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A New Treatment of Meniere's Disease

A New Treatment of Meniere's Disease Abstract Vestibular Depression by a Droperidol-Fentanyl Combination JANSSEN has recently developed several analgesic and hypnotic drugs.1 Two of these have been used in combination to produce an anesthetic state.2-6 They are droperidol and fentanyl citrate (Innovar), with a droperidolfentanyl ratio of 50:1. One cubic centimeter of the mixture contains 0.05 mg fentanyl and 2.5 mg droperidol.Fentanyl is a highly potent analgesic with a rapid onset and short duration of action. It possesses a weak emetic action and produces mild vagal stimulation. Droperidol belongs to an entirely new class of compounds known as butyrophenones. It produces sedation and a state of psychic detachment but leaves the patient able to cooperate intelligently on demand. Its onset is from five to ten minutes and lasts more than six hours. Droperidol possesses potent antiemetic properties and seems to protect against some ventricular arrhythmias. In combination these drugs produce an anesthetic condition that References 1. Janssen Research Products Information Service, Teratological Data of Innovar, Research Laboratorium Dr. C. Janssen. 2. Decastro, J., and Mundeleer, P.: Anesthesia sans barbiturique: la neuroleptanalgesia , Anesth Analg (Paris) 16:1022-1056, 1959. 3. Holderness, M.C.; Chase, P.E.; and Dripps, R.D.: A Narcotic Analgesic and a Butyrophenone With Nitrous Oxide for General Anesthesia , Anesthesiology 24:336-340, 1963.Crossref 4. Corssen, G.; Domino, E.F.; and Sweet, R.B.: Neurolept-Analgesia and Anesthesia: Pharmacologic and Clinical Considerations , Anesth Analg (Cleveland) 43:744, 1964. 5. Dobkin, A.B.; Israel, J.S.; and Byles, P.H.: Innovar-N2O Anaesthesia in Normal Men: Effect on Respiration, Circulatory Dynamics, Liver Function, Metabolic Functions, Acid-Base Balance, and Psychic Responses , Can Anaesth Soc J 11:41, 1964.Crossref 6. Nilsson, E.: Experience With Neuroleptanalgesia , Anaesthesist 11:17, 1962. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1965.00760010496007
Publisher site
See Article on Publisher Site

Abstract

Abstract Vestibular Depression by a Droperidol-Fentanyl Combination JANSSEN has recently developed several analgesic and hypnotic drugs.1 Two of these have been used in combination to produce an anesthetic state.2-6 They are droperidol and fentanyl citrate (Innovar), with a droperidolfentanyl ratio of 50:1. One cubic centimeter of the mixture contains 0.05 mg fentanyl and 2.5 mg droperidol.Fentanyl is a highly potent analgesic with a rapid onset and short duration of action. It possesses a weak emetic action and produces mild vagal stimulation. Droperidol belongs to an entirely new class of compounds known as butyrophenones. It produces sedation and a state of psychic detachment but leaves the patient able to cooperate intelligently on demand. Its onset is from five to ten minutes and lasts more than six hours. Droperidol possesses potent antiemetic properties and seems to protect against some ventricular arrhythmias. In combination these drugs produce an anesthetic condition that References 1. Janssen Research Products Information Service, Teratological Data of Innovar, Research Laboratorium Dr. C. Janssen. 2. Decastro, J., and Mundeleer, P.: Anesthesia sans barbiturique: la neuroleptanalgesia , Anesth Analg (Paris) 16:1022-1056, 1959. 3. Holderness, M.C.; Chase, P.E.; and Dripps, R.D.: A Narcotic Analgesic and a Butyrophenone With Nitrous Oxide for General Anesthesia , Anesthesiology 24:336-340, 1963.Crossref 4. Corssen, G.; Domino, E.F.; and Sweet, R.B.: Neurolept-Analgesia and Anesthesia: Pharmacologic and Clinical Considerations , Anesth Analg (Cleveland) 43:744, 1964. 5. Dobkin, A.B.; Israel, J.S.; and Byles, P.H.: Innovar-N2O Anaesthesia in Normal Men: Effect on Respiration, Circulatory Dynamics, Liver Function, Metabolic Functions, Acid-Base Balance, and Psychic Responses , Can Anaesth Soc J 11:41, 1964.Crossref 6. Nilsson, E.: Experience With Neuroleptanalgesia , Anaesthesist 11:17, 1962.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Nov 1, 1965

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