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A. White, T. Dougherty (1945)
EFFECT OF PROLONGED STIMULATION OF THE ADRENAL CORTEX AND OF ADRENALECTOMY ON THE NUMBERS OF CIRCULATING ERYTHROCYTES AND LYMPHYOCYTES1Endocrinology, 36
T. Dougherty, A. White (1946)
Increased plasma cell production following adrenal cortical stimulation.The Anatomical record, 94
Good Ra (1955)
Studies on agammaglobulinemia. II. Failure of plasma cell formation in the bone marrow and lymph nodes of patients with agammaglobulinemia.Journal of Laboratory and Clinical Medicine, 46
T. Dougherty, Abraham White (1946)
Pituitary-adrenal cortical control of lymphocyte structure and function as revealed by experimental X-radiation.Endocrinology, 39 6
T. Dougherty, A. White (1945)
Functional alterations in lymphoid tissue induced by adrenal cortical secretionAmerican Journal of Anatomy, 77
Abstract A type of hypogammaglobulinemia is reported in which certain adrenal cortical hormones enhance the release of antibody. Analysis of our 48 cases showed two main types. First, a predominant type found in the hypolymphatic type of person described by Good. Second, a type found in a small number of cases, about 10% of persons with hyperplasia of the lymphoid tissue. The following study attempts to demonstrate that, despite the fact that adrenal cortical hormones are responsible for the inhibition of lymphocyte formation, they may raise the blood level of globulins by clinically significant amounts. In reviewing the series of hypogammaglobulin cases, we found one report of a mother and a newborn baby, both with marked hypogammaglobulinemia. The child developed pneumonia within the first day of life. The infection did not respond to antibiotics but, on being given gamma globulin, the child recovered promptly. In seeking an explanation of why only References 1. Good, R. A.; J. Lab. & Clin. Med. 46:167, 1955. 2. Dougherty, T. F., and White, A.: Proc. Soc. Exper. Biol. & Med. 53:132, 1943. 3. Dougherty, T. F., and White, A.: Endocrinology 35:1, 1944. 4. Dougherty, T. F., and White, A.: Endocrinology 36:16, 1945. 5. Dougherty, T. F., and White, A.: Am. J. Anat. 77:81, 1945. 6. Dougherty, T. F., and White, A.: Anat. Rec. 94:457, 1946. 7. Dougherty, T. F., and White, A.: Endocrinology 39:370, 1946. 8. Hammond, C. W., and Novak, M.: Proc. Soc. Exper. Biol. & Med. 74:155, 1950.
A.M.A. Archives of Otolaryngology – American Medical Association
Published: Sep 1, 1957
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