovar), with a droperidolfentanyl ratio of 50:1. One cubic centimeter of the mixture contains 0.05 mg fentanyl and 2.5 mg droperidol.Fentanyl is a highly potent analgesic with a rapid onset and short duration of action. It possesses a weak emetic action and produces mild vagal stimulation. Droperidol belongs to an entirely new class of compounds known as butyrophenones. It produces sedation and a state of psychic detachment but leaves the patient able to cooperate intelligently on demand. Its onset is from five to ten minutes and lasts more than six hours. Droperidol possesses potent antiemetic properties and seems to protect against some ventricular arrhythmias. In combination these drugs produce an anesthetic condition that References 1. Janssen Research Products Information Service, Teratological Data of Innovar, Research Laboratorium Dr. C. Janssen. 2. Decastro, J., and Mundeleer, P.: Anesthesia sans barbiturique: la neuroleptanalgesia , Anesth Analg (Paris) 16:1022-1056, 1959. 3. Holderness, M.C.; Chase, P.E.; and Dripps, R.D.: A Narcotic Analgesic and a Butyrophenone With Nitrous Oxide for General Anesthesia , Anesthesiology 24:336-340, 1963.Crossref 4. Corssen, G.; Domino, E.F.; and Sweet, R.B.: Neurolept-Analgesia and Anesthesia: Pharmacologic and Clinical Considerations , Anesth Analg (Cleveland) 43:744, 1964. 5. Dobkin, A.B.; Israel, J.S.; and Byles, P.H.: Innovar-N2O Anaesthesia in Normal Men: Effect on Respiration, Circulatory Dynamics, Liver Function, Metabolic Functions, Acid-Base Balance, and Psychic Responses , Can Anaesth Soc J 11:41, 1964.Crossref 6. Nilsson, E.: Experience With Neuroleptanalgesia , Anaesthesist 11:17, 1962.
Archives of Otolaryngology – American Medical Association
Published: Nov 1, 1965
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