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Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig)

Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig) Abstract Autolysis is initiated immediately after death. Since Nager and Yoshii1 called attention to postmortem changes and the fact that they appear in the inner ear before they are observed in other structures, intravital fixation has been adopted as the best procedure for histological preparations in experimental animals. Nevertheless, confusion about what is meant by normal inner ear still exists. In addition to artifacts, agonal and postmortem changes, position, size, and shape of cells and membranes in living and fixed tissue have been the center of many debates. The investigation to be described here was primarily an attempt to obtain more knowledge about the sequence of autolytic changes of the inner ear in the guinea pig, as seen under light microscopy. During the histologic study of the guinea pig temporal bones, three additional points become apparent: first, to report the pathologic changes which may be found in young, normal guinea References 1. Nager, F., und Yoshii, U.: Zur Zenntnis der cadaverösen Veränderungen des inneren Ohres , Ztschr. Ohrenh. 60:93-106, 1910. 2. Schuknecht, H. F.: Techniques for Study of Cochlear Function and Pathology in Experimental Animals , A. M. A. Arch. Otolaryng. 58:377-397, 1953.Crossref 3. Kimura, R., and Perlman, H.: Extensive Venous Obstruction of the Labyrinth: A. Cochlear Changes , Ann. Otol. Rhin. & Laryng. 65:332-351, 1956. 4. Tanaka, K.: Experimental Study on the Correlation Between Tubar Stenosis and Occupational Deafness , Acta med. Okayama 8:319-328, 1953. 5. Saxén, A.: On Cysts and Infarcts Occurring in Stria Vascularis , Acta oto-laryng. , (Supp. 67) , pp. 101-106, 1948. 6. Werner, CI. F.: Das Labyrinth , Leipzig, Georg Thieme Verlag, 1940. 7. Baker, J. R.: Cytological Technique , London, Methuen & Co., Ltd., 1955. 8. Falbe-Hansen, J.: Clinical and Experimental Histological Studies on Effects of Salicylate and Quinine on the Ear , Acta oto-laryng. , (Supp. 44) , pp. 1-21, 1941. 9. Mygind, S. H.; Andersen, H. C., and Arnvig, J.: Experimental Histological Studies on the Labyrinth: V. Comparison Between the Results of Fixation with Wittmaack's Fluid and with "Susa," Acta oto-laryng. 33:273-280, 1945. 10. Mygind, S. H.: Experimental Histological Studies on the Labyrinth: III. The Endolymphatic Compression (Wittmaack's Hypotonic Degeneration) , Acta oto-laryng. 33:86-116, 1945. 11. Fernández, C., and Alzate, R.: Modifications of Cochlear Responses by Oxygen Deprivation, in preparation. 12. Wittmaack, K.: cited by Mygind.10 13. Wittmaack, K., and Laurowitsch, Z.: Über artifizielle postmortale und agonale Beeinflussung der histologischen Befunde im membranösen Labyrinthe , Ztschr. Ohrenh. 65:157-189, 1912. 14. Mygind. S. H.: Experimental Histological Studies on the Labyrinth: II. Agonal and Post-Mortem Changes , Acta Otolaryng. 33:79-85, 1945. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig)

A.M.A. Archives of Otolaryngology , Volume 68 (4) – Oct 1, 1958

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1958.00730020480009
Publisher site
See Article on Publisher Site

Abstract

Abstract Autolysis is initiated immediately after death. Since Nager and Yoshii1 called attention to postmortem changes and the fact that they appear in the inner ear before they are observed in other structures, intravital fixation has been adopted as the best procedure for histological preparations in experimental animals. Nevertheless, confusion about what is meant by normal inner ear still exists. In addition to artifacts, agonal and postmortem changes, position, size, and shape of cells and membranes in living and fixed tissue have been the center of many debates. The investigation to be described here was primarily an attempt to obtain more knowledge about the sequence of autolytic changes of the inner ear in the guinea pig, as seen under light microscopy. During the histologic study of the guinea pig temporal bones, three additional points become apparent: first, to report the pathologic changes which may be found in young, normal guinea References 1. Nager, F., und Yoshii, U.: Zur Zenntnis der cadaverösen Veränderungen des inneren Ohres , Ztschr. Ohrenh. 60:93-106, 1910. 2. Schuknecht, H. F.: Techniques for Study of Cochlear Function and Pathology in Experimental Animals , A. M. A. Arch. Otolaryng. 58:377-397, 1953.Crossref 3. Kimura, R., and Perlman, H.: Extensive Venous Obstruction of the Labyrinth: A. Cochlear Changes , Ann. Otol. Rhin. & Laryng. 65:332-351, 1956. 4. Tanaka, K.: Experimental Study on the Correlation Between Tubar Stenosis and Occupational Deafness , Acta med. Okayama 8:319-328, 1953. 5. Saxén, A.: On Cysts and Infarcts Occurring in Stria Vascularis , Acta oto-laryng. , (Supp. 67) , pp. 101-106, 1948. 6. Werner, CI. F.: Das Labyrinth , Leipzig, Georg Thieme Verlag, 1940. 7. Baker, J. R.: Cytological Technique , London, Methuen & Co., Ltd., 1955. 8. Falbe-Hansen, J.: Clinical and Experimental Histological Studies on Effects of Salicylate and Quinine on the Ear , Acta oto-laryng. , (Supp. 44) , pp. 1-21, 1941. 9. Mygind, S. H.; Andersen, H. C., and Arnvig, J.: Experimental Histological Studies on the Labyrinth: V. Comparison Between the Results of Fixation with Wittmaack's Fluid and with "Susa," Acta oto-laryng. 33:273-280, 1945. 10. Mygind, S. H.: Experimental Histological Studies on the Labyrinth: III. The Endolymphatic Compression (Wittmaack's Hypotonic Degeneration) , Acta oto-laryng. 33:86-116, 1945. 11. Fernández, C., and Alzate, R.: Modifications of Cochlear Responses by Oxygen Deprivation, in preparation. 12. Wittmaack, K.: cited by Mygind.10 13. Wittmaack, K., and Laurowitsch, Z.: Über artifizielle postmortale und agonale Beeinflussung der histologischen Befunde im membranösen Labyrinthe , Ztschr. Ohrenh. 65:157-189, 1912. 14. Mygind. S. H.: Experimental Histological Studies on the Labyrinth: II. Agonal and Post-Mortem Changes , Acta Otolaryng. 33:79-85, 1945.

Journal

A.M.A. Archives of OtolaryngologyAmerican Medical Association

Published: Oct 1, 1958

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