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Cupulometry as an Investigative Tool

Cupulometry as an Investigative Tool Abstract THE OBJECT of this study is to investigate the use of cupulometry in the clinical evaluation of drugs affecting the labyrinthine function. Specifically, this report concerns a doubleblind study of the effects of the drug cinnarizine upon the reaction to rotational stimuli. Cinnarizine is an antihistamine preparation of the piperazine group, structurally related to meclizine. Several investigators, among them Barrett and Zolov,1 Zolov,2 and Nelson and Stoesser,3 have studied the effects of this drug in various allergic conditions and conclude that it is an effective antihistaminic. Trumbull and co-workers4 in 1960 demonstrated that cinnarizine was able to prevent sea-sickness in a significant number of cases. More recently, Jongkees and Philipszoon5-8 investigated the effects of cinnarizine upon the labyrinthine function of experimental animals, patients with vertigo, and ten normal volunteers. It is upon this latter work that the present investigation is based. Philipszoon tested the reaction References 1. Barrett, R. J., Jr., and Zolov, B.: Clinical Evaluation of Cinnarizine (Mitronal) in Various Allergic Disorders , J Maine Med Assoc 51:454, 1960. 2. Zolov, B.: Clinical Evaluation of Cinnarizine in Various Allergic Disorders , Ann Allergy 19:1290, 1961. 3. Nelson, L. S., and Stoesser, A. V.: Clinical Trial of Mitronal in 161 Patients , Ann Allergy 20:107, 1962. 4. Trumbull, R., et al: Effect of Certain Drugs on Incidence of Seasickness , Clin Pharmacol Ther 1:280, 1960. 5. Philipszoon, A. J.: Effect of Some Drugs Upon Labyrinth, Thesis, Amsterdam, 1959. 6. Jongkees, L. B. W.: Influence of Some Drugs Upon Function of Labyrinth , Acta Otolaryng 53:281-285, 1961.Crossref 7. Philipszoon, A. J.: De invloed van cinnarizine op duizeligheid: Een elektronystagmografisch onderzoek bij 55 patienten , Ned T Geneesk 105:657, 1961. 8. Philipszoon, A. J.: Influence of Cinnarizine on Labyrinth and on Vertigo , Clin Pharmacol Ther 3:184-190, 1962. 9. van Egmond, A. A. J.; Groen, J. J.; and Jongkees, L. B. W.: Turning Test With Small Regulable Stimuli: Cupulometry , J Laryng 62:63-69, 1948.Crossref 10. Hamersma, H.: Caloric Test, Thesis, Amsterdam, 1957. 11. de Boer, E.: "Appendix," in Jongkees, L. B. W.; Maas, J. P. M.; and Philipszoon, A. J.: Clinical Nystagmography , Pract Otorhinolaryng 24:65, 1962. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Cupulometry as an Investigative Tool

DALY, JOHN F.; COHEN, NOEL L.
Archives of Otolaryngology , Volume 81 (4) – Apr 1, 1965
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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1965.00750050351005
Publisher site
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Abstract

Abstract THE OBJECT of this study is to investigate the use of cupulometry in the clinical evaluation of drugs affecting the labyrinthine function. Specifically, this report concerns a doubleblind study of the effects of the drug cinnarizine upon the reaction to rotational stimuli. Cinnarizine is an antihistamine preparation of the piperazine group, structurally related to meclizine. Several investigators, among them Barrett and Zolov,1 Zolov,2 and Nelson and Stoesser,3 have studied the effects of this drug in various allergic conditions and conclude that it is an effective antihistaminic. Trumbull and co-workers4 in 1960 demonstrated that cinnarizine was able to prevent sea-sickness in a significant number of cases. More recently, Jongkees and Philipszoon5-8 investigated the effects of cinnarizine upon the labyrinthine function of experimental animals, patients with vertigo, and ten normal volunteers. It is upon this latter work that the present investigation is based. Philipszoon tested the reaction References 1. Barrett, R. J., Jr., and Zolov, B.: Clinical Evaluation of Cinnarizine (Mitronal) in Various Allergic Disorders , J Maine Med Assoc 51:454, 1960. 2. Zolov, B.: Clinical Evaluation of Cinnarizine in Various Allergic Disorders , Ann Allergy 19:1290, 1961. 3. Nelson, L. S., and Stoesser, A. V.: Clinical Trial of Mitronal in 161 Patients , Ann Allergy 20:107, 1962. 4. Trumbull, R., et al: Effect of Certain Drugs on Incidence of Seasickness , Clin Pharmacol Ther 1:280, 1960. 5. Philipszoon, A. J.: Effect of Some Drugs Upon Labyrinth, Thesis, Amsterdam, 1959. 6. Jongkees, L. B. W.: Influence of Some Drugs Upon Function of Labyrinth , Acta Otolaryng 53:281-285, 1961.Crossref 7. Philipszoon, A. J.: De invloed van cinnarizine op duizeligheid: Een elektronystagmografisch onderzoek bij 55 patienten , Ned T Geneesk 105:657, 1961. 8. Philipszoon, A. J.: Influence of Cinnarizine on Labyrinth and on Vertigo , Clin Pharmacol Ther 3:184-190, 1962. 9. van Egmond, A. A. J.; Groen, J. J.; and Jongkees, L. B. W.: Turning Test With Small Regulable Stimuli: Cupulometry , J Laryng 62:63-69, 1948.Crossref 10. Hamersma, H.: Caloric Test, Thesis, Amsterdam, 1957. 11. de Boer, E.: "Appendix," in Jongkees, L. B. W.; Maas, J. P. M.; and Philipszoon, A. J.: Clinical Nystagmography , Pract Otorhinolaryng 24:65, 1962.

Journal

Archives of Otolaryngology – American Medical Association

Published: Apr 1, 1965

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