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Observations on the Use of Edathamil Disodium in Human Ears

Observations on the Use of Edathamil Disodium in Human Ears Abstract A chelating agent is an organic compound capable of forming a stable complex with a multivalent positive ion such as calcium. In this process, coordinate bonding occurs in some of the atoms forming the ring, as a result of which the calcium becomes such an integral part of the complex that it loses its ionic properties and cannot be precipitated by commonly used precipitating agents. This ability to bind calcium enables certain chelating agents to be used in the body to decalcify bone,1 to remove calcium deposits in the cornea,2 and to remove urinary calculi (experimentally).3 Many new uses are now being reported. The agent is presently administered intravenously, and, if properly given, can produce good results without causing hypocalcemia or any other notable adverse effects in the body. In exploring the use of a chelating agent in otosclerosis, at least four objectives become theoretically possible: To make surgical References 1. Spencer, H.; Vankinscott, V.; Lewin, I., and Laszlo, D.: Removal of Calcium in Man by Ethylenediamine Tetraacetic Acid: A Metabolic Study , J. Clin. Invest. 31:1023-1027 ( (Dec.) ) 1952.Crossref 2. Grant, W. M.: New Treatment for Calcific Corneal Opacities , A. M. A. Arch. Ophth. 48:681-685 ( (Dec.) ) 1952.Crossref 3. Gehres, R. F., and Raymond, S.: A New Chemical Approach to the Dissolution of Urinary Calculi , J. Urol. 65:474-483 ( (March) ) 1951. 4. Sataloff, J.: Chelation of Stapes Footplate , A. M. A. Arch. Otolaryng. 69:1-6 ( (Jan.) ) 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

Observations on the Use of Edathamil Disodium in Human Ears

SATALOFF, JOSEPH
A.M.A. Archives of Otolaryngology , Volume 69 (4) – Apr 1, 1959
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1959.00730030445010
Publisher site
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Abstract

Abstract A chelating agent is an organic compound capable of forming a stable complex with a multivalent positive ion such as calcium. In this process, coordinate bonding occurs in some of the atoms forming the ring, as a result of which the calcium becomes such an integral part of the complex that it loses its ionic properties and cannot be precipitated by commonly used precipitating agents. This ability to bind calcium enables certain chelating agents to be used in the body to decalcify bone,1 to remove calcium deposits in the cornea,2 and to remove urinary calculi (experimentally).3 Many new uses are now being reported. The agent is presently administered intravenously, and, if properly given, can produce good results without causing hypocalcemia or any other notable adverse effects in the body. In exploring the use of a chelating agent in otosclerosis, at least four objectives become theoretically possible: To make surgical References 1. Spencer, H.; Vankinscott, V.; Lewin, I., and Laszlo, D.: Removal of Calcium in Man by Ethylenediamine Tetraacetic Acid: A Metabolic Study , J. Clin. Invest. 31:1023-1027 ( (Dec.) ) 1952.Crossref 2. Grant, W. M.: New Treatment for Calcific Corneal Opacities , A. M. A. Arch. Ophth. 48:681-685 ( (Dec.) ) 1952.Crossref 3. Gehres, R. F., and Raymond, S.: A New Chemical Approach to the Dissolution of Urinary Calculi , J. Urol. 65:474-483 ( (March) ) 1951. 4. Sataloff, J.: Chelation of Stapes Footplate , A. M. A. Arch. Otolaryng. 69:1-6 ( (Jan.) ) 1959.Crossref

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: Apr 1, 1959

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